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大肠埃希菌O157:H7相关的溶血性尿毒综合征患儿中降钙素原的作用
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作者 decaluwe h. harrison L.M. +2 位作者 Mariscalco M.M. F. Proulx 刘凯 《世界核心医学期刊文摘(儿科学分册)》 2006年第12期52-53,共2页
Shiga toxin producing Escherichia coli (STEC) are noninvasive enteric pathogens that may cause hemorrhagic colitis (HC) and diarrhea-associated hemolytic uremic syndrome (D+HUS). We hypothesized that development of D+... Shiga toxin producing Escherichia coli (STEC) are noninvasive enteric pathogens that may cause hemorrhagic colitis (HC) and diarrhea-associated hemolytic uremic syndrome (D+HUS). We hypothesized that development of D+HUS is associated with increased serum procalcitonin (PCT) levels. PCT was measured by an immunoluminometric assay in 113 patients. Concentrations of PCT were different in normal controls,disease control groups (rotavirus enteritis,HC due to non-STEC pathogens,chronic renal failure),and children with uncomplicated O157:H7HC or D+HUS. Children with D+HUS showed higher PCT levels than those with uncomplicated O157:H7 HC,and increased concentrations were noted in cases requiring peritoneal dialysis. Severely increased concentrations were observed in children with D+HUS on d 5 or 6 after the onset of enteritis,whereas serial measurements in those with uncomplicated O157:H7 HC remained within the normal range throughout the first week of illness. PCT was correlated with serum concentrations of lipopolysaccharide (LPS)-binding protein and serum levels of alanine aminotransferase. Using two separate sets of real-time PCR primers,we were unable to detect elevated PCT mRNA transcripts in nonadherent undifferentiated (monocytic) or differentiated (macrophage-like) THP-1 cells stimulated with purified Shiga toxin-1 and/or LPS. Our data show that serum levels of PCT are associated with the severity of illness in children with D+HUS. Further studies are needed to determine the role of PCT in the pathogenesis of thrombotic microangiopathy associated to childhood D+HUS. 展开更多
关键词 O157:H7 大肠埃希菌 降钙素原 轮状病毒肠炎 出血性结肠炎 免疫发光法 志贺毒素 慢性肾功能衰
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