Oil-gas-water three-phase flow in the pipe is commonly encountered in the petroleum and nature gas industry. Its flow patterns are complex and always changeable, so it’s difficult to be measured and is becoming one o...Oil-gas-water three-phase flow in the pipe is commonly encountered in the petroleum and nature gas industry. Its flow patterns are complex and always changeable, so it’s difficult to be measured and is becoming one of the most important subjects. Moreover, most of the oil fields in China are in such a high water fraction period that measures must be taken to meet the needs of the actual production. A conductance sensor which is widely used in the measurements of oil-water two-phase flow is used to measure the flow rate of the three-phase flow based on the research of the characteristics and the correlation theory, and a new technical solution which is suitable for measuring the oil-gas-water three-phase flow is established. A series of tests demonstrate that it’s feasible to use the conductance sensor in the measurements of oil- gas-water three-phase flow.展开更多
A predictive pharmacophore model has been generated from a series of diverse fatty acid amide hydrolase(FAAH)inhibitors and the optimal pharmacophore model applied in virtual screening.The pharmacophore model was base...A predictive pharmacophore model has been generated from a series of diverse fatty acid amide hydrolase(FAAH)inhibitors and the optimal pharmacophore model applied in virtual screening.The pharmacophore model was based on a training set of 21 compounds carefully selected from the published literatures.The optimal model Hypo-1 included four features(two hydrogen-bond acceptor units,one aromatic hydrophobic unit and one aromatic ring unit)and two excluded volumes.Cross-validation of the model confirmed that Hypo-1 was not generated by chance correlation.A large test set of 55 compounds showed that Hypo-1 performed well in classifying highly active and less active FAAH inhibitors.Superimposition analysis of the FAAH X-ray crystal structure and the pharmacophore Hypo-1 further validated the adequacy of the model.Virtual screening generated a total of 976 hits from the Zinc Natural Products database,a hit rate of 1.04%and enrichment of 83.89.The acceptable hit rate further supports the use of Hypo-1 as a 3D query tool for virtual screening.展开更多
文摘Oil-gas-water three-phase flow in the pipe is commonly encountered in the petroleum and nature gas industry. Its flow patterns are complex and always changeable, so it’s difficult to be measured and is becoming one of the most important subjects. Moreover, most of the oil fields in China are in such a high water fraction period that measures must be taken to meet the needs of the actual production. A conductance sensor which is widely used in the measurements of oil-water two-phase flow is used to measure the flow rate of the three-phase flow based on the research of the characteristics and the correlation theory, and a new technical solution which is suitable for measuring the oil-gas-water three-phase flow is established. A series of tests demonstrate that it’s feasible to use the conductance sensor in the measurements of oil- gas-water three-phase flow.
基金supported by the National Science Foundation of China(Grant No.40976050)。
文摘A predictive pharmacophore model has been generated from a series of diverse fatty acid amide hydrolase(FAAH)inhibitors and the optimal pharmacophore model applied in virtual screening.The pharmacophore model was based on a training set of 21 compounds carefully selected from the published literatures.The optimal model Hypo-1 included four features(two hydrogen-bond acceptor units,one aromatic hydrophobic unit and one aromatic ring unit)and two excluded volumes.Cross-validation of the model confirmed that Hypo-1 was not generated by chance correlation.A large test set of 55 compounds showed that Hypo-1 performed well in classifying highly active and less active FAAH inhibitors.Superimposition analysis of the FAAH X-ray crystal structure and the pharmacophore Hypo-1 further validated the adequacy of the model.Virtual screening generated a total of 976 hits from the Zinc Natural Products database,a hit rate of 1.04%and enrichment of 83.89.The acceptable hit rate further supports the use of Hypo-1 as a 3D query tool for virtual screening.
