Mesenchymal stem cells(MSCs)secrete various cytokines with angiogenic and neuroprotective effects.This study aimed to assess the effects of human umbilical cord Wharton’s jelly-derived MSCs(hWJ-MSCs)on diabetes-relat...Mesenchymal stem cells(MSCs)secrete various cytokines with angiogenic and neuroprotective effects.This study aimed to assess the effects of human umbilical cord Wharton’s jelly-derived MSCs(hWJ-MSCs)on diabetes-related intracavernosal pressure(ICP)impairment in rats.hWJ-MSCs were isolated from human umbilical cord Wharton’s jelly and transplanted into the corpus cavernosum of streptozotocin(STZ)-induced diabetic rats by unilateral injection.The erectile function was evaluated at 4 weeks,as well as the expression levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),endothelial nitric oxide synthase(eNOS),and insulin-like growth factor 1(IGF1).STZ-induced diabetic rats showed impaired ICP,which was significantly improved by hWJ-MSC treatment.VEGF,eNOS,IGF1,and bFGF expression levels were higher in hWJ-MSC injection sites than those in control ones in STZ-induced diabetic rats.These results suggest that hWJ-MSC transplantation might improve diabetic erectile dysfunction through increased production of paracrine growth factors,highlighting a novel potential therapeutic option for erectile dysfunction.展开更多
基金This study was supported by the National Natural Science Foundation of China(No.81400683).
文摘Mesenchymal stem cells(MSCs)secrete various cytokines with angiogenic and neuroprotective effects.This study aimed to assess the effects of human umbilical cord Wharton’s jelly-derived MSCs(hWJ-MSCs)on diabetes-related intracavernosal pressure(ICP)impairment in rats.hWJ-MSCs were isolated from human umbilical cord Wharton’s jelly and transplanted into the corpus cavernosum of streptozotocin(STZ)-induced diabetic rats by unilateral injection.The erectile function was evaluated at 4 weeks,as well as the expression levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),endothelial nitric oxide synthase(eNOS),and insulin-like growth factor 1(IGF1).STZ-induced diabetic rats showed impaired ICP,which was significantly improved by hWJ-MSC treatment.VEGF,eNOS,IGF1,and bFGF expression levels were higher in hWJ-MSC injection sites than those in control ones in STZ-induced diabetic rats.These results suggest that hWJ-MSC transplantation might improve diabetic erectile dysfunction through increased production of paracrine growth factors,highlighting a novel potential therapeutic option for erectile dysfunction.
