Background Systemic inflammation and malnutrition have been proved to be correlated with poor survival in many cancers.Recently,the inflammation and nutrition based Glasgow prognostic score(GPS),based on serum levels ...Background Systemic inflammation and malnutrition have been proved to be correlated with poor survival in many cancers.Recently,the inflammation and nutrition based Glasgow prognostic score(GPS),based on serum levels of C-reactive protein(CRP)and albumin,has been used to predict survival in cancer,including gastric cancer.However,the significance of GPS in metastatic gastric cancer remains unknown.This study investigates the significance of the modified Glasgow prognostic score(mGPS)for the survival in patients with metastatic gastric cancer.Methods The mGPS(albumin<35 g/L=1 and CRP >10 mg/L=1)was calculated on the basis of the data for 344 patients with metastatic gastric cancer.Patients were allocated into mGPS of 0,1,or 2 groups according to the scores.The prognostic significance was analyzed by univariate analyses.Results Significant correlations were found between overall survival and CRP and mGPS.Sex,hemoglobin,white cell count,neutrophils and CEA were each significantly correlated with the mGPS.Univariate analysis showed that only mGPS was significantly associated with overall survival(OR,1.254;95%CI,1.069-1.472;P=0.006).Kaplan-Meier analysis demonstrated significant differences among patients with mGPS of 0,1 and 2(P=0.017),with the mortality rate higher for higher mGPS patients.Conclusion mGPS based on inflammation and nutrition,can predict survival in patients with metastatic gastric cancer.展开更多
基金Shanghai Pudong New Area Health Systems Discipline Construction Fund Project(No.PWZzb2017-05)Shanghai Pudong New Area Health Systems Academic Leader Fund Project(No.PWRD2014-04)National Natural Science Foundation(No.81672733).
文摘Background Systemic inflammation and malnutrition have been proved to be correlated with poor survival in many cancers.Recently,the inflammation and nutrition based Glasgow prognostic score(GPS),based on serum levels of C-reactive protein(CRP)and albumin,has been used to predict survival in cancer,including gastric cancer.However,the significance of GPS in metastatic gastric cancer remains unknown.This study investigates the significance of the modified Glasgow prognostic score(mGPS)for the survival in patients with metastatic gastric cancer.Methods The mGPS(albumin<35 g/L=1 and CRP >10 mg/L=1)was calculated on the basis of the data for 344 patients with metastatic gastric cancer.Patients were allocated into mGPS of 0,1,or 2 groups according to the scores.The prognostic significance was analyzed by univariate analyses.Results Significant correlations were found between overall survival and CRP and mGPS.Sex,hemoglobin,white cell count,neutrophils and CEA were each significantly correlated with the mGPS.Univariate analysis showed that only mGPS was significantly associated with overall survival(OR,1.254;95%CI,1.069-1.472;P=0.006).Kaplan-Meier analysis demonstrated significant differences among patients with mGPS of 0,1 and 2(P=0.017),with the mortality rate higher for higher mGPS patients.Conclusion mGPS based on inflammation and nutrition,can predict survival in patients with metastatic gastric cancer.
