Decision implication is a form of decision knowledge represen-tation,which is able to avoid generating attribute implications that occur between condition attributes and between decision attributes.Compared with other...Decision implication is a form of decision knowledge represen-tation,which is able to avoid generating attribute implications that occur between condition attributes and between decision attributes.Compared with other forms of decision knowledge representation,decision implication has a stronger knowledge representation capability.Attribute granularization may facilitate the knowledge extraction of different attribute granularity layers and thus is of application significance.Decision implication canonical basis(DICB)is the most compact set of decision implications,which can efficiently represent all knowledge in the decision context.In order to mine all deci-sion information on decision context under attribute granulating,this paper proposes an updated method of DICB.To this end,the paper reduces the update of DICB to the updates of decision premises after deleting an attribute and after adding granulation attributes of some attributes.Based on this,the paper analyzes the changes of decision premises,examines the properties of decision premises,designs an algorithm for incrementally generating DICB,and verifies its effectiveness through experiments.In real life,by using the updated algorithm of DICB,users may obtain all decision knowledge on decision context after attribute granularization.展开更多
While propagating inside the strongly scattering biological tssue,photons lose their incident directions beyond one transport mean free path(TMFP,~1 millimeter(mm)),which makes it challenging to achieve optical focusi...While propagating inside the strongly scattering biological tssue,photons lose their incident directions beyond one transport mean free path(TMFP,~1 millimeter(mm)),which makes it challenging to achieve optical focusing or clear imaging deep inside tissue.By manipulating many degrees of the incident optical wavefront,the latest optical wavefront engineering(WFE)technology compensates the wavelfront distortions caused by the scattering media and thus is toward breaking this physical limit,bringing bright perspective to many applications deep inside tissue,eg,high resolution functional/molecular imaging,optical excitation(optogenetics)and optical tweezers.However,inside the dynamic turbid media such as the biological tissue,the wavefront distortion is a fast and continuously changing process whose decorrelation rate is on timescales from milliseconds(ms)to microseconds(μs),or even faster.This requires that the WFE technology should be capable of beating this rapid process.In this review,we discuss the major challenges faced by the WFE technology due to the fast decorrelation of dynamic turbid media such as living tissue when achieving light focusing/imaging and summarize the research progress achieved to date to overcome these challenges.展开更多
Fuzzy decision implication is an extension of decision implication in the fuzzy setting,serving to uncover the dependencies of fuzzy attributes.This study presents the interpretation of fuzzy decision implication in t...Fuzzy decision implication is an extension of decision implication in the fuzzy setting,serving to uncover the dependencies of fuzzy attributes.This study presents the interpretation of fuzzy decision implication in the fuzzy decision context.Specially,they will show that from fuzzy decision contexts one can obtain a closed fuzzy set of fuzzy decision implications,and the semantical characteristic of the obtained fuzzy set can be interpreted by fuzzy decision context and can be represented by some operators of fuzzy decision context.Conversely,starting from a fuzzy set of fuzzy decision implications,they can form a fuzzy decision context,from which the given fuzzy set can be derived.The result actually implies that they have constructed a correspondence between closed fuzzy sets of fuzzy decision implications and fuzzy decision contexts,and thus shows the equivalence of two interpretations of fuzzy decision implications.展开更多
The last several years have witnessed the prosperous development of zinc-ion batteries(ZIBs),which are considered as a promising competitor of energy storage systems thanks to their low cost and high safety.However,th...The last several years have witnessed the prosperous development of zinc-ion batteries(ZIBs),which are considered as a promising competitor of energy storage systems thanks to their low cost and high safety.However,the reversibility and availability of this system are blighted by problems such as uncontrollable dendritic growth,hydrogen evolution,and corrosion passivation on anode side.A functionally and structurally well-designed anode current collectors(CCs)is believed as a viable solution for those problems,with a lack of summarization according to its working mechanisms.Herein,this review focuses on the challenges of zinc anode and the mechanisms of modified anode CCs,which can be divided into zincophilic modification,structural design,and steering the preferred crystal facet orientation.The possible prospects and directions on zinc anode research and design are proposed at the end to hopefully promote the practical application of ZIBs.展开更多
Objectives: To explore the clinical efficacy and survival of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳ primary hepatocellular carcinoma.Methods: A retrospective study of 62 patien...Objectives: To explore the clinical efficacy and survival of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳ primary hepatocellular carcinoma.Methods: A retrospective study of 62 patients with primary hepatocellular carcinoma in our hospital from January2017 to December 2018 [60 males, 2 females, age(52.76 ± 10.82) years old], All patients were implanted with Iodine-125 radioactive seeds under CT guidance, followed up regularly after operation to observe the clinical efficacy, including comparison of changes in cancer size before and after treatment, tumor marker AFP, and improvement in complications such as abdominal pain and ascites. Follow-up 3–36 months to assess patient survival.Results: Among the 62 patients, 3 months after Iodine-125 radioactive seed implantation, 5 cases(8.1%) had complete remission of cancer, 33 cases(53.2%) had partial remission, 12 cases(19.4%) had stable lesions, and 12 cases(19.4%) had disease progression. The effective rate was 61.3%. The tumor volume(31.44 ± 14.51 cm3) was significantly smaller than before(50.96 ± 30.13 cm3)(t=5.303, p < 0.05). The tumor marker AFP(69.28 ±50.99) ug/L of 3 months after implantation was significantly lower than that before treatment(90.63 ± 68.58)ug/L(t=3.702, P < 0.05). The average survival time of Iodine-125 seed implantation for stageⅣhepatocellular carcinoma is 11.47 ± 0.85 months, and the median survival time is 9 months. The survival time of the group with better pathological differentiation(grade Ⅰ+ⅡⅠ) was significantly better than that of the group with poor differentiation(grade Ⅲ+Ⅳ)(x2=6.869 p < 0.05). Among the 38 patients with different degrees of abdominal pain,22 patients improved better than before;15 of 28 patients with different degrees of ascites were better than before. All patients had no serious complications related to treatment.Conclusions: Iodine-125 radioactive seed implantation therapy can safely and effectively treat hepatocellular carcinoma, and relieve the clinical symptoms of abdominal pain and ascites.展开更多
The acrylonitrile-butadiene-styrene (ABS) surface was etched by dipping it into chromic acid-sulfuric acid containing a trace amount of palladium. The surface roughness, activity, and valence bond were characterized...The acrylonitrile-butadiene-styrene (ABS) surface was etched by dipping it into chromic acid-sulfuric acid containing a trace amount of palladium. The surface roughness, activity, and valence bond were characterized by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The results showed that with the increase of Pd concentration in the etching solution the ABS surface roughness reduced. The ratio of O to C increases and forms a large amount of O=C?O functional groups by dipping into Pd contained etching solution, thus the amount of colloids palladium adsorption increases. The carboxyl group acts as the ad- sorption site for the Pd/Sn catalyst.展开更多
The low-dimensional organic-inorganic halide perovskites with self-trapped exciton emission have promising prospects for single-phase white-light emitters. However, so far, these broadband white-light-emitting(BWLE) p...The low-dimensional organic-inorganic halide perovskites with self-trapped exciton emission have promising prospects for single-phase white-light emitters. However, so far, these broadband white-light-emitting(BWLE) perovskites were synthesized by trial-and-error testing spacing molecules. Here, we developed a steric hindrance regulation strategy to predictably synthesize BWLE perovskites. The molecules containing C–C(–NH_(2))–C groups were introduced into low-dimensional perovskites, which brings a large steric hindrance in-plane orientation. The bigger C–C(–NH_(2))–C bond angle would induce larger structural distortion in perovskites, which leads to the higher rate of self-trapping of excitons and the deeper self-trapping depth. The photoluminescence spectra of the synthesized perovskites can cover the cool-to-warm white light region. Overall, we fabricated a material library consisting of 40 kinds of BWLE compounds according to this strategy. Our findings develop a general strategy to synthesize BWLE perovskites and offer a material platform for optoelectronic applications.展开更多
Dear Editor,Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is a novel subset of coronavirus.To this day,the number of confirmed cases is over 500 milli...Dear Editor,Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is a novel subset of coronavirus.To this day,the number of confirmed cases is over 500 million with more than 6 million deaths globally.SARSCoV-2 keeps on evolving into different variants,including Alpha,Beta,Gamma,Delta,and Omicron.展开更多
Atomistic mechanisms of frictional energy dissipation have attracted significant attention.However,the dynamics of phonon excitation and dissipation remain elusive for many friction processes.Through systematic fast F...Atomistic mechanisms of frictional energy dissipation have attracted significant attention.However,the dynamics of phonon excitation and dissipation remain elusive for many friction processes.Through systematic fast Fourier transform(FFT)analyses of the frictional signals as a silicon tip sliding over a graphite surface at different angles and velocities,we experimentally demonstrate that friction mainly excites non-equilibrium phonons at the washboard frequency and its harmonics.Using molecular dynamics(MD)simulations,we further disclose the phononic origin of structural lubrication,i.e.,the drastic reduction of friction force as the contact angle between two commensurate surfaces changes.In commensurate contacting states,friction excites a large amount of phonons at the washboard frequency and many orders of its harmonics that perfectly match each other in the sliding tip and substrate,while for incommensurate cases,only limited phonons are generated at mismatched washboard frequencies and few low order harmonics in the tip and substrate.展开更多
Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective inve...Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival.展开更多
Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected pa...Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.展开更多
近年来,贵金属钌(Ru)因其具备与铂(Pt)媲美的氢吸附能以及比铂更低的价格被认为是很有前景的氢氧化反应(HOR)和析氢反应(HER)催化剂.然而,目前钌基催化剂在HOR和HER上的大规模应用依然受限于其活性低、稳定性不高等缺点.本文采用湿化学...近年来,贵金属钌(Ru)因其具备与铂(Pt)媲美的氢吸附能以及比铂更低的价格被认为是很有前景的氢氧化反应(HOR)和析氢反应(HER)催化剂.然而,目前钌基催化剂在HOR和HER上的大规模应用依然受限于其活性低、稳定性不高等缺点.本文采用湿化学和热处理结合策略制备了具有Ru/RuO_(2)界面的二维雪花纳米片(Ru/RuO_(2) SNSs).表征和理论计算结果表明, Ru/RuO_(2) SNSs的界面结构与热处理温度密切相关.因此,可通过改变热处理温度调控界Ru/RuO_(2)界面相互作用,并进一步调控催化剂表面的氢结合能(HBE)和氢氧根结合能(OHBE),从而提高HOR和HER的催化性能.当Ru/RuO-12 SNSs用于催化碱性HOR时,在50 mV的过电位为下,其质量活性达到了9.13 A mgRu,分别是Ru SNSs(0.14 A mg^(-1)_(Ru))、RuO_(2) SNSs(0.03 A mg^(-1)_(Ru))和商用Pt/C(0.43 A mg^(-1)_(Ru))的65倍、304倍和21倍.此外, Ru/RuO_(2) SNSs还表现出优异的碱性HER性能.在1 mol L^(-1) KOH中,当电流密度达到10 mA cm^(-2)时,过电位低至20.2 mV.这项工作不仅开发了一种高效的HOR和HER催化剂,而且对开发新型高效催化剂也起到了重要的推动作用.展开更多
基金supported by the National Natural Science Foundation of China (Nos.61972238,62072294).
文摘Decision implication is a form of decision knowledge represen-tation,which is able to avoid generating attribute implications that occur between condition attributes and between decision attributes.Compared with other forms of decision knowledge representation,decision implication has a stronger knowledge representation capability.Attribute granularization may facilitate the knowledge extraction of different attribute granularity layers and thus is of application significance.Decision implication canonical basis(DICB)is the most compact set of decision implications,which can efficiently represent all knowledge in the decision context.In order to mine all deci-sion information on decision context under attribute granulating,this paper proposes an updated method of DICB.To this end,the paper reduces the update of DICB to the updates of decision premises after deleting an attribute and after adding granulation attributes of some attributes.Based on this,the paper analyzes the changes of decision premises,examines the properties of decision premises,designs an algorithm for incrementally generating DICB,and verifies its effectiveness through experiments.In real life,by using the updated algorithm of DICB,users may obtain all decision knowledge on decision context after attribute granularization.
文摘While propagating inside the strongly scattering biological tssue,photons lose their incident directions beyond one transport mean free path(TMFP,~1 millimeter(mm)),which makes it challenging to achieve optical focusing or clear imaging deep inside tissue.By manipulating many degrees of the incident optical wavefront,the latest optical wavefront engineering(WFE)technology compensates the wavelfront distortions caused by the scattering media and thus is toward breaking this physical limit,bringing bright perspective to many applications deep inside tissue,eg,high resolution functional/molecular imaging,optical excitation(optogenetics)and optical tweezers.However,inside the dynamic turbid media such as the biological tissue,the wavefront distortion is a fast and continuously changing process whose decorrelation rate is on timescales from milliseconds(ms)to microseconds(μs),or even faster.This requires that the WFE technology should be capable of beating this rapid process.In this review,we discuss the major challenges faced by the WFE technology due to the fast decorrelation of dynamic turbid media such as living tissue when achieving light focusing/imaging and summarize the research progress achieved to date to overcome these challenges.
基金The National Natural Science Foundation of China(no.61806116)the Natural Science Foundation of Shanxi Province(nos.201801D221175 and 201601D021076)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(STIP)(no.201802014).
文摘Fuzzy decision implication is an extension of decision implication in the fuzzy setting,serving to uncover the dependencies of fuzzy attributes.This study presents the interpretation of fuzzy decision implication in the fuzzy decision context.Specially,they will show that from fuzzy decision contexts one can obtain a closed fuzzy set of fuzzy decision implications,and the semantical characteristic of the obtained fuzzy set can be interpreted by fuzzy decision context and can be represented by some operators of fuzzy decision context.Conversely,starting from a fuzzy set of fuzzy decision implications,they can form a fuzzy decision context,from which the given fuzzy set can be derived.The result actually implies that they have constructed a correspondence between closed fuzzy sets of fuzzy decision implications and fuzzy decision contexts,and thus shows the equivalence of two interpretations of fuzzy decision implications.
基金supported by the National Natural Science Foundation of China(Grant Nos.51874110 and 51604089)Natural Science Foundation of Heilongjiang Province(YQ2021B004)Open Project of State Key Laboratory of Urban Water Resource and Environment(Grant No.QA202138).
文摘The last several years have witnessed the prosperous development of zinc-ion batteries(ZIBs),which are considered as a promising competitor of energy storage systems thanks to their low cost and high safety.However,the reversibility and availability of this system are blighted by problems such as uncontrollable dendritic growth,hydrogen evolution,and corrosion passivation on anode side.A functionally and structurally well-designed anode current collectors(CCs)is believed as a viable solution for those problems,with a lack of summarization according to its working mechanisms.Herein,this review focuses on the challenges of zinc anode and the mechanisms of modified anode CCs,which can be divided into zincophilic modification,structural design,and steering the preferred crystal facet orientation.The possible prospects and directions on zinc anode research and design are proposed at the end to hopefully promote the practical application of ZIBs.
文摘Objectives: To explore the clinical efficacy and survival of CT-guided Iodine-125 radioactive seed implantation in the treatment of stage Ⅳ primary hepatocellular carcinoma.Methods: A retrospective study of 62 patients with primary hepatocellular carcinoma in our hospital from January2017 to December 2018 [60 males, 2 females, age(52.76 ± 10.82) years old], All patients were implanted with Iodine-125 radioactive seeds under CT guidance, followed up regularly after operation to observe the clinical efficacy, including comparison of changes in cancer size before and after treatment, tumor marker AFP, and improvement in complications such as abdominal pain and ascites. Follow-up 3–36 months to assess patient survival.Results: Among the 62 patients, 3 months after Iodine-125 radioactive seed implantation, 5 cases(8.1%) had complete remission of cancer, 33 cases(53.2%) had partial remission, 12 cases(19.4%) had stable lesions, and 12 cases(19.4%) had disease progression. The effective rate was 61.3%. The tumor volume(31.44 ± 14.51 cm3) was significantly smaller than before(50.96 ± 30.13 cm3)(t=5.303, p < 0.05). The tumor marker AFP(69.28 ±50.99) ug/L of 3 months after implantation was significantly lower than that before treatment(90.63 ± 68.58)ug/L(t=3.702, P < 0.05). The average survival time of Iodine-125 seed implantation for stageⅣhepatocellular carcinoma is 11.47 ± 0.85 months, and the median survival time is 9 months. The survival time of the group with better pathological differentiation(grade Ⅰ+ⅡⅠ) was significantly better than that of the group with poor differentiation(grade Ⅲ+Ⅳ)(x2=6.869 p < 0.05). Among the 38 patients with different degrees of abdominal pain,22 patients improved better than before;15 of 28 patients with different degrees of ascites were better than before. All patients had no serious complications related to treatment.Conclusions: Iodine-125 radioactive seed implantation therapy can safely and effectively treat hepatocellular carcinoma, and relieve the clinical symptoms of abdominal pain and ascites.
基金the National Doctorial Research Foundation of China (No.20030213007).
文摘The acrylonitrile-butadiene-styrene (ABS) surface was etched by dipping it into chromic acid-sulfuric acid containing a trace amount of palladium. The surface roughness, activity, and valence bond were characterized by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The results showed that with the increase of Pd concentration in the etching solution the ABS surface roughness reduced. The ratio of O to C increases and forms a large amount of O=C?O functional groups by dipping into Pd contained etching solution, thus the amount of colloids palladium adsorption increases. The carboxyl group acts as the ad- sorption site for the Pd/Sn catalyst.
基金financial support from National Natural Science Foundation of China(21905154)and the Taishan Scholars Program.the Fundamental Research Funds for the Central Universities in China(020514380231021014380177)+3 种基金the National Natural Science Foundation of China(2217304421873048)the National Key R&D Program of China No.2020YFA0406104“Innovation&Entrepreneurship Talents Plan”of Jiangsu Province.
文摘The low-dimensional organic-inorganic halide perovskites with self-trapped exciton emission have promising prospects for single-phase white-light emitters. However, so far, these broadband white-light-emitting(BWLE) perovskites were synthesized by trial-and-error testing spacing molecules. Here, we developed a steric hindrance regulation strategy to predictably synthesize BWLE perovskites. The molecules containing C–C(–NH_(2))–C groups were introduced into low-dimensional perovskites, which brings a large steric hindrance in-plane orientation. The bigger C–C(–NH_(2))–C bond angle would induce larger structural distortion in perovskites, which leads to the higher rate of self-trapping of excitons and the deeper self-trapping depth. The photoluminescence spectra of the synthesized perovskites can cover the cool-to-warm white light region. Overall, we fabricated a material library consisting of 40 kinds of BWLE compounds according to this strategy. Our findings develop a general strategy to synthesize BWLE perovskites and offer a material platform for optoelectronic applications.
基金funded by the National Program on Key Research Project of China(2020YFC0860100)National Nature Funds(31870156 and 81801583).
文摘Dear Editor,Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is a novel subset of coronavirus.To this day,the number of confirmed cases is over 500 million with more than 6 million deaths globally.SARSCoV-2 keeps on evolving into different variants,including Alpha,Beta,Gamma,Delta,and Omicron.
基金National Natural Science Foundation of China(Grant Nos.52035003,52065037,51575104,and 52175161)the China Postdoctoral Science Foundation(Grant No.2021MD703810)+1 种基金the Postdoctoral Science Foundation of Gansu Academy of Sciences(Grant No.BSH202101)the Southeast University“Zhongying Young Scholars”Project for financial support.
文摘Atomistic mechanisms of frictional energy dissipation have attracted significant attention.However,the dynamics of phonon excitation and dissipation remain elusive for many friction processes.Through systematic fast Fourier transform(FFT)analyses of the frictional signals as a silicon tip sliding over a graphite surface at different angles and velocities,we experimentally demonstrate that friction mainly excites non-equilibrium phonons at the washboard frequency and its harmonics.Using molecular dynamics(MD)simulations,we further disclose the phononic origin of structural lubrication,i.e.,the drastic reduction of friction force as the contact angle between two commensurate surfaces changes.In commensurate contacting states,friction excites a large amount of phonons at the washboard frequency and many orders of its harmonics that perfectly match each other in the sliding tip and substrate,while for incommensurate cases,only limited phonons are generated at mismatched washboard frequencies and few low order harmonics in the tip and substrate.
基金supported by the State Key Project on Inflectional Disease of China(2012ZX10002016-004,2012ZX 10002010-001-004)the Chinese Ministry of Public Health for Key Clinical Projects(439,2010)to Prof.Xiaoping Chenthe National Natural Science Foundation of China(81502524)to Dr.Binhao Zhang
文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival.
文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.
基金supported by the National Key R&D Program of China(2020YFB1505802)the Ministry of Science and Technology of China(2017YFA0208200,2016YFA0204100)+4 种基金the National Natural Science Foundation of China(22025108,U21A20327,and22121001)China Postdoctoral Science Foundation(2020M682083)Guangdong Provincial Natural Science Fund for Distinguished Young Scholars(2021B1515020081)Start-up Support from Xiamen University and the Guangzhou Key Laboratory of Low Dimensional Materials and Energy Storage Devices(20195010002)。
文摘近年来,贵金属钌(Ru)因其具备与铂(Pt)媲美的氢吸附能以及比铂更低的价格被认为是很有前景的氢氧化反应(HOR)和析氢反应(HER)催化剂.然而,目前钌基催化剂在HOR和HER上的大规模应用依然受限于其活性低、稳定性不高等缺点.本文采用湿化学和热处理结合策略制备了具有Ru/RuO_(2)界面的二维雪花纳米片(Ru/RuO_(2) SNSs).表征和理论计算结果表明, Ru/RuO_(2) SNSs的界面结构与热处理温度密切相关.因此,可通过改变热处理温度调控界Ru/RuO_(2)界面相互作用,并进一步调控催化剂表面的氢结合能(HBE)和氢氧根结合能(OHBE),从而提高HOR和HER的催化性能.当Ru/RuO-12 SNSs用于催化碱性HOR时,在50 mV的过电位为下,其质量活性达到了9.13 A mgRu,分别是Ru SNSs(0.14 A mg^(-1)_(Ru))、RuO_(2) SNSs(0.03 A mg^(-1)_(Ru))和商用Pt/C(0.43 A mg^(-1)_(Ru))的65倍、304倍和21倍.此外, Ru/RuO_(2) SNSs还表现出优异的碱性HER性能.在1 mol L^(-1) KOH中,当电流密度达到10 mA cm^(-2)时,过电位低至20.2 mV.这项工作不仅开发了一种高效的HOR和HER催化剂,而且对开发新型高效催化剂也起到了重要的推动作用.