Association Between Lipid Profiles and Left Ventricular Hypertrophy:New Evidence from a Retrospective Study

Objective To explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population.Methods We conducted a retrospective observational study to investigate the relationship between lipid markers[including triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein(HDL)cholesterol,non-HDL-cholesterol,apolipoprotein A-I,apolipoprotein B,lipoprotein[a],and composite lipid profiles]and left ventricular hypertrophy.A total of 309,400 participants of two populations(one from Beijing and another from nationwide)who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study.7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy.Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the mterventricular septum or left ventricle posterior wall>11 mm.The Logistic regression model was used in the cross-sectional study.Cox model and Cox model with restricted cubic splines were used in the longitudinal cohort.Results In the cross-sectional study for participants in the highest tertile of each lipid marker compared to the respective lowest,triglycerides[odds ratio(OR):1.2S0,95%CI:1.060 to 1.474],HDL-cholesterol(OR:0.780,95%CI:0.662 to 0.918),and lipoprotein(a)(OR:1.311,95%C7:1.115 to 1.541)had an association with left ventricular hypertrophy.In the longitudinal cohort,for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest,triglycerides[hazard ratio(HR):3.277,95%C/:1.720 to 6.244],HDL-cholesterol(HR:0.516,95%C7:0.283 to 0.940),non-HDL-cholesterol(HR:2.309,95%C/:1.296 to 4.112),apolipoprotein B(HR:2.244,95%CI:1.251 to 4.032)showed an association with new-onset left ventricular hypertrophy.In the Cox model with forward stepwise selection,triglycerides were the only lipid markers entered into the final model.Conclusion Lipids levels,especially triglycerides,are associated with left ventricular hypertrophy.Controlling triglycerides level potentiate to be a strategy in harnessing cardiac remodeling but deserve to be furdier investigated.

Comparison of the anxiety level between the medical staff and the public during the early phase of the coronavirus disease 2019 pandemic

Background:A sudden outbreak of the coronavirus disease 2019(COVID-19)started in December 2019 in Wuhan,China.Up-to-date,there have been limited studies examining the anxiety status of Chinese individuals in the early phase of the pandemic period(January 30,2020–February 15,2020).This survey aimed to compare the level of anxiety of the medical staff with that of the public and to provide a theoretical basis for developing an effective psychological intervention.Method:Questionnaires were sent on the Internet(http://www.wjx.cn)during this period.The anxiety levels of Chinese people were investigated using the Self-Rating Anxiety Scale(SAS),and the demographic data were collected simultaneously.Results:A total of 1110 participants were enrolled in this study,with an effective response rate of 100%.A total of 482 respondents were medical staff(43.4%),while 628 were members of the general public(56.6%).The medical staff itself had a higher SAS score than the general public(48.36±13.40 vs.45.74±11.79,P<0.01),while the medical staff in Wuhan were more anxious than the public in Wuhan with a higher SAS score(54.17±14.08 vs.48.53±11.92,P<0.01).Conclusion:The COVID-19 pandemic has had a significant impact on the anxiety levels of the medical staff and the public,with the medical personnel showing a higher anxiety level than the public,especially female medical staff in Wuhan.Therefore,urgent intervention programs to reduce anxiety should be implemented.