Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate w...Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescencewas observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.展开更多
Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematologi...Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematological malignancies. Tw o cases of mantle cell lymphoma (MCL), one associated with an insect bite-like reaction and the other with a true hypersensitivity to mosquito bites, have pre viously been reported in the English language literature. The pathogenesis of th e skin eruption may be related to the release of different cytokines that also t rigger an IgE elevation and dermal eosinophils. Case report. We describe two add itional cases of MCL associated with an insect bite-like reaction. One patient had been diagnosed with MCL 4.5 years prior to the appearance of the skin erupt ion, and in the other patient the skin symptoms preceded the diagnosis of the MC L by 2 years and led to its diagnosis. Conclusions. Insect bite-like reaction may appear in patients with MCL. It is important to recognize this entity becaus e it may be the presenting sign of MCL.展开更多
文摘Background: Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective: To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods: Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results: A yellow-green fluorescencewas observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline-induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion: Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation.
文摘Background. An insect bite-like reaction and exaggerated reactions to insec t bites are nonspecific phenomena described primarily in association with chroni c lymphocytic leukemia (CLL), but also with other hematological malignancies. Tw o cases of mantle cell lymphoma (MCL), one associated with an insect bite-like reaction and the other with a true hypersensitivity to mosquito bites, have pre viously been reported in the English language literature. The pathogenesis of th e skin eruption may be related to the release of different cytokines that also t rigger an IgE elevation and dermal eosinophils. Case report. We describe two add itional cases of MCL associated with an insect bite-like reaction. One patient had been diagnosed with MCL 4.5 years prior to the appearance of the skin erupt ion, and in the other patient the skin symptoms preceded the diagnosis of the MC L by 2 years and led to its diagnosis. Conclusions. Insect bite-like reaction may appear in patients with MCL. It is important to recognize this entity becaus e it may be the presenting sign of MCL.