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Wnt5a在炎性疾病中具有双向调节性 被引量:1
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作者 陈旭 刘红玲 +2 位作者 李德红 王金穗 赵凤辉 《Chinese Medical Sciences Journal》 CAS CSCD 2022年第3期265-274,I0013,共11页
Wnt5a是一种分泌性的Wnt蛋白,在细胞通路及炎性疾病中扮演重要作用。WNT5A基因可编码形成Wnt5a长链蛋白和Wnt5a短链蛋白,这两种蛋白的形成取决于WNT5A基因启动子甲基化的部位,具有不同的功能。然而,WNT5A基因启动子甲基化的机制目前仍... Wnt5a是一种分泌性的Wnt蛋白,在细胞通路及炎性疾病中扮演重要作用。WNT5A基因可编码形成Wnt5a长链蛋白和Wnt5a短链蛋白,这两种蛋白的形成取决于WNT5A基因启动子甲基化的部位,具有不同的功能。然而,WNT5A基因启动子甲基化的机制目前仍然不清楚。在炎性疾病中,因为WNT5A基因甲基化的部位不同,Wnt5a具有抑制炎症和促进炎症的双面功能,这或许涉及Wnt5a蛋白不同的亚型。因此,Wnt5a蛋白的不同亚型或许是潜在的炎性疾病诊断标记,WNT5A基因甲基化的具体机制也需要深入研究。 展开更多
关键词 WNT5A 炎性疾病 启动子甲基化
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胃癌分子标志物环状RNA研究进展 被引量:6
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作者 鲁彦 李德红(综述) 杨伟林(审校) 《中国肿瘤临床》 CAS CSCD 北大核心 2022年第3期150-154,共5页
环状RNA(circular RNA,circRNA)是广泛存在于多物种细胞中结构稳定、高度保守、表达量丰富、可充当微小RNA海绵、具有剪切和转录调控、亲代基因修饰功能的内源性单链闭合circRNA。circRNA主要通过套索驱动的环化、内含子配对驱动的循环... 环状RNA(circular RNA,circRNA)是广泛存在于多物种细胞中结构稳定、高度保守、表达量丰富、可充当微小RNA海绵、具有剪切和转录调控、亲代基因修饰功能的内源性单链闭合circRNA。circRNA主要通过套索驱动的环化、内含子配对驱动的循环、内含子环化方式合成。在胃癌发生和进展过程中,不同种类的circRNA作用不一致。部分circRNA在胃癌组织中表达上调,通过微小RNA/p53/上皮细胞-间充质转化轴等机制促进胃癌细胞增殖、迁移;相反,部分circRNA在胃癌组织中表达下调,通过与miRNA间的海绵作用抑制胃癌细胞增殖和迁移。目前,已在人类唾液、胃液、血浆等成分中检测出胃癌相关的circRNA,提示circRNA具有作为胃癌诊断标志物的潜力。干预circRNA表达提高抗肿瘤药物敏感度,体外合成具有抑癌基因作用的circRNA,或下调具有癌基因作用的circRNA下游信号蛋白是胃癌治疗的有效手段。circRNA为胃癌的诊断和治疗提供了新的思路。 展开更多
关键词 环状RNA 胃癌 生物标志物 靶点
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Design and analysis of a novel hybrid cooling method of high-speed high-power permanent magnet assisted synchronous reluctance starter/generator in aviation applications
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作者 Hong GUO Xu HE +4 位作者 Jinquan XU Wei TIAN Xiaofeng DING Laicai JU dehong li 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第3期285-302,共18页
To improve the heat dissipation performance,this paper proposes a novel hybrid cooling method for high-speed high-power Permanent Magnet assisted Synchronous Reluctance Starter/Generator(PMa Syn R S/G)in aerospace app... To improve the heat dissipation performance,this paper proposes a novel hybrid cooling method for high-speed high-power Permanent Magnet assisted Synchronous Reluctance Starter/Generator(PMa Syn R S/G)in aerospace applications.The hybrid cooling structure with oil circulation in the housing,oil spray at winding ends and rotor end surface is firstly proposed for the PMa Syn R S/G.Then the accurate loss calculation of the PMa Syn R S/G is proposed,which includes air gap friction loss under oil spray cooling,copper loss,stator and rotor core loss,permanent magnet eddy current loss and bearing loss.The parameter sensitivity analysis of the hybrid cooling structure is proposed,while the equivalent thermal network model of the PMa Syn R S/G is established considering the uneven spraying at the winding ends.Finally,the effectiveness of the proposed hybrid cooling method is demonstrated on a 40 k W/24000 r/min PMa Syn R S/G experimental platform. 展开更多
关键词 Air gap friction loss Oil spray cooling Permanent magnet assisted synchronous reluctance starter/generator Thermal analysis Thermal network model
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Observation of biophoton emission from plants in the process of defense response 被引量:3
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作者 Da Xing Shici Tan +2 位作者 Yonghong Tang Yonghong He dehong li 《Chinese Science Bulletin》 SCIE EI CAS 1999年第23期2159-2162,共4页
Biophoton emission from germinating soybean under adverse circumstance has been observed by high sensitive imaging system based on ICCD detector. It is found that the intensity of biophoton emission from the injured p... Biophoton emission from germinating soybean under adverse circumstance has been observed by high sensitive imaging system based on ICCD detector. It is found that the intensity of biophoton emission from the injured position of the cotyledon is enhanced obviously compared with the intact position. In addition, a strong biophoton emission has been detected at the tip 展开更多
关键词 ultra-weak LUMINESCENCE WOUNDING BIOPHOTON emission DEFENSE response active oxygen.
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