Kinetics of glycerol production by fermentation with osmotolerant yeast Candida krusei was studied. Suppositions of cell negative effect on and glucose inhibition in specific growth rate and glycerol assumption for en...Kinetics of glycerol production by fermentation with osmotolerant yeast Candida krusei was studied. Suppositions of cell negative effect on and glucose inhibition in specific growth rate and glycerol assumption for energy maintenance were made. Based on the suppositions, a set of unstructured kinetic models including cell groWth, glucose consumption and glycerol accumulation rate was proposed. To avoid the significant decrease of produced glyccerol in the latter fermentation stage, the fermentation was suggested to be ended when the concentration ratio of glycerol to glucose is close to 7.展开更多
Optimal glucose feed strategy for glycerol fed-batch fermentation was investigated by Pontryagin’s maximum principle to maximize the final glycerol yield. The problem was solved by a nonsingular control approach by s...Optimal glucose feed strategy for glycerol fed-batch fermentation was investigated by Pontryagin’s maximum principle to maximize the final glycerol yield. The problem was solved by a nonsingular control approach by selecting the culture volume as the control variable, then the general optimal feed profile was numerically determined.展开更多
基金From National Ninth Five Years Project (NO. 96-03-03-03A).
文摘Kinetics of glycerol production by fermentation with osmotolerant yeast Candida krusei was studied. Suppositions of cell negative effect on and glucose inhibition in specific growth rate and glycerol assumption for energy maintenance were made. Based on the suppositions, a set of unstructured kinetic models including cell groWth, glucose consumption and glycerol accumulation rate was proposed. To avoid the significant decrease of produced glyccerol in the latter fermentation stage, the fermentation was suggested to be ended when the concentration ratio of glycerol to glucose is close to 7.
基金From National Ninth Five Years Project (NO. 96-03-03-03A).
文摘Optimal glucose feed strategy for glycerol fed-batch fermentation was investigated by Pontryagin’s maximum principle to maximize the final glycerol yield. The problem was solved by a nonsingular control approach by selecting the culture volume as the control variable, then the general optimal feed profile was numerically determined.
