Chemotherapy has occupied the critical position in cancer therapy,especially towards the post-operative,advanced,recurrent,and metastatic tumors.Paclitaxel(PTX)-based formulations have been widely used in clinical pra...Chemotherapy has occupied the critical position in cancer therapy,especially towards the post-operative,advanced,recurrent,and metastatic tumors.Paclitaxel(PTX)-based formulations have been widely used in clinical practice,while the therapeutic effect is far from satisfied due to off-target toxicity and drug resistance.The caseless multi-components make the preparation technology complicated and aggravate the concerns with the excipients-associated toxicity.The self-assembled PTX nanoparticles possess a high drug content and could incorporate various functional molecules for enhancing the therapeutic index.In this work,we summarize the self-assembly strategy for diverse nanodrugs of PTX.Then,the advancement of nanodrugs for tumor therapy,especially emphasis on monochemotherapy,combinational therapy,and theranostics,have been outlined.Finally,the challenges and potential improvements have been briefly spotlighted.展开更多
Organic diradicaloids with unique open-shell structures and properties have been widely used in organic electronics and spintronics.However,their advantageous optical properties have been explored less in the biomedic...Organic diradicaloids with unique open-shell structures and properties have been widely used in organic electronics and spintronics.However,their advantageous optical properties have been explored less in the biomedical field.In this work,the photothermal conversion behaviors of a boron-containing organic diradicaloid(BOD)are reported.BOD can assemble with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol)to form rodlike nanoparticles(BOD NPs).These as-prepared BOD NPs exhibit high photothermal conversion capability and robust photothermal stability.Notably,they possess morphological superiority,which guarantees the effective photothermal therapy of tumors.This work thus demonstrates the promise of organic diradicaloids as efficient photothermal agents for biomedical applications.展开更多
基金the financial support from the National Natural Science Foundation of China(Nos.52203199 and 51973214)the Natural Science Foundation of Jilin Province(No.YDZJ202101ZYTS013)。
文摘Chemotherapy has occupied the critical position in cancer therapy,especially towards the post-operative,advanced,recurrent,and metastatic tumors.Paclitaxel(PTX)-based formulations have been widely used in clinical practice,while the therapeutic effect is far from satisfied due to off-target toxicity and drug resistance.The caseless multi-components make the preparation technology complicated and aggravate the concerns with the excipients-associated toxicity.The self-assembled PTX nanoparticles possess a high drug content and could incorporate various functional molecules for enhancing the therapeutic index.In this work,we summarize the self-assembly strategy for diverse nanodrugs of PTX.Then,the advancement of nanodrugs for tumor therapy,especially emphasis on monochemotherapy,combinational therapy,and theranostics,have been outlined.Finally,the challenges and potential improvements have been briefly spotlighted.
基金National Natural Science Foundation of China,Grant/Award Numbers:52003267,51973214,22175074Natural Science Foundation of Jilin Province,Grant/Award Numbers:YDZJ202101ZYTS027,20220101054JC。
文摘Organic diradicaloids with unique open-shell structures and properties have been widely used in organic electronics and spintronics.However,their advantageous optical properties have been explored less in the biomedical field.In this work,the photothermal conversion behaviors of a boron-containing organic diradicaloid(BOD)are reported.BOD can assemble with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol)to form rodlike nanoparticles(BOD NPs).These as-prepared BOD NPs exhibit high photothermal conversion capability and robust photothermal stability.Notably,they possess morphological superiority,which guarantees the effective photothermal therapy of tumors.This work thus demonstrates the promise of organic diradicaloids as efficient photothermal agents for biomedical applications.
