Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implic...Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncR NAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncR NAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncR NAs in HCC are still deficient, an improved understanding of the roles played by lncR NAs in HCC will lead to a much more effective utilization of those lnc RNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.展开更多
The acetabular labrum is a triangular fibrocartilaginous structure that forms a horseshoe-shaped attachment to the acetabular rim, which connects the acetabulum to the underlying transverse acetabular ligament [Figure...The acetabular labrum is a triangular fibrocartilaginous structure that forms a horseshoe-shaped attachment to the acetabular rim, which connects the acetabulum to the underlying transverse acetabular ligament [Figure la].m Up to 90% of symptomatic patients with developmental dysplasia of the hip （DDH） are found to combine with lesions of acetabular labrum.展开更多
基金Supported by Partly Fund of Guangxi Provincial Health Bureau Scientific Research Project,No.Z2014054Youth Science Foun-dation of Guangxi Medical University,No.GXMUYSF201311+4 种基金Guangxi University Science and Technology Research Projects,No.LX2014075Natural Science Foundation of GuangxiNos.2015GXNSFBA139157,2015GXNSFCA139009National Natural Science Foundation of China,Nos.NSFC81360327,NSFC81560489NSFC81560469
文摘Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncR NAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncR NAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncR NAs in HCC are still deficient, an improved understanding of the roles played by lncR NAs in HCC will lead to a much more effective utilization of those lnc RNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.
文摘The acetabular labrum is a triangular fibrocartilaginous structure that forms a horseshoe-shaped attachment to the acetabular rim, which connects the acetabulum to the underlying transverse acetabular ligament [Figure la].m Up to 90% of symptomatic patients with developmental dysplasia of the hip （DDH） are found to combine with lesions of acetabular labrum.
