Objective: To describe recognition (letter) acuity at age 10 years in eyes with and without retinal residua of retinopathy of prematurity (ROP). Design: Presence and severity of ROP residua were documented by a study ...Objective: To describe recognition (letter) acuity at age 10 years in eyes with and without retinal residua of retinopathy of prematurity (ROP). Design: Presence and severity of ROP residua were documented by a study ophthalmologist. Masked testers measured monocular recognition visual acuity (Early Treatment of Diabetic Retinopathy Study) when the children were 10 years old. Two hundred forty-seven of 255 surviving Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) randomized trial patients participated. A reference group of 102 of 104 Philadelphia-based CRYO-ROP study participants who did not develop ROP was also tested. Results: More severe retinal residua were associated with worse visual acuity,regardless of whether retinal ablation was performed to treat the severe acute-phase ROP. However,within each ROP residua category,there was a wide range of visual acuity results. Conclusions: This is the first report of the relation between visual acuity (Early Treatment of Diabetic Retinopathy Study charts) and structural abnormalities related to ROP in a large group of eyes that developed threshold ROP in the perinatal period. Visual deficits are greater in eyes with more severe retinal residua than in eyes with mild or no residua. However,severity of ROP residua does not predict the visual acuity of an individual eye because within a single residua category,acuity may range from near normal to blind.展开更多
Objective: To describe parental perspectives on health status and health- related quality of life (HRQL) at age 10 years in children with birth weights less than 1251 g who participated in the multicenter Cryotherapy ...Objective: To describe parental perspectives on health status and health- related quality of life (HRQL) at age 10 years in children with birth weights less than 1251 g who participated in the multicenter Cryotherapy for Retinopathy of Prematurity (CRYO- ROP) study. Methods: In 244 participants in the randomized CRYO- ROP trial and 102 CRYO- ROP participants who did not develop ROP, the Health Utilities Index (HUI)- system was used to characterize health status for the following 8 attributes: vision, hearing, speech, ambulation, dexterity, emotion, cognition, and pain. Using a utility formula, HRQL was determined for each child on a scale from 0.0 (dead) to 1.00 (perfect health). Results: The proportion of the ROPrandomized group with limitations in 4 attributes or more was 20.6% compared with 2.0% for the no- ROP group. Within the ROP- randomized group, the proportion of “ sighted” children with limitations in 4 attributes or more was 6.4% vs 46.5% in the “ blind/low vision” group. The median HRQL score for the ROP- randomized children was lower than for the no- ROP children (0.72 vs 0.97, P < .001); the median HRQL score for the sighted- randomized children was 0.87 vs 0.27 for the blind/low vision children (P < .001). Conclusions: Threshold ROP was associated with functional limitations in health attributes and reduction in HRQL scores at age 10 years. Furthermore, among children who developed threshold ROP, a greater reduction in HRQL scores was found among children with a poor visual outcome compared with those with better sight.展开更多
文摘Objective: To describe recognition (letter) acuity at age 10 years in eyes with and without retinal residua of retinopathy of prematurity (ROP). Design: Presence and severity of ROP residua were documented by a study ophthalmologist. Masked testers measured monocular recognition visual acuity (Early Treatment of Diabetic Retinopathy Study) when the children were 10 years old. Two hundred forty-seven of 255 surviving Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) randomized trial patients participated. A reference group of 102 of 104 Philadelphia-based CRYO-ROP study participants who did not develop ROP was also tested. Results: More severe retinal residua were associated with worse visual acuity,regardless of whether retinal ablation was performed to treat the severe acute-phase ROP. However,within each ROP residua category,there was a wide range of visual acuity results. Conclusions: This is the first report of the relation between visual acuity (Early Treatment of Diabetic Retinopathy Study charts) and structural abnormalities related to ROP in a large group of eyes that developed threshold ROP in the perinatal period. Visual deficits are greater in eyes with more severe retinal residua than in eyes with mild or no residua. However,severity of ROP residua does not predict the visual acuity of an individual eye because within a single residua category,acuity may range from near normal to blind.
文摘Objective: To describe parental perspectives on health status and health- related quality of life (HRQL) at age 10 years in children with birth weights less than 1251 g who participated in the multicenter Cryotherapy for Retinopathy of Prematurity (CRYO- ROP) study. Methods: In 244 participants in the randomized CRYO- ROP trial and 102 CRYO- ROP participants who did not develop ROP, the Health Utilities Index (HUI)- system was used to characterize health status for the following 8 attributes: vision, hearing, speech, ambulation, dexterity, emotion, cognition, and pain. Using a utility formula, HRQL was determined for each child on a scale from 0.0 (dead) to 1.00 (perfect health). Results: The proportion of the ROPrandomized group with limitations in 4 attributes or more was 20.6% compared with 2.0% for the no- ROP group. Within the ROP- randomized group, the proportion of “ sighted” children with limitations in 4 attributes or more was 6.4% vs 46.5% in the “ blind/low vision” group. The median HRQL score for the ROP- randomized children was lower than for the no- ROP children (0.72 vs 0.97, P < .001); the median HRQL score for the sighted- randomized children was 0.87 vs 0.27 for the blind/low vision children (P < .001). Conclusions: Threshold ROP was associated with functional limitations in health attributes and reduction in HRQL scores at age 10 years. Furthermore, among children who developed threshold ROP, a greater reduction in HRQL scores was found among children with a poor visual outcome compared with those with better sight.
