Purpose: To investigate macular morphology by spectral domain optical coherence tomography (SDOCT) in children with history of the retinopathy of prematurity (ROP). Materials and methods: In this cross-sectional study...Purpose: To investigate macular morphology by spectral domain optical coherence tomography (SDOCT) in children with history of the retinopathy of prematurity (ROP). Materials and methods: In this cross-sectional study we included 35 eyes of 18 patients, aged 4 to 8 years, with history of ROP. Twenty-one eyes had received treatment for type 1 pre-threshold ROP. The others showed spontaneous regression of the disease. A 7 × 7-mm retinal area was sampled using a 3-dimensional scanning protocol with high-resolution spectral domain optical coherence tomography (SOCT Copernicus REVO). The central foveal thickness, mean macular thickness, macular volume and foveal depression were measured. The macular anatomy and the foveal contour were examined. Results: The mean birth weight was 1338.29 ± 324.05 grams. Mean gestational age at birth was 29.37 ± 2.07 weeks. Twenty-one eyes were treated with laser or cryotherapy. All of them showed regression of the disease. The mean best corrected visual acuity was 20/28. The average central foveal thickness was 262.26 ± 37.39, with 68.57% of preterm > 240 μm and 22.86% > 220 μm. In all eyes, the foveal contour is abnormal. A foveal depression was absent in 25 eyes (71%). Conclusion: In the majority of children with a history of ROP, we found changes in macular morphology, including retention of inner retinal layers and absent foveal depression. In our study foveal hypoplasia was associated with good functional outcome.展开更多
Optical coherence tomography-angiography (OCT-A) is a relatively new non-invasive imaging technique which provides three-dimensional visualization of the retinal and choroidal microvasculature. Recently, OCT-A is wide...Optical coherence tomography-angiography (OCT-A) is a relatively new non-invasive imaging technique which provides three-dimensional visualization of the retinal and choroidal microvasculature. Recently, OCT-A is widely used in the diagnosis of age-related macular degeneration (AMD). Purpose: To compare 3 quantitative indexes of foveal avascular zone (FAZ)—area (A), perimeter (Pm), and circularity (C) in patients with early and intermediate nonexudative AMD and healthy subjects using OCT-A. Methods: Eighty-nine patients with nonexudative AMD (n = 89 eyes) were enrolled in the study. They were compared with sex- and age-matched control group of 66 healthy subjects (n = 66 eyes). The patients with nonexudative AMD were divided into 2 subgroups—early AMD (n = 42 eyes) and intermediate AMD (n = 47 eyes). All participants underwent OCT-A (3 × 3 mm scans, Cirrus HD-OCT, Angioplex, Carl Zeiss Meditec, Dublin, CA). Results: There was no statistically significant difference in all 3 assessed indexes between the early AMD subgroup and the control group (A ? P = 0.139;Pm ? P = 0.230;and C ? P = 0.191). There was also no statistically significant difference in all 3 assessed indexes between the intermediate AMD subgroup and the control group (A ? P = 0.106, Pm ? P = 0.124, and C ? P = 0.102, respectively). Conclusions: According to our results from the assessment of FAZ in patients with early and intermediate AMD, we hypothesize that macular perfusion remains fairly unchanged in the nonexudative stages of the disease. OCT-A is a reliable technique for visualizing and quantifying FAZ in patients with nonexudative AMD.展开更多
文摘Purpose: To investigate macular morphology by spectral domain optical coherence tomography (SDOCT) in children with history of the retinopathy of prematurity (ROP). Materials and methods: In this cross-sectional study we included 35 eyes of 18 patients, aged 4 to 8 years, with history of ROP. Twenty-one eyes had received treatment for type 1 pre-threshold ROP. The others showed spontaneous regression of the disease. A 7 × 7-mm retinal area was sampled using a 3-dimensional scanning protocol with high-resolution spectral domain optical coherence tomography (SOCT Copernicus REVO). The central foveal thickness, mean macular thickness, macular volume and foveal depression were measured. The macular anatomy and the foveal contour were examined. Results: The mean birth weight was 1338.29 ± 324.05 grams. Mean gestational age at birth was 29.37 ± 2.07 weeks. Twenty-one eyes were treated with laser or cryotherapy. All of them showed regression of the disease. The mean best corrected visual acuity was 20/28. The average central foveal thickness was 262.26 ± 37.39, with 68.57% of preterm > 240 μm and 22.86% > 220 μm. In all eyes, the foveal contour is abnormal. A foveal depression was absent in 25 eyes (71%). Conclusion: In the majority of children with a history of ROP, we found changes in macular morphology, including retention of inner retinal layers and absent foveal depression. In our study foveal hypoplasia was associated with good functional outcome.
文摘Optical coherence tomography-angiography (OCT-A) is a relatively new non-invasive imaging technique which provides three-dimensional visualization of the retinal and choroidal microvasculature. Recently, OCT-A is widely used in the diagnosis of age-related macular degeneration (AMD). Purpose: To compare 3 quantitative indexes of foveal avascular zone (FAZ)—area (A), perimeter (Pm), and circularity (C) in patients with early and intermediate nonexudative AMD and healthy subjects using OCT-A. Methods: Eighty-nine patients with nonexudative AMD (n = 89 eyes) were enrolled in the study. They were compared with sex- and age-matched control group of 66 healthy subjects (n = 66 eyes). The patients with nonexudative AMD were divided into 2 subgroups—early AMD (n = 42 eyes) and intermediate AMD (n = 47 eyes). All participants underwent OCT-A (3 × 3 mm scans, Cirrus HD-OCT, Angioplex, Carl Zeiss Meditec, Dublin, CA). Results: There was no statistically significant difference in all 3 assessed indexes between the early AMD subgroup and the control group (A ? P = 0.139;Pm ? P = 0.230;and C ? P = 0.191). There was also no statistically significant difference in all 3 assessed indexes between the intermediate AMD subgroup and the control group (A ? P = 0.106, Pm ? P = 0.124, and C ? P = 0.102, respectively). Conclusions: According to our results from the assessment of FAZ in patients with early and intermediate AMD, we hypothesize that macular perfusion remains fairly unchanged in the nonexudative stages of the disease. OCT-A is a reliable technique for visualizing and quantifying FAZ in patients with nonexudative AMD.
