Dear Editor,SARS-CoV-2 is the etiological cause of COVID-19.RIG-I-like receptor(RLR)signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN,1 a major antiviral pathway.IFN deficiency2,3 was identified ...Dear Editor,SARS-CoV-2 is the etiological cause of COVID-19.RIG-I-like receptor(RLR)signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN,1 a major antiviral pathway.IFN deficiency2,3 was identified to be a significant risk factor of severe COVID-19,highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19.展开更多
基金supported partly by NIH grants:AI139439,AI149754,ES027013,ES028889 to YCsupported by NIH grants:AI161845,AI131669,AI140406,AI141178,and AI140726supported by a NIEHS training grant ES025494 (YC).
文摘Dear Editor,SARS-CoV-2 is the etiological cause of COVID-19.RIG-I-like receptor(RLR)signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN,1 a major antiviral pathway.IFN deficiency2,3 was identified to be a significant risk factor of severe COVID-19,highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19.
