Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for...Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD patients.Unfortunately,postoperative recurrence remains a significant challenge.We conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative recurrence.Our experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse endothelium.Selective knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD patients.Mice carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial abnormalities.Intracameral injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant mice.Overall,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development.展开更多
The skip-stop operation strategy （SOS） is rarely applied to Chinese urban rail transit networks because it is a simple scheme and a less universally popular transportation service. However, the SOS has performance a...The skip-stop operation strategy （SOS） is rarely applied to Chinese urban rail transit networks because it is a simple scheme and a less universally popular transportation service. However, the SOS has performance advantages, in that the total trip time can be reduced depending on the number of skipped stations, crowds of passengers can be rapidly evacuated at congested stations in peak periods, and the cost to transit companies is reduced. There is a contradiction between reducing the trip time under the SOS and increasing the passengers＇ waiting times under an all-stop scheme. Given this situation, the three objectives of our study were to minimize the waiting and trip times of all passengers and the travel times of trains. A comprehensive estimation model is presented for the SOS. The mechanism through which the trip time for all passengers is affected by the SOS is analyzed in detail. A 0-I integer programming formulation is established for the three objectives, and is solved using a tabu search algorithm. Finally, an example is presented to demonstrate that the estimation method for the SOS is capable of optimizing the timetable and operation schemes for a Chinese urban rail transit network.展开更多
In this paper,we consider distributed convex optimization problems on multi-agent networks.We develop and analyze the distributed gradient method which allows each agent to compute its dynamic stepsize by utilizing th...In this paper,we consider distributed convex optimization problems on multi-agent networks.We develop and analyze the distributed gradient method which allows each agent to compute its dynamic stepsize by utilizing the time-varying estimate of the local function value at the global optimal solution.Our approach can be applied to both synchronous and asynchronous communication protocols.Specifically,we propose the distributed subgradient with uncoordinated dynamic stepsizes(DS-UD)algorithm for synchronous protocol and the AsynDGD algorithm for asynchronous protocol.Theoretical analysis shows that the proposed algorithms guarantee that all agents reach a consensus on the solution to the multi-agent optimization problem.Moreover,the proposed approach with dynamic stepsizes eliminates the requirement of diminishing stepsize in existing works.Numerical examples of distributed estimation in sensor networks are provided to illustrate the effectiveness of the proposed approach.展开更多
For constrained piecewise linear （PWL） systems, the possible existing model uncertainty will bring the difficulties to the design approaches of model predictive control （MPC） based on mixed integer programming （...For constrained piecewise linear （PWL） systems, the possible existing model uncertainty will bring the difficulties to the design approaches of model predictive control （MPC） based on mixed integer programming （MIP）. This paper combines the robust method and hybrid method to design the MPC for PWL systems with structured uncertainty. For the proposed approach, as the system model is known at current time, a free control move is optimized to be the current control input. Meanwhile, the MPC controller uses a sequence of feedback control laws as the future control actions, where each feedback control law in the sequence corresponds to each partitions and the arbitrary switching technique is adopted to tackle all the possible switching. Furthermore, to reduce the online computational burden of MPC, the segmented design procedure is suggested by utilizing the characteristics of the proposed approach. Then, an offline design algorithm is proposed, and the reserved degree of freedom can be online used to optimize the control input with lower computational burden.展开更多
The Xiaojiang fault system(XJFS), located to the southeast of the Tibetan Plateau, has a complicated tectonic history and is an ideal location to study the Tibetan Plateau in terms of its deep material transport mecha...The Xiaojiang fault system(XJFS), located to the southeast of the Tibetan Plateau, has a complicated tectonic history and is an ideal location to study the Tibetan Plateau in terms of its deep material transport mechanism and the effects of past tectonic events. In this study, broadband and long-period magnetotelluric data were collected above this fault system and inverted to build a 3-D resistivity model of the lithosphere. As shown in the model, at upper-middle crustal depths, three high-resistivity anomalies separate the strike-slip faults located in the study area, which may be the remnants of the Emeishan large igneous province that was destroyed and modified by Cenozoic crustal activity. The lower crust is characterized by significant lowresistivity anomalies that extend downward to the upper mantle. The low-resistivity anomalies in the upper crust may be caused by brines or/and conductive minerals(e.g., graphite and sulfides), and the possible reason for the low-resistivity anomalies that were imaged in the lower crust and upper mantle may be the presence of hydrogen in nominally anhydrous minerals and partial melts. According to the seismic activity distribution and resistivity structure, we propose dividing the seismic activity of the study area into three categories: tectonic earthquakes, earthquakes with no active faults on the surface, and other scattered earthquakes with no general features. Seismic activities are controlled by tectonic activities, fluid transportation, and the adjustment of the Earth's stress field. It is believed that there is a mutually reinforcing relationship between seismic activity and deep fluids. Fluids could lower the frictional force in faults, promote movement, and thus induce earthquakes;on the other hand,seismic activities and the long-term strike-slip movements of faults could generate heat and increase the connectivity of fluids,which decreases the strength of the crust and facilitates the flow of fluids. Based on the resistivity model, it is demonstrated that the present tectonic activity in the XJFS is complicated and characterized by rigid block extrusion along strike-slip faults in the upper crust, ductile deformation with channel flow in the lower crust, and the upwelling of mantle materials. In combination with previous studies, our results indicate that the weak crustal materials from the Tibetan Plateau are blocked by(1) the lithosphere modified by the Emeishan plume and(2) the South China block when flowing through the Sichuan-Yunnan block. Therefore,these weak materials turn to the southwest direction along the XJFS, then pass through the Red River fault and enter the Indochina block.展开更多
基金supported by the Shandong Provincial Natural Science Foundation(ZR2020QH140)the National Natural Science Foundation of China(82101091)+1 种基金the Academic Promotion Program of Shandong First Medical University(2019ZL001,2019RC008)the Shandong Provincial Key Research and Development Program(2021ZDSYS14)。
文摘Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD patients.Unfortunately,postoperative recurrence remains a significant challenge.We conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative recurrence.Our experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse endothelium.Selective knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD patients.Mice carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial abnormalities.Intracameral injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant mice.Overall,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development.
基金financed by the National Basic Research Program of China, under project ID 2012CB725403
文摘The skip-stop operation strategy （SOS） is rarely applied to Chinese urban rail transit networks because it is a simple scheme and a less universally popular transportation service. However, the SOS has performance advantages, in that the total trip time can be reduced depending on the number of skipped stations, crowds of passengers can be rapidly evacuated at congested stations in peak periods, and the cost to transit companies is reduced. There is a contradiction between reducing the trip time under the SOS and increasing the passengers＇ waiting times under an all-stop scheme. Given this situation, the three objectives of our study were to minimize the waiting and trip times of all passengers and the travel times of trains. A comprehensive estimation model is presented for the SOS. The mechanism through which the trip time for all passengers is affected by the SOS is analyzed in detail. A 0-I integer programming formulation is established for the three objectives, and is solved using a tabu search algorithm. Finally, an example is presented to demonstrate that the estimation method for the SOS is capable of optimizing the timetable and operation schemes for a Chinese urban rail transit network.
基金supported by the Key Research and Development Project in Guangdong Province(2020B0101050001)the National Science Foundation of China(61973214,61590924,61963030)the Natural Science Foundation of Shanghai(19ZR1476200)。
文摘In this paper,we consider distributed convex optimization problems on multi-agent networks.We develop and analyze the distributed gradient method which allows each agent to compute its dynamic stepsize by utilizing the time-varying estimate of the local function value at the global optimal solution.Our approach can be applied to both synchronous and asynchronous communication protocols.Specifically,we propose the distributed subgradient with uncoordinated dynamic stepsizes(DS-UD)algorithm for synchronous protocol and the AsynDGD algorithm for asynchronous protocol.Theoretical analysis shows that the proposed algorithms guarantee that all agents reach a consensus on the solution to the multi-agent optimization problem.Moreover,the proposed approach with dynamic stepsizes eliminates the requirement of diminishing stepsize in existing works.Numerical examples of distributed estimation in sensor networks are provided to illustrate the effectiveness of the proposed approach.
基金supported by the National Science Foundation of China(Nos.60934007,61074060,61004062)the China Postdoctoral Science Foundation Special Support(No.201003272)+1 种基金the Shanghai 'Chen Guang' Program(No.10CG30)the Research and innovation project of Shanghai Education Commission(No.11CXY08)
文摘For constrained piecewise linear （PWL） systems, the possible existing model uncertainty will bring the difficulties to the design approaches of model predictive control （MPC） based on mixed integer programming （MIP）. This paper combines the robust method and hybrid method to design the MPC for PWL systems with structured uncertainty. For the proposed approach, as the system model is known at current time, a free control move is optimized to be the current control input. Meanwhile, the MPC controller uses a sequence of feedback control laws as the future control actions, where each feedback control law in the sequence corresponds to each partitions and the arbitrary switching technique is adopted to tackle all the possible switching. Furthermore, to reduce the online computational burden of MPC, the segmented design procedure is suggested by utilizing the characteristics of the proposed approach. Then, an offline design algorithm is proposed, and the reserved degree of freedom can be online used to optimize the control input with lower computational burden.
基金the National Natural Science Foundation of China(52125002)the Research Program of Chongqing Municipal Education Commission(KJZD-K202101502)the Natural Science Foundation of Jiangxi Province(20224ACB203015)。
基金supported by the National Natural Science Foundation of China (Grant Nos. 91755215, 42074081, 42104071)the Science Foundation of Chongqing (Grant No. cstc2021jcyjjqX0018)。
文摘The Xiaojiang fault system(XJFS), located to the southeast of the Tibetan Plateau, has a complicated tectonic history and is an ideal location to study the Tibetan Plateau in terms of its deep material transport mechanism and the effects of past tectonic events. In this study, broadband and long-period magnetotelluric data were collected above this fault system and inverted to build a 3-D resistivity model of the lithosphere. As shown in the model, at upper-middle crustal depths, three high-resistivity anomalies separate the strike-slip faults located in the study area, which may be the remnants of the Emeishan large igneous province that was destroyed and modified by Cenozoic crustal activity. The lower crust is characterized by significant lowresistivity anomalies that extend downward to the upper mantle. The low-resistivity anomalies in the upper crust may be caused by brines or/and conductive minerals(e.g., graphite and sulfides), and the possible reason for the low-resistivity anomalies that were imaged in the lower crust and upper mantle may be the presence of hydrogen in nominally anhydrous minerals and partial melts. According to the seismic activity distribution and resistivity structure, we propose dividing the seismic activity of the study area into three categories: tectonic earthquakes, earthquakes with no active faults on the surface, and other scattered earthquakes with no general features. Seismic activities are controlled by tectonic activities, fluid transportation, and the adjustment of the Earth's stress field. It is believed that there is a mutually reinforcing relationship between seismic activity and deep fluids. Fluids could lower the frictional force in faults, promote movement, and thus induce earthquakes;on the other hand,seismic activities and the long-term strike-slip movements of faults could generate heat and increase the connectivity of fluids,which decreases the strength of the crust and facilitates the flow of fluids. Based on the resistivity model, it is demonstrated that the present tectonic activity in the XJFS is complicated and characterized by rigid block extrusion along strike-slip faults in the upper crust, ductile deformation with channel flow in the lower crust, and the upwelling of mantle materials. In combination with previous studies, our results indicate that the weak crustal materials from the Tibetan Plateau are blocked by(1) the lithosphere modified by the Emeishan plume and(2) the South China block when flowing through the Sichuan-Yunnan block. Therefore,these weak materials turn to the southwest direction along the XJFS, then pass through the Red River fault and enter the Indochina block.
