Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease

Background Triglyceride glucose (TyG) index is a novel marker for metabolic disorders, and recently it has been reported to be associated with cardiovascular disease (CVD) risk in apparently healthy individuals.However the prognostic value of TyG index in patients with stable coronary artery disease (CAD) is not determined.

Clinical,biochemical and genetic characteristics of familial hypercholesterolemia with and without type 2 diabetes

Background Though type 2 diabetes mellitus(T2DM)is an important and independent risk factor for coronary artery disease(CAD)in general population,whether this feature also exists in patients with familial hypercholesterolemia(FH)is less determined.The current study aims to characterize the clinical,laboratory,coronary and genetic characteristics of the FH patients with T2DM compared with FH alone.

The different relations of PCSK9 and Lp(a) to the presence and severity of atherosclerotic lesions in patients with HeFH

Background Relations of lipoprotein (a)(Lp[a]) and proprotein convertase substilisin/kexin type 9 (PCSK9) levels to coronary artery disease (CAD) have been well established in general population, while little is known about the association between Lp(a) or PCSK9 and atherosclerotic lesions of different artery sites in patients with familial hypercholesterolemia (FH).

Professor Ruixia Pei's Experience in Treating Hyperthyroidism

In this article,we summarize the clinical experience ofProfessor Ruixia Pei,a famous traditional Chinese medicine practitioner in Shaanxi Province,China,in treating hyperthyroidism.The etiology and pathogenesis,syndrome differentiation,and medication experience are introduced in detail.This paper summarizes the advantages of Professor Pei's methods of syndrome differentiation and treatment of hyperthyroidism.This may help enrich the clinical treatment of hyperthyroidism,and provide some diagnosis and treatment ideas.

Ruixia Pefs Experience in the Treatment of Hypothyroidism

This study is to summarize Professor Pei's experience in treating hypothyroidism.Professor Pei has been engaged in clinical endocrinology for more than 30 years and has unique insights into hypothyroidism.She believes that the disease is caused by liver depression,phlegm binding,yin deficiency,and fire effulgence.The basic principles of treatment are regulating Qi movement and harmonizing viscera.During treatment,the emphasis is on the influence of emotions on the disease.Both the liver and spleen should be given equal attention and the medication should be mild with balanced cold and heat.

Single-cell RNA sequencing in cornea research:Insights into limbal stem cells and their niche regulation

The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye,which acts as a protective barrier and is critical for clear and stable vision.Its continuous renewal or wound healing depends on the proliferation and differentiation of limbal stem cells(LSCs),a cell population that resides at the limbus in a highly regulated niche.Dysfunction of LSCs or their niche can cause limbal stem cell deficiency,a disease that is manifested by failed epithelial wound healing or even blindness.Nevertheless,compared to stem cells in other tissues,little is known about the LSCs and their niche.With the advent of single-cell RNA sequencing,our understanding of LSC characteristics and their microenvironment has grown considerably.In this review,we summarized the current findings from single-cell studies in the field of cornea research and focused on important advancements driven by this technology,including the heterogeneity of the LSC population,novel LSC markers and regulation of the LSC niche,which will provide a reference for clinical issues such as corneal epithelial wound healing,ocular surface reconstruction and interventions for related diseases.

Analysis on Operational Safety and Efficiency of FAO System in Urban Rail Transit

This paper discusses two urgent problems that need to be solved in fully automatic operation(FAO)for urban rail transit.The first is the analysis of safety in FAO,while another is the analysis of efficiency in FAO.Firstly,this paper establishes an operational safety evaluation index system from the perspective of operation for the unique or typical risk sources of the FAO system,and uses the analytic hierarchy process(AHP)to evaluate the indicators,analyzes various factors that affect the safe operation of FAO,and provides safety management recommendations for FAO lines operation to maintain the FAO system specifically.Secondly,taking the Yanfang Line as an example,this paper uses OpenTrack software to analyze the efficiency of FAO operation,and conducts simulation calculations for key links such as the mainline tracking interval,train entry and exit,and return limit interval.The fault impact surface of the FAO trains is simulated and discussed to verify whether FAO can meet the long-term operation requirements of Yanfang Line.Finally,this paper compares the simulation data of FAO on the Yanfang Line with manual operation(MO)to verify the advantages of FAO and guide the engineering construction of subsequent fully automated driving lines.

Efficacy of image-enhanced endoscopy for colorectal adenoma detection:A multicenter,randomized trial

BACKGROUND Improved adenoma detection at colonoscopy has decreased the risk of developing colorectal cancer.However,whether image-enhanced endoscopy(IEE)further improves the adenoma detection rate(ADR)is controversial.AIM To compare IEE with white-light imaging(WLI)endoscopy for the detection and identification of colorectal adenoma.METHODS This was a multicenter,randomized,controlled trial.Participants were enrolled between September 2019 to April 2021 from 4 hospital in China.Patients were randomly assigned to an IEE group with WLI on entry and IEE on withdrawal(n=2113)or a WLI group with WLI on both entry and withdrawal(n=2098).The primary outcome was the ADR.The secondary endpoints were the polyp detection rate(PDR),adenomas per colonoscopy,adenomas per positive colonoscopy,and factors related to adenoma detection.RESULTS A total of 4211 patients(966 adenomas)were included in the analysis(mean age,56.7 years,47.1%male).There were 2113 patients(508 adenomas)in the IEE group and 2098 patients(458 adenomas)in the WLI group.The ADR in two group were not significantly different[24.0%vs 21.8%,1.10,95%confidence interval(CI):0.99-1.23,P=0.09].The PDR was higher with IEE group(41.7%)than with WLI group(36.1%,1.16,95%CI:1.07-1.25,P=0.01).Differences in mean withdrawal time(7.90±3.42 min vs 7.85±3.47 min,P=0.30)and adenomas per colonoscopy(0.33±0.68 vs 0.28±0.62,P=0.06)were not significant.Subgroup analysis found that with narrowband imaging(NBI),between-group differences in the ADR,were not significant(23.7%vs 21.8%,1.09,95%CI:0.97-1.22,P=0.15),but were greater with linked color imaging(30.9%vs 21.8%,1.42,95%CI:1.04-1.93,P=0.04).the second-generation NBI(2G-NBI)had an advantage of ADR than both WLI and the first-generation NBI(27.0%vs 21.8%,P=0.01;27.0%vs 21.2.0%,P=0.01).CONCLUSION This prospective study confirmed that,among Chinese,IEE didn’t increase the ADR compared with WLI,but 2G-NBI increase the ADR.

非肥胖型糖尿病小鼠唾液流率、颌下腺造影及病理研究

目的 :研究非肥胖型糖尿病小鼠 (nonobesediabeticmouse ,NOD)唾液总流率 ;颌下腺造影及病理表现。材料及方法 :本研究将 5 6只NOD小鼠分 9周、16周、2 0周及 2 4周 4个不同年龄组测定其唾液总流率 ,颌下腺造影及颌下腺病理学研究 ,用 32只Balb/c小鼠分同样年龄组进行对照。结果 :NOD小鼠唾液总流率随年龄增大而下降 ,Balb/c小鼠则变化不大。 2 0周以后NOD小鼠颌下腺造影有造影剂外溢 ,排空功能明显迟缓。 9周NOD小鼠颌下腺见淋巴细胞浸润 ,随年龄增长 ,淋巴细胞浸润加重。结论 :NOD小鼠涎腺的形态及功能均明显受累 ,与人类SS表现类似。

创始人专业背景与企业创新绩效:基于医药生物行业的实证研究

本文以医药生物行业A股民营上市公司为样本,对企业创始人的专业背景如何影响企业创新绩效进行了实证研究。结果表明,在医药生物行业中,创始人具有该领域相关专业背景能够正向促进企业创新。此外,企业的核心价值观在其中发挥了中介效应;国家实施创新政策具有调节效应,有利于加强创始人专业背景对企业创新的促进作用。进一步研究发现,具有专业背景的创始人通过增加研发投入强度和再聘请具有该领域专业背景高管的途径促进了企业创新。本文的研究结论对推动专业人才在"双创"背景下积极创业、创新,以不断提高我国创新水平具有重要的启示意义。

一例新型二钴取代锑钨酸盐:合成、表征及光催化水氧化性能（英文）

太阳能分解水制氢作为解决当前能源危机和环境危机最理想和最有前途的策略之一正受到越来越多的关注.在人工模拟光合作用过程中,水的氧化(2H_2O→4H^++O_2+4e^-)是整个反应过程的瓶颈,因此开发高效稳定水氧化催化剂是提高人工光合作用性能的关键.在过去的几十年里,全世界科研工作者已经为设计合成高效稳定的均相和多相水氧化催化剂做了大量工作.在均相水氧化领域,多金属氧酸盐(简称多酸)作为一类结构多样的多金属氧簇化合物,由于其良好的氧化、热、水解稳定性,能够在不改变结构的前提下进行快速、可逆、多电子转移反应,因而受到广泛关注.2009年, Hill课题组首次将四钌多酸用于光驱动水氧化体系.随后,他们报道了不含贵金属的四钴多酸(Co_4(H_2O)_2(PW_9O_(34))_2]^(10-)催化水氧化的工作.王恩波团队和我们课题组在该领域也进行了一些深入研究.值得注意的是,由于Sb3+易于在水溶液中水解,这在很大程度上阻碍了锑钨酸盐前驱体与过渡金属离子结合形成多酸簇,所以导致有关过渡金属取代钨锑酸盐的报道非常少.本文采用一锅自组装策略,利用缺位多酸前驱体[B-α-SbW_9O_(33)]^(9-)与Co_(2+)在弱酸性条件下反应,首次合成出一个结构新颖的夹心型锑钨酸盐Na_4[Co_2(H_2O)_6Sb_2(H_2O)_4 (B-β-SbW_9O_(33))_2]?39H_2O(1).在可见光照射下,可有效催化水氧化反应,在最佳反应条件(Na_2S_2O_8为牺牲电子受体,[Ru(bpy)_3]Cl_2为光敏剂,缓冲溶液pH=8.5)下,反应的转化数和氧气收率最高分别可达193和30.8%,初始量子效率和初始转化频率分别为36.2%和5.3 s–1.紫外-可见吸收光谱、反应前后催化剂的红外光谱、毛细管电泳及甲苯萃取等实验结果表明,该锑钨酸盐1是一个稳定的光催化水氧化催化剂.

Optimization Scheme of Large Passenger Flow in Huoying Station,Line 13 of Beijing Subway System

This paper focuses on the distribution of passenger flow in Huoying Station,Line 13 of Beijing subway system.The transformation measures taken by Line 13 since operation are firstly summarized.Then the authors elaborate the facilities and equipment of this station,especially the node layout and passenger flow field.An optimization scheme is proposed to rapidly distribute the passenger flow in Huoying Station by adjusting the operation time of the escalator in the direction of Xizhimen.The authors adopt Queuing theory and Anylogic simulation software to simulate the original and the optimized schemes of Huoying Station to distribute the passenger flow.The results of the simulation indicate that the optimized scheme could effectively alleviate the traffic congestion in the hall of Huoying Station,and the pedestrian density in other places of the hall is lowered;passengers could move freely in the hall and no new congestion points would form.The rationality of the scheme is thus proved.

基于原子/分子团簇结构的材料与器件制造

原子/分子团簇是物质结构的一种新形态,具有独特的本征性质。从原子/分子团簇到器件的跨尺度制造,将为国防高端装备和新兴电子等产业发展带来深刻变革。团簇的多物质构效关系、宏量制造、团簇结构跨尺度构筑以及团簇器件的高性能制造等是原子/分子团簇器件制造的关键发展方向,主导着从原子到产品制造的发展历程。把握这些发展背后的重要机遇,将有助于占领原子级制造研究的制高点,引领原子级制造方法的变革。本文从团簇新材料的宏量制造、新型功能器件的原子/分子团簇构筑、团簇—器件的跨尺度制造工艺和装备等三个方面概括了原子/分子团簇与器件制造领域的主要研究进展,总结了原子/分子团簇与器件领域的关键科学问题及面临的挑战,并对其未来发展方向和发展战略给出了建议。

基于XML的油气管道设备模型交互标准化方法

油气管道SCADA系统中设备模型的规范化和科学化,是保障油气管道SCADA系统中设备的统一和精准性的基础。本文分析了现有系统设备模型交互中存在的问题;基于国产油气管道SCADA系统,设计了包括公共模型层、子模型层和设备模型层的三级设备模型结构;采用基于XML标准的模型文件,提出了进行设备模型数据交互的架构。该三级设备模型在公司自主研发的油气管道SCADA系统软件—管道控制系统(PCS)软件中已得到实际应用,实践证明:显著减少了新增管道建模工作量,保证了系统中设备模型的安全性和一致性。

Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells(CAR-T) immunotherapy: a systematic review of case reports

Objective: Cytokine release syndrome (CRS) and tumor lysis syndrome (TLS) that occur after chimeric antigen receptor T (CAR-T) cells are reinfused, which severely affect the survival and prognosis of patients. Although several articles have reported on the care of CAR-T cell immunotherapy, the quality of the study and the effectiveness of holistic nursing interventions have not been systematically reviewed. The purpose of this study was to systematically evaluate the existing holistic nursing interventions of CAR-T cell immunotherapy. Methods: A literature search for keywords was performed in PubMed, EMBASE, the Cochrane Library, CNKI, CBM, and Wanfang Data from its inception until January 2018. Studies were deemed eligible if they comprised patients with tumor receiving CAR-T cell immunotherapy, described the holistic nursing process, and were published in Chinese and English. Results: A total of 6 articles on holistic nursing interventions of CAR-T cell immunotherapy are reported, and the nursing methods and results of each article are analyzed. The quality of the studies included was medium. All nursing measures were considered effective. Conclusions: Holistic nursing programs reduce the incidence of CRS and TLS and improve the quality of life of cancer patients.

A systematic review of the treatment of lower eyelid retraction and our attempt of a dermal-orbicularis oculi suspension flap

Lower eyelid retraction describes the inferior displacement of the lower eyelid with or without inversion or ectropion.Based on the causes of lower eyelid retraction,we divided the forming factors of lower eyelid retraction into three categories:(1)change in the balance of forces associated with the lower eyelid margin;(2)excessive loss of lower eyelid volume;(3)changes in the relative position of the eyeball and lower lid margin.In this review,the corresponding treatment methods are elaborated on individually for the above three forming factors.We also reported,for the first time,a new treatment for lower eyelid retraction.We created a dermal-orbicularis oculi suspension flap on the lateral side of the canthus and suspended it upward and inward on the dense connective tissue over the lateral bony surface of the orbital rim.The longest follow-up time was one year,and the results were satisfactory.

Professor Ruixia Pei's Clinical Experience in Treating Globus Hystericus with"Harmonizing Method"

To summarize professor Pei9s experience in treating globus hystericus.Methods:Learn from your teacher.Results:Professor Pei had been suffering from the disease for more than 30 years and had her unique views on the treatment of globus hystericus,which are mostly for emotional dysfunction,liver Qi is not comfortable,functioning of Qi is not adjusted,Yin and Yang imbalance.The basic principle of treatment is to grasp the core pathogenesis,take harmony as the method and balance as the duration,harmonize Qi,regulate Yin and Yang,use drugs to disperse the liver and rectify Qi,as well as auxiliary treatment with products to promote blood circulation,remove blood stasis,dryness and dampness,and clear heat.

Risk stratification for radioactive iodine refractoriness using molecular alterations in distant metastatic differentiated thyroid cancer

Objective: Patients with radioactive iodine-refractory differentiated thyroid cancer(RAIR-DTC) are often diagnosed with delay and constrained to limited treatment options. The correlation between RAI refractoriness and the underlying genetic characteristics has not been extensively studied.Methods: Adult patients with distant metastatic DTC were enrolled and assigned to undergo next-generation sequencing of a customized 26-gene panel(Thyro Lead). Patients were classified into RAIR-DTC or non-RAIR groups to determine the differences in clinicopathological and molecular characteristics. Molecular risk stratification(MRS) was constructed based on the association between molecular alterations identified and RAI refractoriness, and the results were classified as high, intermediate or low MRS.Results: A total of 220 patients with distant metastases were included, 63.2% of whom were identified as RAIRDTC. Genetic alterations were identified in 90% of all the patients, with BRAF(59.7% vs. 17.3%), TERT promoter(43.9% vs. 7.4%), and TP53 mutations(11.5% vs. 3.7%) being more prevalent in the RAIR-DTC group than in the non-RAIR group, except for RET fusions(15.8% vs. 39.5%), which had the opposite pattern. BRAF and TERT promoter are independent predictors of RAIR-DTC, accounting for 67.6% of patients with RAIR-DTC. MRS was strongly associated with RAI refractoriness(P<0.001), with an odds ratio(OR) of high to low MRS of 7.52 [95%confidence interval(95% CI), 3.96-14.28;P<0.001] and an OR of intermediate to low MRS of 3.20(95% CI,1.01-10.14;P=0.041).Conclusions: Molecular alterations were associated with RAI refractoriness, with BRAF and TERT promoter mutations being the predominant contributors, followed by TP53 and DICER1 mutations. MRS might serve as a valuable tool for both prognosticating clinical outcomes and directing precision-based therapeutic interventions.

The global regulation of c-di-GMP and cAMP in bacteria

Nucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria.The best-studied examples are cyclic AMP(cAMP)and bis-(3'-5')-cyclic dimeric guanosine monophosphate(c-di-GMP),which both act as global regulators.Global regulatory frameworks of c-di-GMP and cAMP in bacteria show several parallels but also significant variances.In this review,we llustrate the global regulatory models of the two nucleotide second messengers,compare the different regulatory frameworks between c-di-GMP and cAMP,and discuss the mechanisms and physiological significance of cross-regulation between c-di-GMP and cAMP.c-di-GMP responds to numerous signals de-pendent on a great number of metabolic enzymes,and it regulates various signal transduction pathways through its huge number of effectors with varying activities.In contrast,due to the limited quantity,the cAMP metabolic enzymes and its major effector are regulated at different levels by diverse signals.cAMP performs its global regulatory function primarily by controlling the transcription of a large number of genes via cAMP receptor protein(CRP)in most bacteria.This review can help us understand how bacteria use the two typical nucleotide second messengers to effectively coordinate and integrate various physiological processes,providing theoretical guidelines for future research.

OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human health.Digging genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted environments.This study investigated a functionally uncharacterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of rice.OsPDR20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd stress.Ectopic expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd accumulation.Knockdown of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of grains.However,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and grain.These results suggest that OsPDR20 is actively involved in Cd accumulation and homeostasis in rice crops.The increased Cd accumulation in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.