The myostatin(MSTN)gene is considered a potential genetic marker to improve economically important traits in live-stock,since the discovery of its function using the MSTN knockout mice.The anti-myogenic function of th...The myostatin(MSTN)gene is considered a potential genetic marker to improve economically important traits in live-stock,since the discovery of its function using the MSTN knockout mice.The anti-myogenic function of the MSTN gene was further demonstrated in farm animal species with natural or induced mutations.In poultry species,myo-genesis in cell culture was regulated by modulation of the MSTN gene.Also,different expression levels of the MSTN gene in poultry models with different muscle mass have been reported,indicating the conserved myogenic function of the MSTN gene between mammalian and avian species.Recent advances of CRISPR/Cas9-mediated genome edit-ing techniques have led to development of genome-edited poultry species targeting the MSTN gene to clearly dem-onstrate its anti-myogenic function and further investigate other potential functions in poultry species.This review summarizes research conducted to understand the function of the MSTN gene in various poultry models from cells to whole organisms.Furthermore,the genome-edited poultry models targeting the MSTN gene are reviewed to inte-grate diverse effects of the MSTN gene on different traits of poultry species.展开更多
基金funded by the United States Department of Agricul-ture National Institute of Food and Agriculture Grant(Project No.2020-67030-31338)。
文摘The myostatin(MSTN)gene is considered a potential genetic marker to improve economically important traits in live-stock,since the discovery of its function using the MSTN knockout mice.The anti-myogenic function of the MSTN gene was further demonstrated in farm animal species with natural or induced mutations.In poultry species,myo-genesis in cell culture was regulated by modulation of the MSTN gene.Also,different expression levels of the MSTN gene in poultry models with different muscle mass have been reported,indicating the conserved myogenic function of the MSTN gene between mammalian and avian species.Recent advances of CRISPR/Cas9-mediated genome edit-ing techniques have led to development of genome-edited poultry species targeting the MSTN gene to clearly dem-onstrate its anti-myogenic function and further investigate other potential functions in poultry species.This review summarizes research conducted to understand the function of the MSTN gene in various poultry models from cells to whole organisms.Furthermore,the genome-edited poultry models targeting the MSTN gene are reviewed to inte-grate diverse effects of the MSTN gene on different traits of poultry species.
