Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol o...Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol optical thickness(AOT),and wind speed(WS)in the Bohai Sea were analyzed from the perspective of time domain and frequency domain.Results indicate that the frequency domain analysis was more conducive to revealing the correlations between Chl a and environmental factors.The spatial pattern of time-domain correlations was similar to the isobaths of the Bohai Sea,which was positive in shallow waters and negative in deep waters for SST,PAR,and AOT,and was reversed for WS.Frequency-domain correlations were obtained by performing Fourier Transform and were higher than correlations in time domain.The spatial distributions indicated that the effects of SST and PAR on Chl a were greater than AOT and WS in the Bohai Sea.Additionally,cross-spectrum analysis was applied to explore the response relationships.A depth-dependent pattern was shown in correlations and time lags,indicating that the influential mechanism of environmental factors on Chl-a concentration is related to seawater depth.展开更多
This study explores the significance,current research landscape,and conceptualization of sports safety promotion.Safety in sports is fundamental to youth physical activities,and an excessive focus on or neglect of saf...This study explores the significance,current research landscape,and conceptualization of sports safety promotion.Safety in sports is fundamental to youth physical activities,and an excessive focus on or neglect of safety is unwarranted.Globally,numerous countries have extensively researched sports safety promotion and implemented diverse strategies.Drawing from KABP(Knowledge,Attitude,Behavior,Practice)theory and 4M(Man,Machine,Medium,Management)management,this paper presents a conceptual framework for sports safety promotion.It integrates these theories to devise a comprehensive accident prevention model within a sports safety promotion system.The framework prioritizes enhancing students’safety literacy and underscores the practical application of safety knowledge and skills in simulated sports settings following structured safety education.It aims to enhance students’competency and proficiency in averting sports-related injuries.展开更多
Cobalt phthalocyanine-graphene （CoPc-Gr） complex are fabricated through 7r-Tr interaction of each components, with CoPc adsorbed/inserted on/in the graphene sheets. The obtained complex could be used in the electro-...Cobalt phthalocyanine-graphene （CoPc-Gr） complex are fabricated through 7r-Tr interaction of each components, with CoPc adsorbed/inserted on/in the graphene sheets. The obtained complex could be used in the electro-chemical detection of various medicines. CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine （DA） and ascorbic acid （AA）, much better than those of CoPc, graphene oxide （GrO） or graphene （Gr） modified electrode. Significantly, the detection of dopamine is a diffusion-controlled process, highly selective, and has a low detection limit and broad linear range.展开更多
In order to explore the genomic basis for liver cancer metastasis,whole-exome sequencing(WES)was performed on patient-derived hepatocellular carcinoma(HCC)cell lines with differential metastatic potentials and analyze...In order to explore the genomic basis for liver cancer metastasis,whole-exome sequencing(WES)was performed on patient-derived hepatocellular carcinoma(HCC)cell lines with differential metastatic potentials and analyzed their clonal evolution relationships.An evolutionary tree based on genomic single nucleotide polymorphism(SNP)was constructed in MegaX software.The WES data showed that the average percentage of heterogeneous mutations in each HCC cell lines was 16.55%(range,15.38%e18.17%).C:G>T:A and T:A>C:G somatic transitions were the two most frequent substitutions.In these metastatic HCC cell lines,non-silent gene mutations were found in 21.88%of known driver genes and 10 classical signaling pathways.The protein interaction network was constructed by STRING,and hub genes were found in the shared trunk mutation genes and the heterogeneous branch mutations respectively.In cBioPortal database,some of the selected hub genes were found to be associated with poor overall survival(OS)of HCC patients.Among the mutated HCC driver genes,a novel KEAP1 mutation with a homozygous frameshift truncation at the c-terminal Nrf2 binding region was detected and verified in MHCC97-H and HCC97LM3 cells.In conclusion,WES data demonstrate that HCC cell lines from tumor biopsy specimens of the same patient have obtained different metastatic potentials through repeated selection in rodents in vivo,and they do indeed have a genetic relationship at the genomic level.展开更多
Introduction:Analyze the recent epidemiological and temporal-spatial characteristics of human brucellosis in China and provide information for adjusting strategies for brucellosis control.Methods:Human brucellosis dat...Introduction:Analyze the recent epidemiological and temporal-spatial characteristics of human brucellosis in China and provide information for adjusting strategies for brucellosis control.Methods:Human brucellosis data were obtained from the National Notifiable Disease Reporting System(NNDRS).A geographical information system(GIS)was used to visualize high-risk areas with annual incidence based on county(district)polygons.The space-time scan statistic(STSS)was applied to detect the space-time clusters of human brucellosis.Results:A total of 69,767 cases were reported from 2,083 counties in the mainland of China in 2021,a 47.7%increase from 2020(47,425).About 95.5%of the total cases were centralized in northern China and 31.8%in Inner Mongolia(IM).The number of counties with an incidence exceeding 100 per 100,000 was 34 in 2020 and 65 in 2021.From 2020 to 2021,24 space-time clusters were detected.The two primary clusters were located northeast of IM,including 109 counties.The secondary clusters affected 208 counties in 2020 and spread to 297 counties in 2021,the majority of which were located in the middle of IM,exhibiting a trend spreading west from IM to neighboring provincial-level administrative divisions(PLADs).Conclusions:From 2020 to 2021,the incidence of human brucellosis nationwide was exponential,demonstrating distinct spatiotemporal characteristics.Space-time clusters were located in IM and neighboring areas.Therefore,considerable efforts are required to curb this momentum.展开更多
Introduction:Brucellosis is an important zoonotic infectious disease with its main mode of transmission from livestock to humans.The study analyzed epidemiological characteristics of human brucellosis from 2016 to 201...Introduction:Brucellosis is an important zoonotic infectious disease with its main mode of transmission from livestock to humans.The study analyzed epidemiological characteristics of human brucellosis from 2016 to 2019 in China,aiming to understand progress of the National Program of Brucellosis Prevention and Control.Methods:The research obtained data on human brucellosis cases reported through China’s National Notifiable Disease Reporting System(NNDRS)from January 1,2016 to December 31,2019 and described brucellosis epidemiological patterns by region,seasonality,age,sex,and occupation.Results:The number of cases reported nationwide in China decreased from 47,139(3.4/100,000)in 2016 to 37,947(2.7/100,000)in 2018,and then increased to 44,036(3.2/100,000)in 2019,with an average annual incidence of 3.0/100,000 during the four study years.Brucellosis in Xinjiang declined from 35.6/100,000 in 2016 to 16.3/100,000 in 2019-an average annual decrease of 22.9%.Brucellosis in Inner Mongolia increased from 23.8/100,000 in 2016 to 54.4/100,000 in 2019-an average increase of 31.8%per year and accounting for 22%of all reported cases.Northern China reported 95.2%of cases during this period and still had an incidence of 7.2/100,000 and 87.0%of counties being affected by brucellosis in 2019.In this region in 2019,males aged 45-64 years old had an incidence of over 15.9/100,000,compared with over 7.0/100,000 among females aged 45-64 years old.Conclusions:Although there was progress in prevention and control of human brucellosis in some provincial-level administrative divisions(PLADs)in 2016 through 2019,progress was limited nationwide and there was an overall resurgence of brucellosis in 2019.The resurgence was primarily in Inner Mongolia.An One Health approach should be strengthened to ensure successful and sustainable brucellosis prevention and control in China.展开更多
Summary What is already known about this topic?Although fatal once clinical signs appear,rabies is preventable through three proven,effective interventions including mass dog vaccination,postexposure prophylaxis(PEP),...Summary What is already known about this topic?Although fatal once clinical signs appear,rabies is preventable through three proven,effective interventions including mass dog vaccination,postexposure prophylaxis(PEP),and,though sometimes neglected,awareness of rabies.What is added by this report?The total awareness rate of rabies-related knowledge among rural residents was only 57.9%in Guangxi Zhuang Autonomous Region,one of the provinciallevel administrative divisions(PLADs)with endemic rabies in China.展开更多
Summary What is already known about this topic?Rabies is fatal while preventable.More than 99%of human rabies cases were caused by dog bites worldwide.Mass dog vaccination could interrupt dogmediated rabies if achievi...Summary What is already known about this topic?Rabies is fatal while preventable.More than 99%of human rabies cases were caused by dog bites worldwide.Mass dog vaccination could interrupt dogmediated rabies if achieving and maintaining a minimum coverage rate of 70%.What does this report contribute?The results of this study show that roughly 23.7%of households owned dogs in Guangxi Zhuang Autonomous Region.展开更多
基金Supported by the Key Research and Development Program of 14 th Five year Plan of China(No.2021YFC3200401-04)the Major Scientific and Technological Projects of Tianjin(No.18 ZXRHSF00270)。
文摘Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol optical thickness(AOT),and wind speed(WS)in the Bohai Sea were analyzed from the perspective of time domain and frequency domain.Results indicate that the frequency domain analysis was more conducive to revealing the correlations between Chl a and environmental factors.The spatial pattern of time-domain correlations was similar to the isobaths of the Bohai Sea,which was positive in shallow waters and negative in deep waters for SST,PAR,and AOT,and was reversed for WS.Frequency-domain correlations were obtained by performing Fourier Transform and were higher than correlations in time domain.The spatial distributions indicated that the effects of SST and PAR on Chl a were greater than AOT and WS in the Bohai Sea.Additionally,cross-spectrum analysis was applied to explore the response relationships.A depth-dependent pattern was shown in correlations and time lags,indicating that the influential mechanism of environmental factors on Chl-a concentration is related to seawater depth.
文摘This study explores the significance,current research landscape,and conceptualization of sports safety promotion.Safety in sports is fundamental to youth physical activities,and an excessive focus on or neglect of safety is unwarranted.Globally,numerous countries have extensively researched sports safety promotion and implemented diverse strategies.Drawing from KABP(Knowledge,Attitude,Behavior,Practice)theory and 4M(Man,Machine,Medium,Management)management,this paper presents a conceptual framework for sports safety promotion.It integrates these theories to devise a comprehensive accident prevention model within a sports safety promotion system.The framework prioritizes enhancing students’safety literacy and underscores the practical application of safety knowledge and skills in simulated sports settings following structured safety education.It aims to enhance students’competency and proficiency in averting sports-related injuries.
基金supported by the National Natural Science Foundation of China (Grant No. 20773121 and No. 21176221)the National Basic Research in "Climbing" Program of China (Grant No. 2011CB201402)
文摘Cobalt phthalocyanine-graphene （CoPc-Gr） complex are fabricated through 7r-Tr interaction of each components, with CoPc adsorbed/inserted on/in the graphene sheets. The obtained complex could be used in the electro-chemical detection of various medicines. CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine （DA） and ascorbic acid （AA）, much better than those of CoPc, graphene oxide （GrO） or graphene （Gr） modified electrode. Significantly, the detection of dopamine is a diffusion-controlled process, highly selective, and has a low detection limit and broad linear range.
基金This work was supported by the National Natural Science Foundation of China(NSFC,NO.81172066,NO.81472858NO.91529103)+1 种基金Innovation Team Fund of Second Affiliated Hospital of Chongqing Medical UniversityThe authors would like to thank Dr.Zhou-You Tang,Professor&Director,Liver Cancer Institute,Fudan University,for providing the three HCC cell lines(MHCC97-L,MHCC97-H,HCC97LM3).
文摘In order to explore the genomic basis for liver cancer metastasis,whole-exome sequencing(WES)was performed on patient-derived hepatocellular carcinoma(HCC)cell lines with differential metastatic potentials and analyzed their clonal evolution relationships.An evolutionary tree based on genomic single nucleotide polymorphism(SNP)was constructed in MegaX software.The WES data showed that the average percentage of heterogeneous mutations in each HCC cell lines was 16.55%(range,15.38%e18.17%).C:G>T:A and T:A>C:G somatic transitions were the two most frequent substitutions.In these metastatic HCC cell lines,non-silent gene mutations were found in 21.88%of known driver genes and 10 classical signaling pathways.The protein interaction network was constructed by STRING,and hub genes were found in the shared trunk mutation genes and the heterogeneous branch mutations respectively.In cBioPortal database,some of the selected hub genes were found to be associated with poor overall survival(OS)of HCC patients.Among the mutated HCC driver genes,a novel KEAP1 mutation with a homozygous frameshift truncation at the c-terminal Nrf2 binding region was detected and verified in MHCC97-H and HCC97LM3 cells.In conclusion,WES data demonstrate that HCC cell lines from tumor biopsy specimens of the same patient have obtained different metastatic potentials through repeated selection in rodents in vivo,and they do indeed have a genetic relationship at the genomic level.
基金Public Health Emergency Response Mechanism Operation Program of Chinese Center for Disease Control and Prevention(131031001000210001)National Science and Technology Major Project of China(2018ZX10101002-003-002).
文摘Introduction:Analyze the recent epidemiological and temporal-spatial characteristics of human brucellosis in China and provide information for adjusting strategies for brucellosis control.Methods:Human brucellosis data were obtained from the National Notifiable Disease Reporting System(NNDRS).A geographical information system(GIS)was used to visualize high-risk areas with annual incidence based on county(district)polygons.The space-time scan statistic(STSS)was applied to detect the space-time clusters of human brucellosis.Results:A total of 69,767 cases were reported from 2,083 counties in the mainland of China in 2021,a 47.7%increase from 2020(47,425).About 95.5%of the total cases were centralized in northern China and 31.8%in Inner Mongolia(IM).The number of counties with an incidence exceeding 100 per 100,000 was 34 in 2020 and 65 in 2021.From 2020 to 2021,24 space-time clusters were detected.The two primary clusters were located northeast of IM,including 109 counties.The secondary clusters affected 208 counties in 2020 and spread to 297 counties in 2021,the majority of which were located in the middle of IM,exhibiting a trend spreading west from IM to neighboring provincial-level administrative divisions(PLADs).Conclusions:From 2020 to 2021,the incidence of human brucellosis nationwide was exponential,demonstrating distinct spatiotemporal characteristics.Space-time clusters were located in IM and neighboring areas.Therefore,considerable efforts are required to curb this momentum.
基金This work was supported by National Science and Technology Major Project of China(2018ZX10101002-003-002).
文摘Introduction:Brucellosis is an important zoonotic infectious disease with its main mode of transmission from livestock to humans.The study analyzed epidemiological characteristics of human brucellosis from 2016 to 2019 in China,aiming to understand progress of the National Program of Brucellosis Prevention and Control.Methods:The research obtained data on human brucellosis cases reported through China’s National Notifiable Disease Reporting System(NNDRS)from January 1,2016 to December 31,2019 and described brucellosis epidemiological patterns by region,seasonality,age,sex,and occupation.Results:The number of cases reported nationwide in China decreased from 47,139(3.4/100,000)in 2016 to 37,947(2.7/100,000)in 2018,and then increased to 44,036(3.2/100,000)in 2019,with an average annual incidence of 3.0/100,000 during the four study years.Brucellosis in Xinjiang declined from 35.6/100,000 in 2016 to 16.3/100,000 in 2019-an average annual decrease of 22.9%.Brucellosis in Inner Mongolia increased from 23.8/100,000 in 2016 to 54.4/100,000 in 2019-an average increase of 31.8%per year and accounting for 22%of all reported cases.Northern China reported 95.2%of cases during this period and still had an incidence of 7.2/100,000 and 87.0%of counties being affected by brucellosis in 2019.In this region in 2019,males aged 45-64 years old had an incidence of over 15.9/100,000,compared with over 7.0/100,000 among females aged 45-64 years old.Conclusions:Although there was progress in prevention and control of human brucellosis in some provincial-level administrative divisions(PLADs)in 2016 through 2019,progress was limited nationwide and there was an overall resurgence of brucellosis in 2019.The resurgence was primarily in Inner Mongolia.An One Health approach should be strengthened to ensure successful and sustainable brucellosis prevention and control in China.
文摘Summary What is already known about this topic?Although fatal once clinical signs appear,rabies is preventable through three proven,effective interventions including mass dog vaccination,postexposure prophylaxis(PEP),and,though sometimes neglected,awareness of rabies.What is added by this report?The total awareness rate of rabies-related knowledge among rural residents was only 57.9%in Guangxi Zhuang Autonomous Region,one of the provinciallevel administrative divisions(PLADs)with endemic rabies in China.
文摘Summary What is already known about this topic?Rabies is fatal while preventable.More than 99%of human rabies cases were caused by dog bites worldwide.Mass dog vaccination could interrupt dogmediated rabies if achieving and maintaining a minimum coverage rate of 70%.What does this report contribute?The results of this study show that roughly 23.7%of households owned dogs in Guangxi Zhuang Autonomous Region.
