Aim: To evaluate the effects of hydroxyethyl starch (6% HES 200/0.5) on cardiac output in hypotensive neonates with low cardiac output and absence of myocardial dysfunction. Methods: In a prospective randomized blinde...Aim: To evaluate the effects of hydroxyethyl starch (6% HES 200/0.5) on cardiac output in hypotensive neonates with low cardiac output and absence of myocardial dysfunction. Methods: In a prospective randomized blinded trial, 21 hypotensive neonates (mean gestational age of 29 ± 3 wk) were randomly allocated to receive infusions of either 5% albumin (albumin group), isotonic saline (saline group) or hydroxyethyl starch (HES group). Infants had to show low cardiac output and an absence of myocardial dysfunction for inclusion in the study. Cardiac output was assessed by Doppler- derived mean aortic flow velocity. Results: Ten minutes after infusion,67% of all infants had more than a 10% increase in cardiac output. Increases in mean aortic flow velocity (m/s; median and range) were 0.05 (- 0.02, + 0.07), 0.03 (- 0.03, + 0.12) and 0.03 (- 0.04, + 0.11) for the albumin, saline and HES groups, respectively (p = 0.79). The percentage of blood pressure normalization (95% confi dence interval) was 86% (60- 100) in the albumin group, 57% (20- 94) in the saline group and 71% (37- 100) in the HES group (P = 0.50). Conclusion: This study did not provide evidence that hydroxyethyl starch is more efficient than isotonic saline or albumin.展开更多
Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical c ord blood of 197 neonates were measured to evaluate their value as markers of in fection. Sixteen of the neonates were infected. The sensi...Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical c ord blood of 197 neonates were measured to evaluate their value as markers of in fection. Sixteen of the neonates were infected. The sensitivity, specificity, an d negative and positive predictive values were respectively 87.5%, 98.7%, 87.5 %, and 98.7%for Pa and 50%, 97%, 67%, and 94%for CRP. Serum PCT in cord bl ood seems to be a useful and early marker of antenatal infection.展开更多
文摘Aim: To evaluate the effects of hydroxyethyl starch (6% HES 200/0.5) on cardiac output in hypotensive neonates with low cardiac output and absence of myocardial dysfunction. Methods: In a prospective randomized blinded trial, 21 hypotensive neonates (mean gestational age of 29 ± 3 wk) were randomly allocated to receive infusions of either 5% albumin (albumin group), isotonic saline (saline group) or hydroxyethyl starch (HES group). Infants had to show low cardiac output and an absence of myocardial dysfunction for inclusion in the study. Cardiac output was assessed by Doppler- derived mean aortic flow velocity. Results: Ten minutes after infusion,67% of all infants had more than a 10% increase in cardiac output. Increases in mean aortic flow velocity (m/s; median and range) were 0.05 (- 0.02, + 0.07), 0.03 (- 0.03, + 0.12) and 0.03 (- 0.04, + 0.11) for the albumin, saline and HES groups, respectively (p = 0.79). The percentage of blood pressure normalization (95% confi dence interval) was 86% (60- 100) in the albumin group, 57% (20- 94) in the saline group and 71% (37- 100) in the HES group (P = 0.50). Conclusion: This study did not provide evidence that hydroxyethyl starch is more efficient than isotonic saline or albumin.
文摘Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical c ord blood of 197 neonates were measured to evaluate their value as markers of in fection. Sixteen of the neonates were infected. The sensitivity, specificity, an d negative and positive predictive values were respectively 87.5%, 98.7%, 87.5 %, and 98.7%for Pa and 50%, 97%, 67%, and 94%for CRP. Serum PCT in cord bl ood seems to be a useful and early marker of antenatal infection.
