The three-component reaction of o-aminobenzaldehydes with 5-hydroxyindole and electron-rich areneshas been achieved through HFIP-mediated cascade hydride transfer/dearomative cyclization/CDC-typeimidization at room te...The three-component reaction of o-aminobenzaldehydes with 5-hydroxyindole and electron-rich areneshas been achieved through HFIP-mediated cascade hydride transfer/dearomative cyclization/CDC-typeimidization at room temperature under air,providing a variety of 2-arylspiroindolenines carrying diversefunctional groups with moderate to good yields.The derivatizations of the products also were conductedto enhance the synthetic practicality of this protocol.展开更多
基金We are grateful to the NSFC(21978144 and 21776148)the Support Plan on Science and Technology for Youth Innovation of Universities in Shandong Province(2019KJM002)+2 种基金The financial support from the Talents of High Level Scientific Research Foundation(6651118009,6631115015,and 6631110309)the Postgraduate Innovation Program(QNYCX20016)the Central Laboratory of Qingdao Agricultural University for NMR determination is also gratefully acknowledged.
文摘The three-component reaction of o-aminobenzaldehydes with 5-hydroxyindole and electron-rich areneshas been achieved through HFIP-mediated cascade hydride transfer/dearomative cyclization/CDC-typeimidization at room temperature under air,providing a variety of 2-arylspiroindolenines carrying diversefunctional groups with moderate to good yields.The derivatizations of the products also were conductedto enhance the synthetic practicality of this protocol.
