THE observation of the formation of triplex DNA opened a possibility to control gene expression. Since then vast applications on biology and novel approaches to therapeutics have been accumulated considerably. Novel a...THE observation of the formation of triplex DNA opened a possibility to control gene expression. Since then vast applications on biology and novel approaches to therapeutics have been accumulated considerably. Novel approaches that have been developed in the past decades have the capability to supplement or to replace the classical drug paradigm of small molecules to the development of pharmaceuticals. The distinct field of oligonucleotide therapeutic can be possible when an additive oligonucleotide is targeted to a specified double helical DNA. The use of complementary DNA sequences to arrest translation of mRNAs also opens new possibilities for an artificial control of gene expression. The interest in the stability of the formation of a triplex DNA has been driven largely by the ability to synthesize oligonucleotides.展开更多
文摘THE observation of the formation of triplex DNA opened a possibility to control gene expression. Since then vast applications on biology and novel approaches to therapeutics have been accumulated considerably. Novel approaches that have been developed in the past decades have the capability to supplement or to replace the classical drug paradigm of small molecules to the development of pharmaceuticals. The distinct field of oligonucleotide therapeutic can be possible when an additive oligonucleotide is targeted to a specified double helical DNA. The use of complementary DNA sequences to arrest translation of mRNAs also opens new possibilities for an artificial control of gene expression. The interest in the stability of the formation of a triplex DNA has been driven largely by the ability to synthesize oligonucleotides.
