BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic model.AIM To develop a new model,MRGC patients ...BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic model.AIM To develop a new model,MRGC patients who received fluoropyrimidines/platinum doublet chemotherapy between 2008 and 2015 were analyzed.METHODS A total of 1883 patients was divided into a training set(n=937)and an independent validation set(n=946).RESULTS Multivariate analysis showed that the following six factors were associated with poor overall survival(OS)in the training set:Eastern Cooperative Oncology Group performance score≥2 and bone metastasis(2 points each),peritoneal metastasis,high alkaline phosphatase level,low albumin level,and high neutrophil-lymphocyte ratio(1 point each).A prognostic model was developed by stratifying patients into good(0-1 point),moderate(2-3 points),and poor(≥4 points)risk groups.In the validation set,the median OS of the three risk groups was 15.8,10.1,and 5.7 mo,respectively,and those differences were significant(P<0.001).CONCLUSION We identified six factors readily measured in clinical practice that are predictive of poor prognosis in patients with MRGC.The new model is simpler than the old and more easily predicts OS.展开更多
Effect of different fire strengths on the smoke distribution in the subway station is investigated. Shin-Gum-Ho station （line #5） in Seoui is selected as a case study for variation of CO （carbon monoxide） distribu...Effect of different fire strengths on the smoke distribution in the subway station is investigated. Shin-Gum-Ho station （line #5） in Seoui is selected as a case study for variation of CO （carbon monoxide） distribution caused by the fire in the platform. The ventilation in the station is set to be an air supply mod in the lobby and an air exhaustion mod in the platform. One-side main tunnel ventilation （7,000 m3/min） is applied to operate in the tunnel. The fire is assumed to break out in the middle of train parked in the platform tunnel. Two kinds of fire strength are used. One is 10 MW and the other is 20 MW. Ventilation diffusers in the station are modeled as 317 square shapes ＆ four rectangular shapes in the lobby and platform. The total of 7.5 million grids is generated and whole domain is divided to 22 blocks for parallel computation. Large eddy simulation method is applied to solve the momentum equation. The behavior of CO is calculated according to different fire strengths and compared with each other.展开更多
文摘BACKGROUND New prognostic factors have been reported in patients with metastatic or recurrent gastric cancer(MRGC),necessitating modifications to the previous prognostic model.AIM To develop a new model,MRGC patients who received fluoropyrimidines/platinum doublet chemotherapy between 2008 and 2015 were analyzed.METHODS A total of 1883 patients was divided into a training set(n=937)and an independent validation set(n=946).RESULTS Multivariate analysis showed that the following six factors were associated with poor overall survival(OS)in the training set:Eastern Cooperative Oncology Group performance score≥2 and bone metastasis(2 points each),peritoneal metastasis,high alkaline phosphatase level,low albumin level,and high neutrophil-lymphocyte ratio(1 point each).A prognostic model was developed by stratifying patients into good(0-1 point),moderate(2-3 points),and poor(≥4 points)risk groups.In the validation set,the median OS of the three risk groups was 15.8,10.1,and 5.7 mo,respectively,and those differences were significant(P<0.001).CONCLUSION We identified six factors readily measured in clinical practice that are predictive of poor prognosis in patients with MRGC.The new model is simpler than the old and more easily predicts OS.
文摘Effect of different fire strengths on the smoke distribution in the subway station is investigated. Shin-Gum-Ho station （line #5） in Seoui is selected as a case study for variation of CO （carbon monoxide） distribution caused by the fire in the platform. The ventilation in the station is set to be an air supply mod in the lobby and an air exhaustion mod in the platform. One-side main tunnel ventilation （7,000 m3/min） is applied to operate in the tunnel. The fire is assumed to break out in the middle of train parked in the platform tunnel. Two kinds of fire strength are used. One is 10 MW and the other is 20 MW. Ventilation diffusers in the station are modeled as 317 square shapes ＆ four rectangular shapes in the lobby and platform. The total of 7.5 million grids is generated and whole domain is divided to 22 blocks for parallel computation. Large eddy simulation method is applied to solve the momentum equation. The behavior of CO is calculated according to different fire strengths and compared with each other.
