Aim:Topical rapamycin for angiofibromas has been reported to be a new promising treatment.This study aims to report the outcome in clinical practice.Methods:A retrospective clinical follow-up on twenty-three patients ...Aim:Topical rapamycin for angiofibromas has been reported to be a new promising treatment.This study aims to report the outcome in clinical practice.Methods:A retrospective clinical follow-up on twenty-three patients who had been prescribed an oral solution of 0.1%rapamycin,to be applied on facial lesions once a day.Results:Seventeen of 23 patients continued the treatment.Papules and nodules were improved in 8 patients(47%)and erythema in 12(70%).Side effects,such as stinging and redness were reported in 35%of patients.Blood samples were taken from 5 patients and no rapamycin could be detected.All patients who paused the treatment relapsed.Conclusion:Topical rapamycin has a positive effect on angiofibromas with improvement in both erythema and papules even if only applied every second to third day,but continuous treatment is needed.展开更多
文摘Aim:Topical rapamycin for angiofibromas has been reported to be a new promising treatment.This study aims to report the outcome in clinical practice.Methods:A retrospective clinical follow-up on twenty-three patients who had been prescribed an oral solution of 0.1%rapamycin,to be applied on facial lesions once a day.Results:Seventeen of 23 patients continued the treatment.Papules and nodules were improved in 8 patients(47%)and erythema in 12(70%).Side effects,such as stinging and redness were reported in 35%of patients.Blood samples were taken from 5 patients and no rapamycin could be detected.All patients who paused the treatment relapsed.Conclusion:Topical rapamycin has a positive effect on angiofibromas with improvement in both erythema and papules even if only applied every second to third day,but continuous treatment is needed.
