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伴原发性人类疱疹病毒6型(HHV-6)感染的药敏综合征(法语)
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作者 Debarbieux S. deroo-berger m.-c. +2 位作者 Grande S. A.Claudy 潘敏 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第10期25-26,共2页
Introduction.Drug hypersensitivity syndrome is a severe life-threatening drug reaction.An association between this syndrome and HHV6 reactivation has been hypothesized.Casereport.A 45 year-old women was treated with s... Introduction.Drug hypersensitivity syndrome is a severe life-threatening drug reaction.An association between this syndrome and HHV6 reactivation has been hypothesized.Casereport.A 45 year-old women was treated with sulfasalazine for polyarthralgia.One month after beginning the treatment,she developed a drug hypersensitivity syndrome with severe acute hepatic failure.HHV6 serology and serum PCR revealed a primary HHV6 infection.Discussion.We report the second case of drug hypersensitivity syndrome associated with a primary HHV6 infection.An immunological disorder may explain such an association by increasing viral replication.Detection and titration of anti-HHV6 antibodies in each case of drug hypersensitivity syndrome should help to confirm this association and possibly modify treatment strategy. 展开更多
关键词 人类疱疹病毒 HHV-6 药物反应 急性肝衰竭 柳氮磺胺吡啶 血清学 病毒复制 关节痛 抗体滴度
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