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Modification of contact lenses via metal-organic frameworks for glaucoma treatment
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作者 Alexey V.Yaremenko Roman O.Melikov +19 位作者 Nadezhda A.Pechnikova Iaroslav B.Belyaev Alina Ringaci Tamara V.Yaremenko Aziz B.Mirkasymov Alexandr A.Tamgin Vladislav I.Rodionov Sofya M.Dolotova Grigory A.Plisko Evgeny D.Semivelichenko Anna S.Rogova Albert R.Muslimov Arina S.Ivkina dmitry yu.ivkin Valery P.Erichev Sergey M.Deyev Sergey E.Avetisov Yongjiang Li Hai-Jun Liu Ivan V.Zelepukin 《Aggregate》 EI CAS 2024年第5期358-370,共13页
The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure.Here,human contact lenses are modified with highly porous metal-organic frameworks with sustained release of brimonid... The prevention of blindness from glaucoma requires multiple treatments to lower intraocular pressure.Here,human contact lenses are modified with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma treatment.Various metal-organic frameworks were screened for their attachment to lenses,loading with brimonidine,and drug-release properties.Opti-mized therapeutic ocular lenses conjugated with MIL-101(Cr)frameworks maintain optical transparency and power.Coating of lenses with MIL-101(Cr)nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the cornea.The hybrid lenses provided a 4.5-fold better decrease in eye pressure,compared by area under the curve(AUC)value to a commercially available brimonidine tartrate solution.Therapeutic lenses did not induce any notable eye irritation or corneal damage in vivo.The newly devel-oped hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases. 展开更多
关键词 BRIMONIDINE contact lenses drug delivery GLAUCOMA intraocular pressure metal-organic frameworks NANOPARTICLES
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