Heterogeneity in respiratory syncytial virus (RSV) disease severity likely is due to a combination of host and viral factors.Infection with RSV subgroup A is thought to produce more severe disease than RSV-B.Higher RS...Heterogeneity in respiratory syncytial virus (RSV) disease severity likely is due to a combination of host and viral factors.Infection with RSV subgroup A is thought to produce more severe disease than RSV-B.Higher RSV loads correlate with greater disease severity in hospitalized infants.Whether subgroup-specific variations in disease severity result from differences in RSV load has not been studied.A total of 102 RSV-hospitalized infants < 2 y of age were studied.Nasal washes were collected in a standardized manner and were cultured in < 3 h in parallel with an RSV quantitative standard in a HEp-2 plaque assay.RSV-A (72%) was more frequent than RSV-B.Disease severity risk factors were similar between subgroups.RSV load swere similar between A and B subgroups (4.77 versus 4.68 log PFU/mL).Measures of disease severity were also similar between subgroups.展开更多
文摘Heterogeneity in respiratory syncytial virus (RSV) disease severity likely is due to a combination of host and viral factors.Infection with RSV subgroup A is thought to produce more severe disease than RSV-B.Higher RSV loads correlate with greater disease severity in hospitalized infants.Whether subgroup-specific variations in disease severity result from differences in RSV load has not been studied.A total of 102 RSV-hospitalized infants < 2 y of age were studied.Nasal washes were collected in a standardized manner and were cultured in < 3 h in parallel with an RSV quantitative standard in a HEp-2 plaque assay.RSV-A (72%) was more frequent than RSV-B.Disease severity risk factors were similar between subgroups.RSV load swere similar between A and B subgroups (4.77 versus 4.68 log PFU/mL).Measures of disease severity were also similar between subgroups.
