FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during development.FE65 belongs to the FE65 protein family.This family is comp...FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during development.FE65 belongs to the FE65 protein family.This family is comprised of three members,FE65,FE65 like-1(FE65L1),and FE65 like-2(FE65L2).展开更多
The protein kinase C(PKC)family:PKC family is a subgroup of the AGC serine-threonine kinases that consists of 10 distinct members in mammals(Spitaler and Cantrell,2004).They all contain a C-terminal catalytic domain t...The protein kinase C(PKC)family:PKC family is a subgroup of the AGC serine-threonine kinases that consists of 10 distinct members in mammals(Spitaler and Cantrell,2004).They all contain a C-terminal catalytic domain that is connected to the N-terminal regulatory domains.PKCs are subdivided into three classes according to their structures and activators.The classical/conventional PKC isoforms possess tandem C1 domains that bind to their well-known activators diacylglycerol and phorbol esters and also contain a C2 domain that mediates the binding of Ca^2+-sensitive anionic phospholipids.展开更多
文摘FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during development.FE65 belongs to the FE65 protein family.This family is comprised of three members,FE65,FE65 like-1(FE65L1),and FE65 like-2(FE65L2).
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文摘The protein kinase C(PKC)family:PKC family is a subgroup of the AGC serine-threonine kinases that consists of 10 distinct members in mammals(Spitaler and Cantrell,2004).They all contain a C-terminal catalytic domain that is connected to the N-terminal regulatory domains.PKCs are subdivided into three classes according to their structures and activators.The classical/conventional PKC isoforms possess tandem C1 domains that bind to their well-known activators diacylglycerol and phorbol esters and also contain a C2 domain that mediates the binding of Ca^2+-sensitive anionic phospholipids.
