可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度

滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加（主动脉中活性氧水平同时升高）,这种现象类似于人类高血压中观察到的现象。

Performance of Sacrificial Anodes in Reinforced Concrete

The electrochemical performance of the anodes was measured in the reinforced concrete test block in artificial sea water. Their chemical composition,metallographic structure and surface morphology were analyzed. It was found that concrete mix proportion and the covering layer thickness had an impact on the performance of sacrificial anodes. The thermal-sprayed zinc alloy anodes had a more negative corrosion potential and larger galvanic current than metallurgy ones in the same conditions. They had similar chemical composition. But metallographic structure showed that the structure of thermal-sprayed zinc alloy anodes was a loose porous. This structure had the catalytic effect on the andes electrochemical reactions and made the anodes the electrochemical exchange current density increase and the corrosion potential move to negative direction.

外周血微生物与高血压风险的关系

虽然先前的研究报道表明肠道微生物组与高血压的发展密切相关,但血液微生物组的变化是否与高血压风险相关仍不清楚。方法:该巢式病例对照研究纳入150例高血压患者(高血压组)和150名年龄(±2岁)和性别(1∶1)相匹配的非高血压对象(对照组),对照组均来自“135”前瞻性队列研究。应用细菌16S核糖体RNA基因测序确定血液微生物组分。

瘢痕整复中皮肤软组织扩张器埋置部位感染的危险因素:2374例连续病例的回顾性研究

皮肤软组织扩张术是整形与烧伤外科常用的修复重建手术,对大面积体表瘢痕有良好的美学整复效果。然而,在组织扩张过程中,一旦出现并发症,不仅达不到原本的治疗目的,还可能会给患者带来新的损伤与瘢痕。皮肤软组织扩张器(以下简称扩张器)埋置部位感染是皮肤软组织扩张术的主要并发症。既往研究曾报道,使用组织扩张术进行瘢痕整复的患者扩张器埋置部位感染率为1.4%~35.4%。既往研究对感染的危险因素进行了一定研究,但多为小样本研究,且研究结论并不统一;仅有的一些大样本研究多集中在采用扩张术行乳房再造的并发症风险方面,适应证并非瘢痕整复。