In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials i...In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials is similar to those of horseradish peroxidase(HRP),Fe_(3)O_(4)nanomaterials are also used as peroxidase mimics and have achieved a certain development in many fields based on latest research results.To improve the stability and catalytic ability of simple Fe_(3)O_(4)nanomaterials,various modification strategies of Fe_(3)O_(4)nanomaterials have been developed.The recent advances of these strategies have been presented and discussed.In addition,this paper introduces the application of Fe_(3)O_(4)nanozymes in the detection of food and industrial pollutants,as well as in the field of biosafety.展开更多
OBJECTIVE： To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS： We searched online databases： Chinese journal full-text da...OBJECTIVE： To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS： We searched online databases： Chinese journal full-text database, China National Knowledge Infrastructure, Wanfang database, Chinese journal full-text database, Pubmed, ScienceDirect,Embase, and the Cochrane Library with manual-screening of relevant literature. Eligible randomized controlled trials（RCT） on angina pectoris were included. We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration. We treated the relief rate of angina symptoms and electrocardiograph（ECG） as evaluation.RESULTS： Seven articles, including in 1134 patients, were enrolled after the evaluation. Therewas no significant heterogeneity among the studies（χ2=1.08, df=6, P=0.98, I2=0%）. The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris [odds ratio（OR）=2.95, 95%（CI）（1.81, 4.81）] and improving ischemic ECG [OR=2.85, 95% CI（1.67, 4.86）]. The difference was statistically significant in the ＂80 mg dosage＂ and ＂100 mg dosage＂ subgroups（P0.05） for improving clinical symptoms and ECG. The funnel graphic was nearly symmetrical. Sensitivity analysis suggested that the results were stable.CONCLUSION： Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone. However, the conclusions should be interpreted with care until more high-quality RCTs are reported.展开更多
基金the financial support from the National Natural Science Foundation of China(Nos.31901799,21705060,21605105 and 32001804)the Natural Science Foundation of Jiangsu Province,China(Nos.BK20211340 and BK20180979)+1 种基金Opening Project of Key Laboratory of Impurity Spectrum of Chemical Drug,China(No.NMPA-KLIPCD-2020-09)the Emerging science and technology innovation team funding of JUST(No.1182921902)。
文摘In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials is similar to those of horseradish peroxidase(HRP),Fe_(3)O_(4)nanomaterials are also used as peroxidase mimics and have achieved a certain development in many fields based on latest research results.To improve the stability and catalytic ability of simple Fe_(3)O_(4)nanomaterials,various modification strategies of Fe_(3)O_(4)nanomaterials have been developed.The recent advances of these strategies have been presented and discussed.In addition,this paper introduces the application of Fe_(3)O_(4)nanozymes in the detection of food and industrial pollutants,as well as in the field of biosafety.
基金Supported by Liaoning Province Science and Technology Plan Projects,Traditional Chinese Medicine Efficacy Evaluation Key Technology Research(No.2010225034)and(No.2010ZX09401-304)
文摘OBJECTIVE： To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS： We searched online databases： Chinese journal full-text database, China National Knowledge Infrastructure, Wanfang database, Chinese journal full-text database, Pubmed, ScienceDirect,Embase, and the Cochrane Library with manual-screening of relevant literature. Eligible randomized controlled trials（RCT） on angina pectoris were included. We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration. We treated the relief rate of angina symptoms and electrocardiograph（ECG） as evaluation.RESULTS： Seven articles, including in 1134 patients, were enrolled after the evaluation. Therewas no significant heterogeneity among the studies（χ2=1.08, df=6, P=0.98, I2=0%）. The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris [odds ratio（OR）=2.95, 95%（CI）（1.81, 4.81）] and improving ischemic ECG [OR=2.85, 95% CI（1.67, 4.86）]. The difference was statistically significant in the ＂80 mg dosage＂ and ＂100 mg dosage＂ subgroups（P0.05） for improving clinical symptoms and ECG. The funnel graphic was nearly symmetrical. Sensitivity analysis suggested that the results were stable.CONCLUSION： Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone. However, the conclusions should be interpreted with care until more high-quality RCTs are reported.
