We sought to investigate the effects of 2 different coronary drug- eluting stents on the distribution of central or effector memory T cells circulating in the coronary sinus of patients with coronary artery disease wh...We sought to investigate the effects of 2 different coronary drug- eluting stents on the distribution of central or effector memory T cells circulating in the coronary sinus of patients with coronary artery disease who underwent percutaneous coronary revascularization. We randomly assigned 43 patients(mean age 65.4± 4.3 years; 34 men) presenting with stable coronary disease and angiographically proved stenosis of the left anterior descending artery to treatment with sirolimus- or paclitaxel- eluting stents. Heparinized blood samples were obtained from the coronary sinus before and 20 minutes after stent implantation. Analysis of surface phenotype was performed by 4- color flow cytometry, and data are expressed as the percentage of positive cells. The percentages of CD8+ and CD4+ effector memory T cells, as defined by the CD3+ CD45RO+ CD27- phenotype, were significantly reduced in patients who received a sirolimus- eluting stent compared with the basal values. Conversely, the percentages of CD8+ , but not CD4+ , central memory T cells(CD3+ CD45RO+ CD27+ ) were increased in the same treatment group after the revascularization procedure. No changes in the percentages of memory T- cell populations in the paclitaxel- eluting stent group were observed. These findings show that sirolimus- eluting stents rapidly induced a redistribution of memory T lymphocytes, with a significant decrease of proinflammatory effector memory T cells circulating within the coronary sinus.展开更多
文摘We sought to investigate the effects of 2 different coronary drug- eluting stents on the distribution of central or effector memory T cells circulating in the coronary sinus of patients with coronary artery disease who underwent percutaneous coronary revascularization. We randomly assigned 43 patients(mean age 65.4± 4.3 years; 34 men) presenting with stable coronary disease and angiographically proved stenosis of the left anterior descending artery to treatment with sirolimus- or paclitaxel- eluting stents. Heparinized blood samples were obtained from the coronary sinus before and 20 minutes after stent implantation. Analysis of surface phenotype was performed by 4- color flow cytometry, and data are expressed as the percentage of positive cells. The percentages of CD8+ and CD4+ effector memory T cells, as defined by the CD3+ CD45RO+ CD27- phenotype, were significantly reduced in patients who received a sirolimus- eluting stent compared with the basal values. Conversely, the percentages of CD8+ , but not CD4+ , central memory T cells(CD3+ CD45RO+ CD27+ ) were increased in the same treatment group after the revascularization procedure. No changes in the percentages of memory T- cell populations in the paclitaxel- eluting stent group were observed. These findings show that sirolimus- eluting stents rapidly induced a redistribution of memory T lymphocytes, with a significant decrease of proinflammatory effector memory T cells circulating within the coronary sinus.
