Primary membranous nephropathy （PMN） is an antibody-mediated autoimmune glomeruLar disease. The incidence of PMN is 10/million populations/year and mostly adult patients present with nephrotic syndrome （NS）. Moreo...Primary membranous nephropathy （PMN） is an antibody-mediated autoimmune glomeruLar disease. The incidence of PMN is 10/million populations/year and mostly adult patients present with nephrotic syndrome （NS）. Moreover. the patients with persistent NS progressed to end-stage renal disease in 5-15 years.展开更多
The genome-wide characterization of long non-coding RNA(lncRNA)in insects demonstrates their importance in fundamental biological processes.Esentially,an in-depth understanding of the functional repertoire of lncRNA i...The genome-wide characterization of long non-coding RNA(lncRNA)in insects demonstrates their importance in fundamental biological processes.Esentially,an in-depth understanding of the functional repertoire of lncRNA in insects is pivotal to insect resources utilization and sustainable pest control.Using a custom bioinformatics pipeline,we identified 1861 lncRNAs encoded by 1852 loci in the Sogatella furcifera genome.We profiled lncRNA expression in different developmental stages and observed that the expression of lncRNAs is more highly temporally restricted compared to protein-coding genes.More up-re gulated Sogatella furcifera lncRNA expressed in the embryo,4th and 5th instars,suggesting that increased lncRNA levels may play a role in these developmental stages.We compared the relationship between the expression of Sogatella furcifera lncRNA and its nearest protein gene and found that lncRNAs were more correlated to their downstream coding neighbors on the opposite strand.Our genome-wide profiling of lncRNAs in Sogatella furcifera identifies exciting candidates for characterization of lncRNAs,and also provides information on lncRNA regulation during insect development.展开更多
To the Editor： Sepsis is one of the leading causes of death in Intensive Care Units. It is known as the syndrome of organ dysfunction caused by infection. Immune response has a critical role in sepsis. High concentra...To the Editor： Sepsis is one of the leading causes of death in Intensive Care Units. It is known as the syndrome of organ dysfunction caused by infection. Immune response has a critical role in sepsis. High concentrations of pro-inflammatory cytokines such as tumor necrosis factor alpha （TNF-α） and interleukin （IL）-6 have been suggested to be harmful and one of the major causes of organ injury.[1] Immune paralysis in sepsis causes a secondary infection.展开更多
文摘Primary membranous nephropathy （PMN） is an antibody-mediated autoimmune glomeruLar disease. The incidence of PMN is 10/million populations/year and mostly adult patients present with nephrotic syndrome （NS）. Moreover. the patients with persistent NS progressed to end-stage renal disease in 5-15 years.
基金This work was supported by the Strategic Priority Re-search Program of the Chinese Academy of Sciences(Grant XDB11040400)the National Natural Science Foundation of China(Grants 31571305,31871927).The funders played no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.
文摘The genome-wide characterization of long non-coding RNA(lncRNA)in insects demonstrates their importance in fundamental biological processes.Esentially,an in-depth understanding of the functional repertoire of lncRNA in insects is pivotal to insect resources utilization and sustainable pest control.Using a custom bioinformatics pipeline,we identified 1861 lncRNAs encoded by 1852 loci in the Sogatella furcifera genome.We profiled lncRNA expression in different developmental stages and observed that the expression of lncRNAs is more highly temporally restricted compared to protein-coding genes.More up-re gulated Sogatella furcifera lncRNA expressed in the embryo,4th and 5th instars,suggesting that increased lncRNA levels may play a role in these developmental stages.We compared the relationship between the expression of Sogatella furcifera lncRNA and its nearest protein gene and found that lncRNAs were more correlated to their downstream coding neighbors on the opposite strand.Our genome-wide profiling of lncRNAs in Sogatella furcifera identifies exciting candidates for characterization of lncRNAs,and also provides information on lncRNA regulation during insect development.
基金This study was supported by grants from the National Natural Science Foundation of China （No. 81772051） and Zhejiang Provincial Natural Science Foundation of China （No. LQ16CI20001）.
文摘To the Editor： Sepsis is one of the leading causes of death in Intensive Care Units. It is known as the syndrome of organ dysfunction caused by infection. Immune response has a critical role in sepsis. High concentrations of pro-inflammatory cytokines such as tumor necrosis factor alpha （TNF-α） and interleukin （IL）-6 have been suggested to be harmful and one of the major causes of organ injury.[1] Immune paralysis in sepsis causes a secondary infection.
