Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated n...Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes - the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown.展开更多
基金supported by the Argentinean National Agency of Scientific and Technological Promotion(PICT 2015-1921)by the University of Buenos Aires(20020110100034)+1 种基金by the German Federal Ministry of Education and Research(BMBF)the German Research Foundation(DFG)
文摘Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes - the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain unknown.
