AIM:To explore the related risk factors for diabetic retinopathy(DR)in type 2 diabetes with insulin therapy.METHODS:We studied the relationships among blood glucose,serum C-peptide,plasma insulin,beta-cell function an...AIM:To explore the related risk factors for diabetic retinopathy(DR)in type 2 diabetes with insulin therapy.METHODS:We studied the relationships among blood glucose,serum C-peptide,plasma insulin,beta-cell function and the development of DR.Beta-cell function was assessed by a modified homeostasis model assessment(modified HOMA)which was gained by using C-peptide to replace insulin in the homeostasis model assessment(HOMA)of beta-cell function.We also studied the relationships between modified HOMA index and serum C-peptide response to 100 g tasteless steamed bread to determine the accuracy of modified HOMA.RESULTS:Our study group consisted of 170 type 2diabetic inpatients with DR(age:58.35±13.87y,mean±SD)and 205 type 2 diabetic inpatients with no DR(NDR)(age:65.52±11.59y).DR patients had higher age,longer diabetic duration,higher hypertension grade,higher postprandial plasma glucose,higher fluctuation level of plasma glucose,lower body mass index(BMI),lower postprandial serum insulin and C-peptide,lower fluctuation level of serum insulin and C-peptide(P【0.05).In our logistic regression model,duration of diabetes,hypertension grade,fasting plasma insulin and glycosylated hemoglobin(HbA1C)were significantly associated with the presence of DR after adjustment for confounding factors(P【0.05).CONCLUSION:Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlationanalysis,logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors(such as age,sex,duration of diabetes,BMI,hypertension grade,HbA1C,plasma insulin).Duration of diabetes,hypertension grade,fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.展开更多
Dear Editor,Cornealendotheliitisisacommonandintriguing clinicalentitycharacterizedbycornealedema,keratic precipitates,and mild to moderate anterior chamber reaction,which occupies the important pathogenic factor of co...Dear Editor,Cornealendotheliitisisacommonandintriguing clinicalentitycharacterizedbycornealedema,keratic precipitates,and mild to moderate anterior chamber reaction,which occupies the important pathogenic factor of corneal blindness[1].Robin et al[2]first described a patient who suffered from intraocular inflammation and progressive corneal endotheliitis associated with herpes simplex infection.Since then,accumulating clinical evidence confirmed that its etiology was mainly attributed to the family of herpesviridae,including herpes simplex virus,varicella zoster virus,and cytomegalovirus,which initiated the direct cell damage and immune-and inflammatory-mediated lesion on endothelial cells[1,3].展开更多
We study the influence of the phase noises of far detuning single frequency lasers on the lifetime of Bose-Einstein condensation（BEC）of^（87）Rb in an optical dipole trap.As a comparison,we shine a continuous-wave s...We study the influence of the phase noises of far detuning single frequency lasers on the lifetime of Bose-Einstein condensation（BEC）of^（87）Rb in an optical dipole trap.As a comparison,we shine a continuous-wave singlefrequency Ti：sapphire laser,an external-cavity diode laser and a phase-locked diode laser on BEC.We measure the heating and lifetime of BEC in two different hyperfine states：｜F=2,m_F=2〉and｜F=1,m_F=1〉.Due to the narrow linewidth and small phase noise,the continuous-wave single-frequency Ti：sapphire laser has less influence on the lifetime of^（87）Rb BEC than the external-cavity diode laser.To reduce the phase noise of the external-cavity diode laser,we use an optical phase-locked loop for the external-cavity diode laser to be locked on a Ti：sapphire laser.The lifetime of BEC is increased when applfying the phase-Jocked diode laser in contrast with the external-cavity diode laser.展开更多
AIM:To investigate the risk of exudative retinal detachment(ERD)morbidity in patients with pregnancyinduced hypertension(PIH)by using the logistic regression combined with the receiver operating characteristic(ROC)cur...AIM:To investigate the risk of exudative retinal detachment(ERD)morbidity in patients with pregnancyinduced hypertension(PIH)by using the logistic regression combined with the receiver operating characteristic(ROC)curve.METHODS:A total of 46 patients with ERD and 142 patients with non-ERD were diagnosed as PIH from January 2017 to February 2020.A retrospective comparison of the clinical manifestations and laboratory tests were conducted.The risk of ERD morbidity with PIH was predicted by using logistic regression combined with an ROC curve model.RESULTS:There was no significant difference in age and body mass index between the two groups before pregnancy(P>0.05).However,significant differences were found in gestational weeks,duration of hypertension,maximum and minimum systolic and diastolic blood pressure(BP),and plasma total protein(PTP)concentration between the two groups(P<0.05).Binary logistic regression analysis showed that the maximum systolic BP(OR=1.050,95%CI:1.016-1.085)and PTP concentration(OR=0.764,95%CI:0.702-0.832)were independent prediction risks of ERD in PIH.The sensitivities of maximum systolic BP,PTP concentration and combined diagnosis were 0.717,0.870,and 0.870,respectively;the specificities were 0.617,0.837,and 0.908,respectively;the area under the curve(AUC)was 0.707(95%CI:0.622-0.792),0.917(95%CI:0.868-0.967),and 0.933(95%CI:0.890-0.975),respectively;the AUC of combined diagnosis was higher than that of single diagnosis(P<0.01).CONCLUSION:Logistic regression and ROC curve model combined with maximum systolic BP and PTP can improve the early identification of high-risk PIH patients in the hospital.展开更多
BACKGROUND Gastrointestinal(GI)vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment responses.Despite advancements in diagnostic and therapeutic techn...BACKGROUND Gastrointestinal(GI)vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment responses.Despite advancements in diagnostic and therapeutic techniques,optimal mana-gement strategies remain elusive,necessitating further research.AIM To assess research trends and clinical advancements in GI vascular bleeding disorders,highlighting key themes and therapeutic progress.METHODS A bibliometric analysis was conducted using the Web of Science Core Collection database,reviewing publications from 2000 to 2024 to identify trends,highfrequency keywords,and key contributions from leading research institutions.In addition,a case study highlighted the effective application of sirolimus in managing colonic angioectasia in a patient with recurrent GI bleeding who had not responded to previous treatments.RESULTS The analysis reviewed 470 scholarly articles from 203 countries,involving 2817 authors across 1502 institutions.The United States led in publication contributions,with strong collaborations with countries like China,England,and Germany.A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies,particularly highlighting the successful use of sirolimus in treating colonic angioectasia. High-frequency keywords such as “angiodysplasia”,“colon”, and “management” were identified, indicating key research themes. The study also noted a growinginterest in drug therapies, as evidenced by the increasing prominence of keywords like “thalidomide” since 2018.CONCLUSIONThis study links bibliometric analysis and clinical insights, highlighting the shift to pharmacological managementin GI vascular bleeding disorders to improve patient outcomes.展开更多
Decay constants of pseudoscalar mesons D,D_(s),η_(c) and vector mesons D^(*),D_(s)^(*),J/ψ are determined from the N_(f)=2+1 lattice QCD at a lattice spacing a~0.08 fm.For vector mesons,the decay constants defined b...Decay constants of pseudoscalar mesons D,D_(s),η_(c) and vector mesons D^(*),D_(s)^(*),J/ψ are determined from the N_(f)=2+1 lattice QCD at a lattice spacing a~0.08 fm.For vector mesons,the decay constants defined by tensor currents are given in the MS scheme at 2 GeV.The calculation is performed on domain wall fermion configurations generated by the RBC-UKQCD collaborations and the overlap fermion action is used for the valence quarks.Comparing the current results with our previous results at a coarser lattice spacing a ~0.11 fm provides a better understanding of the discretization error.We obtain f_(D_(s)^(*))^(T)(MS,2 GeV)/f_(D_(s)^(*))=0.909(18)with a better precision than our previous result.Combining our f_(D_(s)^(*))=277(11)MeV with the total width of D_(s)^(*) determined in a recent study gives a branching fraction 4.26(52)×10^(-5) for D_(s)^(*) leptonic decay.展开更多
The similar densities of dark matter and baryons in the universe imply that they may arise from the same ultraviolet model.B-Mesogenesis,which assumes dark matter is charged under the baryon number,attempts to simulta...The similar densities of dark matter and baryons in the universe imply that they may arise from the same ultraviolet model.B-Mesogenesis,which assumes dark matter is charged under the baryon number,attempts to simultaneously explain the origin of baryon asymmetry and dark matter in the universe.In particular,B-Mesogenesis may induce bottom-baryon decays into invisible or semi-invisible final states,which provide a distinctive signal for probing this scenario.In this work,we systematically study the invisible decays of bottom baryons into dark matter and the semi-invisible decays of bottom baryons into a meson or a photon together with a dark matter particle.In particular,the fully invisible decay can reveal the stable particles in B-Mesogenesis.Some QCD-based frameworks are used to calculate the hadronic matrix elements under the B-Mesogenesis model.We estimate the constraints on the Wilson coefficients or the product of some new physics couplings with the Wilson coefficients according to the semi-invisible and invisible decays of bottom baryons detectable at future colliders.展开更多
文摘AIM:To explore the related risk factors for diabetic retinopathy(DR)in type 2 diabetes with insulin therapy.METHODS:We studied the relationships among blood glucose,serum C-peptide,plasma insulin,beta-cell function and the development of DR.Beta-cell function was assessed by a modified homeostasis model assessment(modified HOMA)which was gained by using C-peptide to replace insulin in the homeostasis model assessment(HOMA)of beta-cell function.We also studied the relationships between modified HOMA index and serum C-peptide response to 100 g tasteless steamed bread to determine the accuracy of modified HOMA.RESULTS:Our study group consisted of 170 type 2diabetic inpatients with DR(age:58.35±13.87y,mean±SD)and 205 type 2 diabetic inpatients with no DR(NDR)(age:65.52±11.59y).DR patients had higher age,longer diabetic duration,higher hypertension grade,higher postprandial plasma glucose,higher fluctuation level of plasma glucose,lower body mass index(BMI),lower postprandial serum insulin and C-peptide,lower fluctuation level of serum insulin and C-peptide(P【0.05).In our logistic regression model,duration of diabetes,hypertension grade,fasting plasma insulin and glycosylated hemoglobin(HbA1C)were significantly associated with the presence of DR after adjustment for confounding factors(P【0.05).CONCLUSION:Our results suggested although modified HOMA showed significant correlation to the occurrence of DR on Spearman’s rank-correlationanalysis,logistic regression showed no significant association between these two variables after adjustment for relevant confounding factors(such as age,sex,duration of diabetes,BMI,hypertension grade,HbA1C,plasma insulin).Duration of diabetes,hypertension grade,fasting plasma insulin and HbA1C were independently associated with the development of DR in Chinese type 2 diabetics.
基金Supported by the National Natural Science Foundation of China (No.81870631)
文摘Dear Editor,Cornealendotheliitisisacommonandintriguing clinicalentitycharacterizedbycornealedema,keratic precipitates,and mild to moderate anterior chamber reaction,which occupies the important pathogenic factor of corneal blindness[1].Robin et al[2]first described a patient who suffered from intraocular inflammation and progressive corneal endotheliitis associated with herpes simplex infection.Since then,accumulating clinical evidence confirmed that its etiology was mainly attributed to the family of herpesviridae,including herpes simplex virus,varicella zoster virus,and cytomegalovirus,which initiated the direct cell damage and immune-and inflammatory-mediated lesion on endothelial cells[1,3].
基金Supported by the National Key Research and Development Program of China under Grant Nos 2016YFA0301600 and 2016YFA0301602the National Natural Science Foundation of China under Grant Nos 11234008,11474188 and 11704234the Fund for Shanxi'1331 Project'Key Subjects Construction
文摘We study the influence of the phase noises of far detuning single frequency lasers on the lifetime of Bose-Einstein condensation（BEC）of^（87）Rb in an optical dipole trap.As a comparison,we shine a continuous-wave singlefrequency Ti：sapphire laser,an external-cavity diode laser and a phase-locked diode laser on BEC.We measure the heating and lifetime of BEC in two different hyperfine states：｜F=2,m_F=2〉and｜F=1,m_F=1〉.Due to the narrow linewidth and small phase noise,the continuous-wave single-frequency Ti：sapphire laser has less influence on the lifetime of^（87）Rb BEC than the external-cavity diode laser.To reduce the phase noise of the external-cavity diode laser,we use an optical phase-locked loop for the external-cavity diode laser to be locked on a Ti：sapphire laser.The lifetime of BEC is increased when applfying the phase-Jocked diode laser in contrast with the external-cavity diode laser.
文摘AIM:To investigate the risk of exudative retinal detachment(ERD)morbidity in patients with pregnancyinduced hypertension(PIH)by using the logistic regression combined with the receiver operating characteristic(ROC)curve.METHODS:A total of 46 patients with ERD and 142 patients with non-ERD were diagnosed as PIH from January 2017 to February 2020.A retrospective comparison of the clinical manifestations and laboratory tests were conducted.The risk of ERD morbidity with PIH was predicted by using logistic regression combined with an ROC curve model.RESULTS:There was no significant difference in age and body mass index between the two groups before pregnancy(P>0.05).However,significant differences were found in gestational weeks,duration of hypertension,maximum and minimum systolic and diastolic blood pressure(BP),and plasma total protein(PTP)concentration between the two groups(P<0.05).Binary logistic regression analysis showed that the maximum systolic BP(OR=1.050,95%CI:1.016-1.085)and PTP concentration(OR=0.764,95%CI:0.702-0.832)were independent prediction risks of ERD in PIH.The sensitivities of maximum systolic BP,PTP concentration and combined diagnosis were 0.717,0.870,and 0.870,respectively;the specificities were 0.617,0.837,and 0.908,respectively;the area under the curve(AUC)was 0.707(95%CI:0.622-0.792),0.917(95%CI:0.868-0.967),and 0.933(95%CI:0.890-0.975),respectively;the AUC of combined diagnosis was higher than that of single diagnosis(P<0.01).CONCLUSION:Logistic regression and ROC curve model combined with maximum systolic BP and PTP can improve the early identification of high-risk PIH patients in the hospital.
基金Air Force Medical Center Youth Talent Program Project,No.22YXQN034Capital Health Development Research Special Project,No.2020-4-5123Beijing Haidian District Health and Wellness Development Scientific Research Cultivation Program,No.HP2021-03-80803.
文摘BACKGROUND Gastrointestinal(GI)vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment responses.Despite advancements in diagnostic and therapeutic techniques,optimal mana-gement strategies remain elusive,necessitating further research.AIM To assess research trends and clinical advancements in GI vascular bleeding disorders,highlighting key themes and therapeutic progress.METHODS A bibliometric analysis was conducted using the Web of Science Core Collection database,reviewing publications from 2000 to 2024 to identify trends,highfrequency keywords,and key contributions from leading research institutions.In addition,a case study highlighted the effective application of sirolimus in managing colonic angioectasia in a patient with recurrent GI bleeding who had not responded to previous treatments.RESULTS The analysis reviewed 470 scholarly articles from 203 countries,involving 2817 authors across 1502 institutions.The United States led in publication contributions,with strong collaborations with countries like China,England,and Germany.A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies,particularly highlighting the successful use of sirolimus in treating colonic angioectasia. High-frequency keywords such as “angiodysplasia”,“colon”, and “management” were identified, indicating key research themes. The study also noted a growinginterest in drug therapies, as evidenced by the increasing prominence of keywords like “thalidomide” since 2018.CONCLUSIONThis study links bibliometric analysis and clinical insights, highlighting the shift to pharmacological managementin GI vascular bleeding disorders to improve patient outcomes.
基金Supported in part by the National Key Research and Development Program of China(2020YFA0406400,2023YFA1606002)the National Natural Science Foundation of China(12075253,11935017,12192264,12293060,12293065,12293063,12070131001)+1 种基金CRC 110 by DFG and NNSFCsupported by the U.S.DOE Grant(DE-SC0013065)and DOE Grant(DEAC05-06OR23177),which is within the framework of the TMD Topical Collaboration。
文摘Decay constants of pseudoscalar mesons D,D_(s),η_(c) and vector mesons D^(*),D_(s)^(*),J/ψ are determined from the N_(f)=2+1 lattice QCD at a lattice spacing a~0.08 fm.For vector mesons,the decay constants defined by tensor currents are given in the MS scheme at 2 GeV.The calculation is performed on domain wall fermion configurations generated by the RBC-UKQCD collaborations and the overlap fermion action is used for the valence quarks.Comparing the current results with our previous results at a coarser lattice spacing a ~0.11 fm provides a better understanding of the discretization error.We obtain f_(D_(s)^(*))^(T)(MS,2 GeV)/f_(D_(s)^(*))=0.909(18)with a better precision than our previous result.Combining our f_(D_(s)^(*))=277(11)MeV with the total width of D_(s)^(*) determined in a recent study gives a branching fraction 4.26(52)×10^(-5) for D_(s)^(*) leptonic decay.
基金Supported by the National Key Research and Development Program of China(2020YFA0406400,2023YFA1606000)the National Natural ScienceFoundationof China(12335003,12275277)。
文摘The similar densities of dark matter and baryons in the universe imply that they may arise from the same ultraviolet model.B-Mesogenesis,which assumes dark matter is charged under the baryon number,attempts to simultaneously explain the origin of baryon asymmetry and dark matter in the universe.In particular,B-Mesogenesis may induce bottom-baryon decays into invisible or semi-invisible final states,which provide a distinctive signal for probing this scenario.In this work,we systematically study the invisible decays of bottom baryons into dark matter and the semi-invisible decays of bottom baryons into a meson or a photon together with a dark matter particle.In particular,the fully invisible decay can reveal the stable particles in B-Mesogenesis.Some QCD-based frameworks are used to calculate the hadronic matrix elements under the B-Mesogenesis model.We estimate the constraints on the Wilson coefficients or the product of some new physics couplings with the Wilson coefficients according to the semi-invisible and invisible decays of bottom baryons detectable at future colliders.
