The proinflammatory cytokine interleukin-1 has been implicated in host suscep tibility to Helicobacter pylori -associated disease. Recent studies suggest tha t this susceptibility may be under genetic control. It rema...The proinflammatory cytokine interleukin-1 has been implicated in host suscep tibility to Helicobacter pylori -associated disease. Recent studies suggest tha t this susceptibility may be under genetic control. It remains to be determined whether the relationship between IL-1 gene polymorphism and gastrointestinal di sease in patients with H. pylori infection is due to the role of IL-1 in determ ining susceptibility to H. pylori infection per se or to the development of dist inct pathological lesions. The aim of this study was to prospectively investigat e the relationship between selected polymorphisms in three of the major IL-1 ge ne family members, seeking associations with H. pylori infection and/or gastric cancer. A total of 559 individuals were studied: 191 patients attending for gast roscopy, 98 with current or previous H. pylori, an additional 79 patients with g astric cancer, and 289 healthy controls. The major novel finding of the study wa s a marked difference in the genotype frequencies for the IL1R1 HinfI SNP in tho se with current or previous evidence of H. pylori compared to those without. (GG , 53 vs 75%; GA, 40 vs 19%; AA, 7 vs 6%; P = 0.0079). The association indicat es an increased risk of H. pylori infection or persistence in those with the IL1 R1 Hinf1 A allele (0.27 vs 0.156; P = 0.009; OR = 2.01). Our results suggest tha t the relationship among IL-1 gene polymorphism, H. pylori, and disease is more complex than initially proposed. More detailed studies of the IL-1 gene cluste r are needed.展开更多
Our aims were to determine the frequency of antibodies to Saccharomyces cerevisiae in autoimmune hepatitis and assess associations with concurrent mucosal diseases, genetic factors,and corticosteroid response. Seropos...Our aims were to determine the frequency of antibodies to Saccharomyces cerevisiae in autoimmune hepatitis and assess associations with concurrent mucosal diseases, genetic factors,and corticosteroid response. Seropositivity was determined by enzyme immunoassay in 385 samples obtained from 178 patients.Antibodies to Saccharomyces cerevisiae were detected in 49 patients (28% ), and serum levels of immunoglobulin A were higher in seropositive patients (410 ± 35 versus 321 ± 20 mg/dL; P=0.02). Individuals with and without antibodies were not otherwise distinguished by concurrent mucosal diseases, laboratory findings, or outcomes. Antibodies to tissue transglutaminase occurred more commonly in seropositive patients (16 versus 4% ; P=0.008), but this association was lost when corroborating serological criteria for celiac disease were sought. We conclude that antibodies to Saccharomyces cerevisiae are common in autoimmune hepatitis. They may be associated with non-disease-specific immune responses, but they do not define individuals with a distinctive clinical phenotype,associated mucosal diseases, or treatment outcome.展开更多
文摘The proinflammatory cytokine interleukin-1 has been implicated in host suscep tibility to Helicobacter pylori -associated disease. Recent studies suggest tha t this susceptibility may be under genetic control. It remains to be determined whether the relationship between IL-1 gene polymorphism and gastrointestinal di sease in patients with H. pylori infection is due to the role of IL-1 in determ ining susceptibility to H. pylori infection per se or to the development of dist inct pathological lesions. The aim of this study was to prospectively investigat e the relationship between selected polymorphisms in three of the major IL-1 ge ne family members, seeking associations with H. pylori infection and/or gastric cancer. A total of 559 individuals were studied: 191 patients attending for gast roscopy, 98 with current or previous H. pylori, an additional 79 patients with g astric cancer, and 289 healthy controls. The major novel finding of the study wa s a marked difference in the genotype frequencies for the IL1R1 HinfI SNP in tho se with current or previous evidence of H. pylori compared to those without. (GG , 53 vs 75%; GA, 40 vs 19%; AA, 7 vs 6%; P = 0.0079). The association indicat es an increased risk of H. pylori infection or persistence in those with the IL1 R1 Hinf1 A allele (0.27 vs 0.156; P = 0.009; OR = 2.01). Our results suggest tha t the relationship among IL-1 gene polymorphism, H. pylori, and disease is more complex than initially proposed. More detailed studies of the IL-1 gene cluste r are needed.
文摘Our aims were to determine the frequency of antibodies to Saccharomyces cerevisiae in autoimmune hepatitis and assess associations with concurrent mucosal diseases, genetic factors,and corticosteroid response. Seropositivity was determined by enzyme immunoassay in 385 samples obtained from 178 patients.Antibodies to Saccharomyces cerevisiae were detected in 49 patients (28% ), and serum levels of immunoglobulin A were higher in seropositive patients (410 ± 35 versus 321 ± 20 mg/dL; P=0.02). Individuals with and without antibodies were not otherwise distinguished by concurrent mucosal diseases, laboratory findings, or outcomes. Antibodies to tissue transglutaminase occurred more commonly in seropositive patients (16 versus 4% ; P=0.008), but this association was lost when corroborating serological criteria for celiac disease were sought. We conclude that antibodies to Saccharomyces cerevisiae are common in autoimmune hepatitis. They may be associated with non-disease-specific immune responses, but they do not define individuals with a distinctive clinical phenotype,associated mucosal diseases, or treatment outcome.
