中医临床症状数据元提取探析（英文）

从数据共享的角度分析中医临床症状术语存在的问题,阐述了中医临床症状数据元标准建立的必要性。根据中医临床信息系统应用现状以及中医临床症状特点,分析了中医临床症状数据元提取的方法与原则,并提出了相对应的三层提取模型。

Lipid levels in serum and cancerous tissues of colorectal cancer patients

AIM:To investigate the correlations between lipid metabolism disorder and the occurrence and development of colorectal cancer by monitoring the alterations in lipid levels in cancerous tissue and serum in patients with colorectal cancer.METHODS:The levels of total and free cholesterol(TCH and FCH),triglycerides(TG),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),apolipoprotein A1(ApoA-1)and ApoB in serum of 206 patients with colorectal cancer,70patients with benign colorectal disease and 300 healthy participants,and in the cancerous tissue and paracancerous tissue of 152 patients with colorectal cancer were measured with an Olympus 600 auto-biochemical analyzer.The obtained data were statistically analyzed.RESULTS:Serum FCH level was significantly higher(1.9±0.4 mmol/L vs 1.3±0.3 mmol/L,1.9±0.4 mmol/L vs 1.2±0.4 mmol/L,P<0.05),whereas serum levels of TCH,LDL-C,ApoA-I and ApoB were significantly lower in patients with colorectal cancer than in patients with benign colorectal disease and healthy controls.The levels of FCH and TG in cancerous tissue were significantly lower(14.5±9.6μmol/g vs 19.3±13.9μmol/g,P<0.05;16.3±19.8μmol/g vs 44.1±38.1μmol/g,P<0.05),whereas HDL-C level was significantly higher(7.9±4.5μmol/g vs 5.7±3.9μmol/g,P<0.01)in cancerous tissue than in paracancerous tissue.The levels of TCH and TG in serum and the levels of TCH and HDL-C in cancerous tissue in patients with colorectal cancer were significantly correlated with TNM stage.The levels of TCH and LDL-C in serum were significantly lower,whereas HDL-C level in cancerous tissue was significantly higher in patients with lymph node metastasis than in patients without lymph node metastasis.The levels of TCH,FCH,TG,HDL-C and LDL-C in cancerous tissue were not significantly different from those in paracancerous tissue.The serum levels of FCH and TG were significantly higher,whereas serum HDL-C levels were significantly lower in patients with rectum cancer than in patients with colon cancer.CONCLUSION:The disordered and abnormally altered levels of lipids in cancerous tissue and serum of patients with colorectal cancer may be correlated with the occurrence and development of colorectal cancer.

Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer

AIM: To investigate the roles of serum insulin, insulinlike growth factor-1(IGF-1), and insulin-like growth factor binding proteins(IGFBPs) in the initiation and progression of colorectal cancer. METHODS: We determined serum insulin, IGF-1 and IGFBPs levels in 615 colorectal cancer patients and 650 control healthy donors by enzyme-linked immunosorbent assay(ELISA). In the meantime, their body mass index(BMI) and waist-to-hip ratio(WHR) were measured. RESULTS: Serum levels of insulin and IGF-1 as well as IGF-1/IGFBP-3 ratio in pre-operation patients were significantly elevated, but the level of IGFBP-3 was significantly decreased compared with normal controls and post-operation patients(P < 0.05 and P < 0.001,respectively). There is no significant difference(P > 0.05) in the levels of insulin, IGF-1, IGFBP-1, IGFBP-3 and IGF-1/IGFBP-3 between the patients with and without hepatic as well as distal abdominal metastases. WHR and BMI of colon cancer patients were positively and significantly correlated with the levels of insulin and IGF-1/IGFBP-3. In contrast, WHR and BMI were negatively correlated with IGFBP-3 level. CONCLUSION: The elevation of insulin, IGF-1 as well as IGF-1/IGFBP-3 ratio and the reduction of IGFBP-3 may be related to the initiation of colorectal cancer, but they are not related to the progression and outcome of the disease.

The Effect of Fascial Pedicled Island Flap of the First Metacarpal Radial Dorsal Artery Skin Branch Chain on the Repair of Thumb Tissue Defect

Objective To analyze the effect of fascial pedicled island flap of the first metacarpal radial dorsal artery skin branch chain on the repair of thumb tissue defect.Methods take the 100 patients with thumb tissue defects treated in our hospital from 2017.01 to 2019.01 as the research objects,and divide them into control group and observation group randomly,50 cases in each group.In the observation group,the fascial pedicled island flap of the first metacarpal radial dorsal artery skin branch chain is used for repair,and in the control group,the thumb tissue is repaired with abdominal flap.Compare the DASH scores and outcomes of two groups.Results After treatment,the DASH score in the observation group is significantly lower than that in the control group,which is statistically significant(P<0.05);The operation time and intraoperative blood loss of Observation Group is significantly lower than Control Group,which is statistically significant(P<0.05).Conclusion Repairing defected thumb with the fascial pedicled island flap of the first metacarpal radial dorsal artery skin branch chaint has the advantages of simple operation and easy mastery,and has significant curative effect on patients.It is an effective way to repair partial thumb defect,and worth popularizing.