A new sesquiterpenoid, 1β,5α-guaiane-4β,10α-diol-6-one （1）, was isolated from 70% EtOH extract of the rhizomes of Acorus calamus. The structure was determined on spectroscopic methods, especially 2D NMR techniqu...A new sesquiterpenoid, 1β,5α-guaiane-4β,10α-diol-6-one （1）, was isolated from 70% EtOH extract of the rhizomes of Acorus calamus. The structure was determined on spectroscopic methods, especially 2D NMR techniques. The absolute configuration of 1 was confirmed by TDDFT quantum chemical calculation of its ECD spectrum. Compound 1 showed promising anti-diabetic activity on a insulin-mediated glucose consumption model of HepG2 cells.展开更多
基金supported by the National Natural Science Foundation of China(No30801429)Zhejiang Provincial Administration of Traditional Chinese Medicine Project(No2012ZZ009)Traditional Chinese Medicine Administration of Zhejiang Province(2010ZQ004)
文摘A new sesquiterpenoid, 1β,5α-guaiane-4β,10α-diol-6-one （1）, was isolated from 70% EtOH extract of the rhizomes of Acorus calamus. The structure was determined on spectroscopic methods, especially 2D NMR techniques. The absolute configuration of 1 was confirmed by TDDFT quantum chemical calculation of its ECD spectrum. Compound 1 showed promising anti-diabetic activity on a insulin-mediated glucose consumption model of HepG2 cells.
