OMARIA which is used to treat malaria in Odisa province, India, was investigated in Africa. The in-vitro anti-malarial activity of OMARIA was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloro...OMARIA which is used to treat malaria in Odisa province, India, was investigated in Africa. The in-vitro anti-malarial activity of OMARIA was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates from Gabon, using the DELI method. Host cell toxicity was analysed with the MTT test. Interesting activity was observed. Inhibition concentrations (IC50) were 20.6 ± 5.2 μg/ml and 14.1 ± 4.3μg/ml respectively on FCB and 3D7 strains. On clinical isolates, the mean of IC50 was 10.65 ± 4.8μg/ml. OMARIA is highly potent against all field isolates tested by us (Gabon includes Pfmdr1 N86). Lethal dose on Vero cells being 165 ± 10.7μg/ml indicate a selective index of 13 for FCB, i.e., non-toxic. Data substantiates scientific rationale for use of OMARIA. This information and such understanding can be used in searching African phyto parables (for use in Africa with similar results as in India) and in new drug design. With Indian assistance, Punica granatum can also be cultivated in Central Africa, and OMARIA can be made, with an aim to Fight Malaria at Home.展开更多
Based on mono station use for >12 continuous years (since 1998) in drug resistant core endemic region, India, anti-inflammatory effect on WBC is demonstrated using a simple;economic monocular microscope that can be...Based on mono station use for >12 continuous years (since 1998) in drug resistant core endemic region, India, anti-inflammatory effect on WBC is demonstrated using a simple;economic monocular microscope that can be used out in the open—using day light/lamp. Is infinitely helpful for rural clinicians and the administrations, in developing nations. Although indispensable, a field microscope has become expensive;is in short supply;there is a crying need in the rural and the remote.展开更多
India is an ancient land having high seasonal rain fall (4 months rain & 8 months dry), has paddy cultivation. Becauses silt-sand separation;buoyant sand gets carried;silt agglutinates. Rill fluid dissolves agglut...India is an ancient land having high seasonal rain fall (4 months rain & 8 months dry), has paddy cultivation. Becauses silt-sand separation;buoyant sand gets carried;silt agglutinates. Rill fluid dissolves agglutinated soil;vectors as silt → degradation. Indian farmer has unique agricultural field conservation;soil cum fertility maintenance/regeneration heritage. Also use the stubble and cow dung (cellulose) as binder cum multi purpose in-field uses. economic;ecologically safe;and not discussed earlier. Good tool for altruistic administrations.展开更多
文摘OMARIA which is used to treat malaria in Odisa province, India, was investigated in Africa. The in-vitro anti-malarial activity of OMARIA was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates from Gabon, using the DELI method. Host cell toxicity was analysed with the MTT test. Interesting activity was observed. Inhibition concentrations (IC50) were 20.6 ± 5.2 μg/ml and 14.1 ± 4.3μg/ml respectively on FCB and 3D7 strains. On clinical isolates, the mean of IC50 was 10.65 ± 4.8μg/ml. OMARIA is highly potent against all field isolates tested by us (Gabon includes Pfmdr1 N86). Lethal dose on Vero cells being 165 ± 10.7μg/ml indicate a selective index of 13 for FCB, i.e., non-toxic. Data substantiates scientific rationale for use of OMARIA. This information and such understanding can be used in searching African phyto parables (for use in Africa with similar results as in India) and in new drug design. With Indian assistance, Punica granatum can also be cultivated in Central Africa, and OMARIA can be made, with an aim to Fight Malaria at Home.
文摘Based on mono station use for >12 continuous years (since 1998) in drug resistant core endemic region, India, anti-inflammatory effect on WBC is demonstrated using a simple;economic monocular microscope that can be used out in the open—using day light/lamp. Is infinitely helpful for rural clinicians and the administrations, in developing nations. Although indispensable, a field microscope has become expensive;is in short supply;there is a crying need in the rural and the remote.
文摘India is an ancient land having high seasonal rain fall (4 months rain & 8 months dry), has paddy cultivation. Becauses silt-sand separation;buoyant sand gets carried;silt agglutinates. Rill fluid dissolves agglutinated soil;vectors as silt → degradation. Indian farmer has unique agricultural field conservation;soil cum fertility maintenance/regeneration heritage. Also use the stubble and cow dung (cellulose) as binder cum multi purpose in-field uses. economic;ecologically safe;and not discussed earlier. Good tool for altruistic administrations.
