Background Accumulating evidence indicates that systemic inflammation response is associated with the prognosis of various cancers. The aim of this study was to investigate the neutrophil-lymphocyte ratio （NLR）, whi...Background Accumulating evidence indicates that systemic inflammation response is associated with the prognosis of various cancers. The aim of this study was to investigate the neutrophil-lymphocyte ratio （NLR）, which is one of the systemic inflammation markers, in the prognosis of hepatocellular carcinoma （HCC） after treatment of transcatheter arterial chemoembolization （TACE）. Methods The clinical data of 178 HCC patients who received TACE were retrospectively analyzed. The optimal NLR cutoff was determined according to the receiver operating characteristic （ROC） analysis. All patients were divided into NLR-normal group and NLR-elevated group according to the cutoff, and the clinical features of these two groups were comparatively analyzed. Meanwhile, the overall survival and disease free survival （DFS） were analyzed using the Kaplan- Meier method. The risk factors of postoperative survival were investigated using univariate and multivariate Cox regression analyses. Results The optimal NLR cutoff was defined at 1.85 and 42 （23.6%） patients had an elevated NLR （NLR〉1.85）. The median survival time was 9.5 months （range 1-99 months）. The clinical data between the two groups were comparable, except for a-fetoprotein. Follow-up results showed that the median survival of patients with normal NLR was 17.5 months （range： 1-99 months） compared with 8 months （range： 8-68 months） of patients with elevated NLR. The 1, 3 and 5-year overall survival of patients in the NLR-normal group and NLR-elevated group were 57.3%, 44.1%, and 27.2% and 42.1%, 19.6%, and 9.5% respectively 0（2=194.2, P 〈0.001）. Similarly, the disease free survival also has a significant difference 0（2=39.3, P 〈0.001）. Multivariate Cox regression analysis showed that a high NLR was an independent factor affecting the survival rate of HCC after TACE （P=0.04）. Conclusion Preoperative NLR was an important prognostic factor to predict the prognosis of patients with intermediate HCC treated with TACE.展开更多
A lunar model with real texture can be obtained by mapping texture onto the lunar mesh,but the convergence in the polar regions of lunar model is a problem.In this paper,we build a 3D lunar model and solve this proble...A lunar model with real texture can be obtained by mapping texture onto the lunar mesh,but the convergence in the polar regions of lunar model is a problem.In this paper,we build a 3D lunar model and solve this problem by texture partitioning and transforming.The whole lunar map is divided into four images and the polar images are transformed to circular textures before mapped to the semi-regular(SR) lunar mesh which is obtained through denoising,triangulating,subdividing and resampling the laser altimetry(LAM) data.Hundreds of lunar labels are classed into three levels and added gradually to the lunar model considering the distance between the viewpoint and the moon center.Through some techniques such as mip-map and view-dependent,the lunar model with textures and labels can be interactively browsed on a personal computer(PC) in real time.展开更多
基金This work was supported by a grant from the National Natural Science Foundation of China （No. 81402022）.
文摘Background Accumulating evidence indicates that systemic inflammation response is associated with the prognosis of various cancers. The aim of this study was to investigate the neutrophil-lymphocyte ratio （NLR）, which is one of the systemic inflammation markers, in the prognosis of hepatocellular carcinoma （HCC） after treatment of transcatheter arterial chemoembolization （TACE）. Methods The clinical data of 178 HCC patients who received TACE were retrospectively analyzed. The optimal NLR cutoff was determined according to the receiver operating characteristic （ROC） analysis. All patients were divided into NLR-normal group and NLR-elevated group according to the cutoff, and the clinical features of these two groups were comparatively analyzed. Meanwhile, the overall survival and disease free survival （DFS） were analyzed using the Kaplan- Meier method. The risk factors of postoperative survival were investigated using univariate and multivariate Cox regression analyses. Results The optimal NLR cutoff was defined at 1.85 and 42 （23.6%） patients had an elevated NLR （NLR〉1.85）. The median survival time was 9.5 months （range 1-99 months）. The clinical data between the two groups were comparable, except for a-fetoprotein. Follow-up results showed that the median survival of patients with normal NLR was 17.5 months （range： 1-99 months） compared with 8 months （range： 8-68 months） of patients with elevated NLR. The 1, 3 and 5-year overall survival of patients in the NLR-normal group and NLR-elevated group were 57.3%, 44.1%, and 27.2% and 42.1%, 19.6%, and 9.5% respectively 0（2=194.2, P 〈0.001）. Similarly, the disease free survival also has a significant difference 0（2=39.3, P 〈0.001）. Multivariate Cox regression analysis showed that a high NLR was an independent factor affecting the survival rate of HCC after TACE （P=0.04）. Conclusion Preoperative NLR was an important prognostic factor to predict the prognosis of patients with intermediate HCC treated with TACE.
基金supported by the National High Technology Research and Development Program of China(Grant No.2013AA013702)
文摘A lunar model with real texture can be obtained by mapping texture onto the lunar mesh,but the convergence in the polar regions of lunar model is a problem.In this paper,we build a 3D lunar model and solve this problem by texture partitioning and transforming.The whole lunar map is divided into four images and the polar images are transformed to circular textures before mapped to the semi-regular(SR) lunar mesh which is obtained through denoising,triangulating,subdividing and resampling the laser altimetry(LAM) data.Hundreds of lunar labels are classed into three levels and added gradually to the lunar model considering the distance between the viewpoint and the moon center.Through some techniques such as mip-map and view-dependent,the lunar model with textures and labels can be interactively browsed on a personal computer(PC) in real time.
