Chronic hyperglycemia statue noticed in diabetes mellitus favors the manifestation of oxidative stress by increasing the production of reactive oxygen species and/or by reducing the antioxidant defense system activity...Chronic hyperglycemia statue noticed in diabetes mellitus favors the manifestation of oxidative stress by increasing the production of reactive oxygen species and/or by reducing the antioxidant defense system activity.Zinc plays an important role in antioxidant defense in type2 diabetic patients by notably acting as a cofactor of the superoxide dismutase enzyme,by modulating the glutathione metabolism and metallothionein expression,by competing with iron and copper in the cell membrane and by inhibiting nicotinamide adenine dinucleotide phosphate-oxidase enzyme.Zinc also improves the oxidative stress in these patients by reducing chronic hyperglycemia.It indeed promotes phosphorylation of insulin receptors by enhancing transport of glucose into cells.However,several studies reveal changes in zinc metabolism in individuals with type 2 diabetes mellitus and controversies remain regarding the effect of zinc supplementation in the improvement of oxidative stress in these patients.Faced with the serious challenge of the metabolic disorders related to oxidative stress in diabetes along with the importance of antioxidant nutrients in the control of this disease,new studies may contribute to improve our understanding of the role played by zinc against oxidative stress and its connection with type 2 diabetes mellitus prognosis.This could serve as a prelude to the development of prevention strategies and treatment of disorders associated with this chronic disease.展开更多
We investigated the cardiovascular disease (CVD) risk of the elderly in a city in northeastern Brazil, and the correlation of this risk with vitamin D and PTH status. We studied 359 elderly, both genders, from Piau...We investigated the cardiovascular disease (CVD) risk of the elderly in a city in northeastern Brazil, and the correlation of this risk with vitamin D and PTH status. We studied 359 elderly, both genders, from Piauí-Teresina-Brazil. Variables investigated: body mass index, waist circumference, systolic and diastolic blood pressure. A subsample (n = 100) was investigated for biochemical analyses: PTH and 25(OH)-vitamin D levels;total, HDL and LDL-cholesterol;and fasting glucose. High blood pressure, abdominal obesity, sedentarism, high total cholesterol, high triacylglycerol levels, as well as low vitamin D levels, were, among the investigated variables, the most prevalent. Visceral adiposity and low vitamin D were found to be more prevalent in women than in men, whilst alcohol intake and smoking were more prevalent in men. The correlation between vitamin D, PTH and the investigated risk variables, under our study conditions, were not significant.展开更多
文摘Chronic hyperglycemia statue noticed in diabetes mellitus favors the manifestation of oxidative stress by increasing the production of reactive oxygen species and/or by reducing the antioxidant defense system activity.Zinc plays an important role in antioxidant defense in type2 diabetic patients by notably acting as a cofactor of the superoxide dismutase enzyme,by modulating the glutathione metabolism and metallothionein expression,by competing with iron and copper in the cell membrane and by inhibiting nicotinamide adenine dinucleotide phosphate-oxidase enzyme.Zinc also improves the oxidative stress in these patients by reducing chronic hyperglycemia.It indeed promotes phosphorylation of insulin receptors by enhancing transport of glucose into cells.However,several studies reveal changes in zinc metabolism in individuals with type 2 diabetes mellitus and controversies remain regarding the effect of zinc supplementation in the improvement of oxidative stress in these patients.Faced with the serious challenge of the metabolic disorders related to oxidative stress in diabetes along with the importance of antioxidant nutrients in the control of this disease,new studies may contribute to improve our understanding of the role played by zinc against oxidative stress and its connection with type 2 diabetes mellitus prognosis.This could serve as a prelude to the development of prevention strategies and treatment of disorders associated with this chronic disease.
文摘We investigated the cardiovascular disease (CVD) risk of the elderly in a city in northeastern Brazil, and the correlation of this risk with vitamin D and PTH status. We studied 359 elderly, both genders, from Piauí-Teresina-Brazil. Variables investigated: body mass index, waist circumference, systolic and diastolic blood pressure. A subsample (n = 100) was investigated for biochemical analyses: PTH and 25(OH)-vitamin D levels;total, HDL and LDL-cholesterol;and fasting glucose. High blood pressure, abdominal obesity, sedentarism, high total cholesterol, high triacylglycerol levels, as well as low vitamin D levels, were, among the investigated variables, the most prevalent. Visceral adiposity and low vitamin D were found to be more prevalent in women than in men, whilst alcohol intake and smoking were more prevalent in men. The correlation between vitamin D, PTH and the investigated risk variables, under our study conditions, were not significant.
