The time of birth is a critical determinant of perinatal and long-term outcomes,and even trans-generational effects.Preterm birth is still the leading cause of infant mortality and morbidity.Unfortunately,rates of pre...The time of birth is a critical determinant of perinatal and long-term outcomes,and even trans-generational effects.Preterm birth is still the leading cause of infant mortality and morbidity.Unfortunately,rates of preterm birth remain high worldwide.Preterm parturition is a complex syndrome,which can be induced by several factors such as infection,cervical pathology,uterine overdistension,progesterone deficiency,vascular alterations(utero-placental ischemia,decidual hemorrhage),maternal and fetal stress,allograft reaction,allergic phenomena,and probably other several unknown factors.The mechanisms responsible for early labor activation have been partially identified and involve receptors,chemokines,and inflammatory cytokines.It is very useful to understand the cellular and biochemical pathways responsible for preterm labor activation to identify,treat,and prevent negative outcome in a timely manner.Researchers and clinicians play a key role in improving biochemical knowledge on preterm delivery,identifying risk factors,and applying multilevel preventive strategies.展开更多
Breast neuroendocrine carcinoma is a rare entity.It constitutes less than 0.5%of breast malignancies,and is usually diagnosed in older women.The occurrence of this type in young patients during pregnancy is extremely ...Breast neuroendocrine carcinoma is a rare entity.It constitutes less than 0.5%of breast malignancies,and is usually diagnosed in older women.The occurrence of this type in young patients during pregnancy is extremely rare.Only 2 cases were previously reported.Both were diagnosed at earlier stage with the appearance of a palpable breast mass.Hereby,we present the case of a young patient at 28 weeks’gestation admitted for severe diffuse back pain and neurologic deficit due to spinal cord compression at the level of C5 vertebra,and nerve root compression at the level of L5 vertebrae.To the best of our knowledge,this is the first case of oncologic emergency during pregnancy due to a metastatic poorly differentiated breast carcinoma with neuroendocrine differentiation in the absence of a detectable primary focus of malignancy in the breast.We also discuss the management and the obstetrical outcome of this patient.展开更多
文摘The time of birth is a critical determinant of perinatal and long-term outcomes,and even trans-generational effects.Preterm birth is still the leading cause of infant mortality and morbidity.Unfortunately,rates of preterm birth remain high worldwide.Preterm parturition is a complex syndrome,which can be induced by several factors such as infection,cervical pathology,uterine overdistension,progesterone deficiency,vascular alterations(utero-placental ischemia,decidual hemorrhage),maternal and fetal stress,allograft reaction,allergic phenomena,and probably other several unknown factors.The mechanisms responsible for early labor activation have been partially identified and involve receptors,chemokines,and inflammatory cytokines.It is very useful to understand the cellular and biochemical pathways responsible for preterm labor activation to identify,treat,and prevent negative outcome in a timely manner.Researchers and clinicians play a key role in improving biochemical knowledge on preterm delivery,identifying risk factors,and applying multilevel preventive strategies.
文摘Breast neuroendocrine carcinoma is a rare entity.It constitutes less than 0.5%of breast malignancies,and is usually diagnosed in older women.The occurrence of this type in young patients during pregnancy is extremely rare.Only 2 cases were previously reported.Both were diagnosed at earlier stage with the appearance of a palpable breast mass.Hereby,we present the case of a young patient at 28 weeks’gestation admitted for severe diffuse back pain and neurologic deficit due to spinal cord compression at the level of C5 vertebra,and nerve root compression at the level of L5 vertebrae.To the best of our knowledge,this is the first case of oncologic emergency during pregnancy due to a metastatic poorly differentiated breast carcinoma with neuroendocrine differentiation in the absence of a detectable primary focus of malignancy in the breast.We also discuss the management and the obstetrical outcome of this patient.
