Gao is the major G protein in neurons,where it transduces signals from numerous G proteincoupled receptors(GPCRs)such as D2 dopamine,μ-opioid,M2 muscarinic,or α2-adrenergic receptors.In 2013,the first mutations in G...Gao is the major G protein in neurons,where it transduces signals from numerous G proteincoupled receptors(GPCRs)such as D2 dopamine,μ-opioid,M2 muscarinic,or α2-adrenergic receptors.In 2013,the first mutations in GNAO1,the gene encoding Gao,were described in pediatric patients with encephalopathies(Nakamura et al.,2013),suffering from movementdisorders,epileptic seizures。展开更多
基金supported by the grant number 21-15-00138 from the Russian Science Foundation to VLK and DNS。
文摘Gao is the major G protein in neurons,where it transduces signals from numerous G proteincoupled receptors(GPCRs)such as D2 dopamine,μ-opioid,M2 muscarinic,or α2-adrenergic receptors.In 2013,the first mutations in GNAO1,the gene encoding Gao,were described in pediatric patients with encephalopathies(Nakamura et al.,2013),suffering from movementdisorders,epileptic seizures。
