Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 ...Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 and Bax proteins. Methods: A total of 45 SD rats were randomly divided into Fthe control group, model group and trigonelline intervention group. Rats in the control group were fed with the common diet, while rats in the model group and intervention group were fed with the high fat diet. 8 weeks later, the intervention group received the intragastric administration of trigonellin e(with the dosage of 40 mg/kg/d) for 8 weeks; while control group and model group received the intragastric administration of saline with the equal dosage. Blood was taken from the abdominal aorta of rats 8 weeks later, detecting the level of a series of indicators of ALT, AST, TG, TC, HDL-C and LDL-C in the serum. After the rats were sacrificed, detect the indicators of TG, TC, SOD and MDA in the liver tissue of rats, as well as the expression of Bcl-2 and Bax in the liver tissue. Results: Results of histopathologic examination showed that the damage degree of liver for rats in the trigonellineintervention group was smaller than the one in the model group, with significantly reduced hepatic steatosis and the partially visible hepatic lobule. The levels of ALT, AST, TC and LDL-C in the serum of rats in the trigonelline group were significantly reduced, while the change in the levels of TG and HDL-C was not significantly different. The levels of TG, TC and MDA in the liver tissues were significantly decreased, while the level of SOD significantly increased; the expression of Bcl-2 protein in the liver tissues of rats in the trigonelline intervention group was significantly increased, while the expression of Bax protein significantly decreased. Conclusions: The trigonelline contributes to the therapeutic effect of non-alcoholic fatty liver diseases. It can also increase the expression of Bcl-2 protein and decrease the expression of Bax protein in the liver tissues, which can protect the liver.展开更多
We experimentally and theoretically observe the expansion behaviors of a spherical Bose-Einstein condensate. A rubidium condensate is produced in an isotropic optical dipole trap with an asphericity of 0.037. We measu...We experimentally and theoretically observe the expansion behaviors of a spherical Bose-Einstein condensate. A rubidium condensate is produced in an isotropic optical dipole trap with an asphericity of 0.037. We measure the variation of the condensate size in the expansion process after switching off the trap. The free expansion of the condensate is isotropic,which is different from that of the condensate usually produced in the anisotropic trap. We derive an analytic solution of the expansion behavior based on the spherical symmetry, allowing a quantitative comparison with the experimental measurement. The interaction energy of the condensate is gradually converted into the kinetic energy during the expansion and after a long time the kinetic energy saturates at a constant value. We obtain the interaction energy of the condensate in the trap by probing the long-time expansion velocity, which agrees with the theoretical calculation. This work paves a way to explore novel quantum states of ultracold gases with the spherical symmetry.展开更多
The photodissociation of Br2 was investigated within the near-visible UV absorption band. Based on the potential curves for the ground and low-lying excited states, the optical cross-sections for the discrete transiti...The photodissociation of Br2 was investigated within the near-visible UV absorption band. Based on the potential curves for the ground and low-lying excited states, the optical cross-sections for the discrete transitions of C1^Пu,B^3Пou^+, A^3П1u←X^1∑g+ and their total energy absorption spectrum are derived, and the quantum yield of (Br+Br6*) channel are determined correspondingly. The one-dimensional Landau-Zener model is used to evaluate the behavior of curve crossing during photodissociation. The results indicate that the influence of nonadiabatic mechanism, which may be caused by the electronic-vibrational interplay between the 13 and C states, is negligibly small for the (Br+Br^*) channel. From the Landau-Zener modeling of the observed product recoil parameter β(Br+Br), the best-fit value of the coupling matrix elenment or coupling strength between the diabatic B and C state potentials is obtained.展开更多
We experimentally observe the dynamic evolution of atoms in the evaporative cooling, by in-situ imaging the plugged hole of ultracold atoms. Ultracold rubidium atoms confined in a magnetic trap are plugged using a blu...We experimentally observe the dynamic evolution of atoms in the evaporative cooling, by in-situ imaging the plugged hole of ultracold atoms. Ultracold rubidium atoms confined in a magnetic trap are plugged using a blue-detuned laser beam with a waist of 20 m at a wavelength of 767 nm. We probe the variation of the atomic temperature and width versus the radio frequency in the evaporative cooling. Both the behaviors are in good agreement with the calculation of the trapping potential dressed by the rf signal above the threshold temperature,while deviating from the calculation near the phase transition. To accurately obtain the atomic width, we use the plugged hole as the reference to optimize the optical imaging system by precisely minimizing the artificial structures due to the defocus effect.展开更多
基金supported by Natural Science Fund of Shandong Province(No.:ZR2009CL018)
文摘Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 and Bax proteins. Methods: A total of 45 SD rats were randomly divided into Fthe control group, model group and trigonelline intervention group. Rats in the control group were fed with the common diet, while rats in the model group and intervention group were fed with the high fat diet. 8 weeks later, the intervention group received the intragastric administration of trigonellin e(with the dosage of 40 mg/kg/d) for 8 weeks; while control group and model group received the intragastric administration of saline with the equal dosage. Blood was taken from the abdominal aorta of rats 8 weeks later, detecting the level of a series of indicators of ALT, AST, TG, TC, HDL-C and LDL-C in the serum. After the rats were sacrificed, detect the indicators of TG, TC, SOD and MDA in the liver tissue of rats, as well as the expression of Bcl-2 and Bax in the liver tissue. Results: Results of histopathologic examination showed that the damage degree of liver for rats in the trigonellineintervention group was smaller than the one in the model group, with significantly reduced hepatic steatosis and the partially visible hepatic lobule. The levels of ALT, AST, TC and LDL-C in the serum of rats in the trigonelline group were significantly reduced, while the change in the levels of TG and HDL-C was not significantly different. The levels of TG, TC and MDA in the liver tissues were significantly decreased, while the level of SOD significantly increased; the expression of Bcl-2 protein in the liver tissues of rats in the trigonelline intervention group was significantly increased, while the expression of Bax protein significantly decreased. Conclusions: The trigonelline contributes to the therapeutic effect of non-alcoholic fatty liver diseases. It can also increase the expression of Bcl-2 protein and decrease the expression of Bax protein in the liver tissues, which can protect the liver.
基金Project supported by the National Key Research and Development Program of China(Grant No.2016YFA0301503)the National Natural Science Foundation of China(Grant Nos.11674358,11434015,and 11474315)Chinese Academy of Sciences(Grant No.YJKYYQ20170025)
文摘We experimentally and theoretically observe the expansion behaviors of a spherical Bose-Einstein condensate. A rubidium condensate is produced in an isotropic optical dipole trap with an asphericity of 0.037. We measure the variation of the condensate size in the expansion process after switching off the trap. The free expansion of the condensate is isotropic,which is different from that of the condensate usually produced in the anisotropic trap. We derive an analytic solution of the expansion behavior based on the spherical symmetry, allowing a quantitative comparison with the experimental measurement. The interaction energy of the condensate is gradually converted into the kinetic energy during the expansion and after a long time the kinetic energy saturates at a constant value. We obtain the interaction energy of the condensate in the trap by probing the long-time expansion velocity, which agrees with the theoretical calculation. This work paves a way to explore novel quantum states of ultracold gases with the spherical symmetry.
基金ACKNOWLEDGMENT This work was supported by the National Natural Science Foundation of China (No.10534010 and No.20673140).
文摘The photodissociation of Br2 was investigated within the near-visible UV absorption band. Based on the potential curves for the ground and low-lying excited states, the optical cross-sections for the discrete transitions of C1^Пu,B^3Пou^+, A^3П1u←X^1∑g+ and their total energy absorption spectrum are derived, and the quantum yield of (Br+Br6*) channel are determined correspondingly. The one-dimensional Landau-Zener model is used to evaluate the behavior of curve crossing during photodissociation. The results indicate that the influence of nonadiabatic mechanism, which may be caused by the electronic-vibrational interplay between the 13 and C states, is negligibly small for the (Br+Br^*) channel. From the Landau-Zener modeling of the observed product recoil parameter β(Br+Br), the best-fit value of the coupling matrix elenment or coupling strength between the diabatic B and C state potentials is obtained.
基金Supported by the National Key Research and Development Program of China under Grant No 2016YFA0301503the National Natural Science Foundation of China under Grant Nos 11674358 and 11434015the Instrument Project of the Chinese Academy of Sciences under Grant No YJKYYQ20170025
文摘We experimentally observe the dynamic evolution of atoms in the evaporative cooling, by in-situ imaging the plugged hole of ultracold atoms. Ultracold rubidium atoms confined in a magnetic trap are plugged using a blue-detuned laser beam with a waist of 20 m at a wavelength of 767 nm. We probe the variation of the atomic temperature and width versus the radio frequency in the evaporative cooling. Both the behaviors are in good agreement with the calculation of the trapping potential dressed by the rf signal above the threshold temperature,while deviating from the calculation near the phase transition. To accurately obtain the atomic width, we use the plugged hole as the reference to optimize the optical imaging system by precisely minimizing the artificial structures due to the defocus effect.