Serum RAAS molecules and their relationship with the systemic inflammatory response and target organ function in patients with severe acute pancreatitis

Objective:To explore the relationship of renin-angiotensin-aldosterone system (RAAS) activity with the systemic inflammatory response and target organ function in patients with severe acute pancreatitis.Methods: A total of 78 patients with severe acute pancreatitis who were treated in our hospital between August 2012 and March 2016 were selected as the observation group, and 50 healthy people who underwent physical examination in our hospital during the same period were selected as the normal control group. The differences in the contents of RAAS indexes, inflammation indexes as well as liver and kidney function indexes were compared between the two groups, and Pearson test was used to evaluate the correlation between RAAS activity and illness in patients with severe acute pancreatitis. Results: Serum RAAS indexes E, Ang-Ⅱ and ALD levels of observation group were higher than those of normal control group;serum inflammation indexes IL-6, IL-8, IL-10 and CRP levels were higher than those of normal control group;serum liver function indexes ALP,γ-GT and AST levels were higher than those of normal control group;serum kidney function indexes Scr, BUN and UA levels were higher than those of normal control group. The RAAS activity of patients with severe acute pancreatitis was directly correlated with serum levels of inflammation indexes as well as liver and kidney function indexes.Conclusion: The RAAS activity increases in patients with severe acute pancreatitis, and the specific increase extent is consistent with systemic inflammatory response as well as liver and kidney function damage.

Relationship of serum PCT content with the invasive growth of cancer cells and angiogenesis in patients with small cell lung cancer

Objective: To study the relationship of serum procalcitonin (PCT) content with the invasive growth of cancer cells and angiogenesis in patients with small cell lung cancer. Methods:Patients who were diagnosed with small cell lung cancer in Jiaoling People's Hospital in Meizhou between March 2015 and June 2017 were selected as the SCLC group of the research, and healthy volunteers who received physical examination during the same period were selected the control group. The serum was taken to determine the PCT content, and the tumor lesion tissue and adjacent lesion tissue for biopsy were taken to detect the expression of proliferation genes, invasion genes and angiogenesis genes. Results: Serum PCT content of SCLC group was significantly higher than that of control group;HOXA13, CyclinD1, MDM2, MMP9, Vimentin, N-cadherin, VEGF, VE-cadherin, EGFL8 and Nestin mRNA expression in tumor lesion tissue were significantly higher than those in adjacent lesion tissue whereas Nocth3, Rb, Bin1 and E-cadherin mRNA expression were significantly lower than those in adjacent lesion tissue;serum PCT content of patients with SCLC was positively correlated with HOXA13, CyclinD1, MDM2, MMP9, Vimentin, N-cadherin, VEGF, VE-cadherin, EGFL8 and Nestin mRNA expression in tumor lesion tissue, and negatively correlated with Nocth3, Rb, Bin1 and E-cadherin mRNA expression. Conclusion: The abnormal increase of serum PCT content in patients with small cell lung cancer is closely related to the infiltrative growth of cancer cells and angiogenesis in the lesion.