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微流控芯片在年龄相关性黄斑变性中的研究进展
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作者 林碧倩 刘东成 秦波 《国际眼科杂志》 CAS 北大核心 2023年第11期1831-1834,共4页
年龄相关性黄斑变性(ARMD)是导致60岁以上人群视力严重受损与失明的重要原因。随着全球人口老龄化,该病的发病率也在逐年上升。然而,目前ARMD的发病机制和治疗方案仍需深入探究。作为一门新兴的前沿科学技术,微流控芯片技术可以构建模... 年龄相关性黄斑变性(ARMD)是导致60岁以上人群视力严重受损与失明的重要原因。随着全球人口老龄化,该病的发病率也在逐年上升。然而,目前ARMD的发病机制和治疗方案仍需深入探究。作为一门新兴的前沿科学技术,微流控芯片技术可以构建模拟人体组织和器官功能的综合微系统,具有样品消耗少、分析时间短等优势。近年来,大量研究证实微流控芯片能为ARMD的基础及临床研究带来全新的技术解决方案。本文对微流控芯片在ARMD机制研究、药物评价和临床转化等方面的应用进展予以讨论和回顾,为进一步研究ARMD的诊疗提供理论参考。 展开更多
关键词 微流控芯片 年龄相关性黄斑变性 机制研究 药物评价 临床转化
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Genomic Distribution of Quantitative Trait Loci for Yield and Yield-related Traits in Common Wheat 被引量:14
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作者 Li-Yi Zhang dong-cheng liu +4 位作者 Xiao-Li Guo Wen-Long Yang Jia-Zhu Sun Dao-Wen Wang Aimin Zhang 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2010年第11期996-1007,共12页
A major objective of quantitative trait locus (QTL) studies is to find genes/markers that can be used in breeding programs via marker assisted selection (MAS).We surveyed the QTLs for yield and yieldrelated traits... A major objective of quantitative trait locus (QTL) studies is to find genes/markers that can be used in breeding programs via marker assisted selection (MAS).We surveyed the QTLs for yield and yieldrelated traits and their genomic distributions in common wheat (Triticum aestivum L.) in the available published reports.We then carried out a meta-QTL (MQTL) analysis to identify the major and consistent QTLs for these traits.In total,55 MQTLs were identified,of which 12 significant MQTLs were located on wheat chromosomes 1A,1B,2A,2D,3B,4A,4B,4D and 5A.Our study showed that the genetic control of yield and its components in common wheat involved the important genes such as Rht and Vrn.Furthermore,several significant MQTLs were found in the chromosomal regions corresponding to several rice genomic locations containing important QTLs for yield related traits.Our results demonstrate that meta-QTL analysis is a powerful tool for confirming the major and stable QTLs and refining their chromosomal positions in common wheat,which may be useful for improving the MAS efficiency of yield related traits. 展开更多
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