C-H bond can undergo vicarious Michael addition reaction （VMA） with doubleactivated double bond in the absence of strong base and catalyst under mild conditions. Intramolecular H-bonding, electron-withdrawing induct...C-H bond can undergo vicarious Michael addition reaction （VMA） with doubleactivated double bond in the absence of strong base and catalyst under mild conditions. Intramolecular H-bonding, electron-withdrawing inductive effect, and steric hindrance at aposition of nucleophile facilitates C-H addition over N-H addition. By using VMA, high branching multiplicity, novel branching pattern, controllable density and distribution of functional groups can be envisioned for novel dendrimer synthesis.展开更多
文摘C-H bond can undergo vicarious Michael addition reaction （VMA） with doubleactivated double bond in the absence of strong base and catalyst under mild conditions. Intramolecular H-bonding, electron-withdrawing inductive effect, and steric hindrance at aposition of nucleophile facilitates C-H addition over N-H addition. By using VMA, high branching multiplicity, novel branching pattern, controllable density and distribution of functional groups can be envisioned for novel dendrimer synthesis.
