Objective The aim of this study was to identify clinicopathological factors predictive of lymph node metastasis (LNM) in intramucosal poorly differentiated early gastric cancer (EGC), and further to expand the possib...Objective The aim of this study was to identify clinicopathological factors predictive of lymph node metastasis (LNM) in intramucosal poorly differentiated early gastric cancer (EGC), and further to expand the possibility of using laparoscopic surgery for the treatment of intramucosal poorly differentiated EGC.展开更多
Objective： To study the expression of T-cell transcription factor-4 （Tcf-4） gene in human colorectal cancer （CRC） and the relationship between Tcf-4 gene and progression of CRC. Methods： Quantitative real time R...Objective： To study the expression of T-cell transcription factor-4 （Tcf-4） gene in human colorectal cancer （CRC） and the relationship between Tcf-4 gene and progression of CRC. Methods： Quantitative real time RT-PCR was used to de- tect the expression of Tcf-4 mRNA in 31 CRC and para-cancerous tissues. The correlation of expression of the Tcf-4 gene with clinicopathologicel characteristics of CRC was also analyzed. Results： Compared with normal tissues, up-regulation of Tcf4 mRNAwas observed in 31 CRC tissues （t = 2.188, P = 0.037）. The expression values of Tcf-4 mRNA in Dukes A, B, C and D were 8.38 ＋ 1.92, 6.93 ＋ 1.44, 6.00 ＋ 1.26 and 3.50 ＋ 0.71 respectively. Analyzed by one-way ANOVA, there were significant differences in the expressions of Tcf-4 in different Dukes stages （F = 6.454, P = 0.002）. Moreover, the over-expression of Tcf-4 was significantly correlated with lymph node metastases. However the expression of Tcf-4 was no correlation with the age, gender of patients and cell differentiation of CRC in this study. Conclusion： The higher expression level of Tcf-4 mRNA in CRC tissues suggested that the over-expression of Tcf-4 gene may be related to the development and invasion of CRC.展开更多
基金Supported by a grant from the Science Foundation of Xingtai City (No.20102025-2)
文摘Objective The aim of this study was to identify clinicopathological factors predictive of lymph node metastasis (LNM) in intramucosal poorly differentiated early gastric cancer (EGC), and further to expand the possibility of using laparoscopic surgery for the treatment of intramucosal poorly differentiated EGC.
文摘Objective： To study the expression of T-cell transcription factor-4 （Tcf-4） gene in human colorectal cancer （CRC） and the relationship between Tcf-4 gene and progression of CRC. Methods： Quantitative real time RT-PCR was used to de- tect the expression of Tcf-4 mRNA in 31 CRC and para-cancerous tissues. The correlation of expression of the Tcf-4 gene with clinicopathologicel characteristics of CRC was also analyzed. Results： Compared with normal tissues, up-regulation of Tcf4 mRNAwas observed in 31 CRC tissues （t = 2.188, P = 0.037）. The expression values of Tcf-4 mRNA in Dukes A, B, C and D were 8.38 ＋ 1.92, 6.93 ＋ 1.44, 6.00 ＋ 1.26 and 3.50 ＋ 0.71 respectively. Analyzed by one-way ANOVA, there were significant differences in the expressions of Tcf-4 in different Dukes stages （F = 6.454, P = 0.002）. Moreover, the over-expression of Tcf-4 was significantly correlated with lymph node metastases. However the expression of Tcf-4 was no correlation with the age, gender of patients and cell differentiation of CRC in this study. Conclusion： The higher expression level of Tcf-4 mRNA in CRC tissues suggested that the over-expression of Tcf-4 gene may be related to the development and invasion of CRC.
