In this study,MnCo2O4 nanosheets were proposed to be utilized as an electrode material for supercapacitors.A two-step hydrothermal method with post-annealing treatment was employed in preparation of the nanostructures...In this study,MnCo2O4 nanosheets were proposed to be utilized as an electrode material for supercapacitors.A two-step hydrothermal method with post-annealing treatment was employed in preparation of the nanostructures.MnCo2O4 electrode delivered a high specific capacitance of 2000 F g^-1 at 0.5 A g^-1,remarkable high-rate capability of 1150 F g^-1 at 20 A g^-1,and an excellent cycling stability of 92.3%at 5 A g^-1 after 5000 cycles.It is found that a three-electrode supercapacitor based on MnCo2O4 exhibits a promising electrochemical performance,better than the other similar materials,benefited from the synergistic effects of MnCo2O4 nanosheets.In fact,the self-assembly of nanosheets structure with high specific surface area and mesoporous structure can potentially enhance the electrochemical performance of supercapacitors.展开更多
The development and synthesis of cathode electrocatalysts with high activity and durable stability for metal-air batteries is an important challenge in the area of electrocatalysis.Herein,we introduce a novel in-situ ...The development and synthesis of cathode electrocatalysts with high activity and durable stability for metal-air batteries is an important challenge in the area of electrocatalysis.Herein,we introduce a novel in-situ nitriding and phosphating strategy for producing W_(3)N_(4)and WP from phosphotungstic acid(HPW)-polyaniline-phytic acid-Fe3+organic-inorganic hybrid material.The final material has a three-dimensional porous framework with W_(3)N_(4)-WP heterostructures embedded in the carbon matrix(W_(3)N_(4)-WP@NPC).As-made materials exhibit exceptional electrocatalytic performance for the oxygen reduction reaction(ORR),with a diffusion-limiting current density of 6.9 mA·cm^(−2)and a half-wave potential of 0.82 V.As a Zn-air primary cathode,the W_(3)N_(4)-WP@NPC assembled battery can provide a relatively high peak power density(194.2 mW·cm^(−2)).As a Zn-air secondary air-cathode,it has great cycling stability over 500 h.This work provides a simple and efficient method for rationally designing high-performance air cathodes from copolymer-anchored polyoxometalates.展开更多
Triple-negative breast cancer(TNBC)is a subtype of breast cancer with high mortality,and the efficacy of monotherapy for TNBC is still disappointing.Here,we developed a novel combination therapy for TNBC based on a mu...Triple-negative breast cancer(TNBC)is a subtype of breast cancer with high mortality,and the efficacy of monotherapy for TNBC is still disappointing.Here,we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon sphere.This intelligent material contains a superadsorbed silicon dioxide sphere,sufficient loading space,a nanoscale hole on its surface,a robust shell,and an outer bilayer,and it could load both programmed cell death protein 1/programmed cell death ligand 1(PD-1/PD-L1)small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents,protect these small molecules during the systemic circulation,and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation,thereby realizing dual attack of photodynamic therapy and immunotherapy on tumors.Importantly,we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses,further enhancing the therapeutic effect.Thus,a novel combination therapy“PD-1/PD-L1 immune checkpoint blockade+photodynamic therapy+fasting-mimicking diet”was developed with the aid of our materials,which eventually achieved a marked therapeutic effect in 4T1-tumor-bearing mice.The concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future.展开更多
The rational design and preparation of promising cathode electrocatalysts with excellent activity and strong stability for metal-air batteries is a huge challenge.In this work,we innovate an approach of combining solv...The rational design and preparation of promising cathode electrocatalysts with excellent activity and strong stability for metal-air batteries is a huge challenge.In this work,we innovate an approach of combining solvothermal with high-temperature pyrolysis utilizing zeolitic imidazolate framework(ZIF)-8 and ZIF-67 as the template to synthesize a novel hybrid material of hierarchical porous yolk-shell Co-N-C polyhedron nanocatalysts engaged in graphene nanopocket(yolk-shell Co-N-C@GNP).The obtained catalyst exhibits prominent bifunctional electrocatalytic performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)in the alkaline condition,in which the half-wave potential is 0.86 V for ORR,and the over-potential for OER is 0.42 V at 10 mA·cm^(-2).The rechargeable aqueous Zn-air battery fabricated with yolk-shell Co-N-C@GNP cathode deliveries an open circuit voltage(OCV)of 1.60 V,a peak power density of 236.2 mW·cm^(-2),and excellent cycling stability over 94 h at 5 mA·cm^(-2).The quasi-solid-state Zn-air battery(ZAB)using yolk-shell Co-N-C@GNP displays a high OCV of 1.40 V and a small voltage gap of 0.88 V in continuous cycling tests at 2 mA·cm^(-2).This work provides a valuable thought to focus attention on the design of high-efficient bifunctional catalysts with hierarchical porous yolk-shell framework and high-density metal active sites for metal-air battery technologies.展开更多
基金supported by the National Natural Science Foundation of China (51572194)the National Key Research and Development Program of China (2018YFB0105900)
文摘In this study,MnCo2O4 nanosheets were proposed to be utilized as an electrode material for supercapacitors.A two-step hydrothermal method with post-annealing treatment was employed in preparation of the nanostructures.MnCo2O4 electrode delivered a high specific capacitance of 2000 F g^-1 at 0.5 A g^-1,remarkable high-rate capability of 1150 F g^-1 at 20 A g^-1,and an excellent cycling stability of 92.3%at 5 A g^-1 after 5000 cycles.It is found that a three-electrode supercapacitor based on MnCo2O4 exhibits a promising electrochemical performance,better than the other similar materials,benefited from the synergistic effects of MnCo2O4 nanosheets.In fact,the self-assembly of nanosheets structure with high specific surface area and mesoporous structure can potentially enhance the electrochemical performance of supercapacitors.
基金the Hubei Provincial Natural Science Foundation and Huangshi of China(No.2022CFD039)the National Natural Science Foundation of China(No.22008058)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20220912)the China Postdoctoral Science Foundation(No.2022M711607).
文摘The development and synthesis of cathode electrocatalysts with high activity and durable stability for metal-air batteries is an important challenge in the area of electrocatalysis.Herein,we introduce a novel in-situ nitriding and phosphating strategy for producing W_(3)N_(4)and WP from phosphotungstic acid(HPW)-polyaniline-phytic acid-Fe3+organic-inorganic hybrid material.The final material has a three-dimensional porous framework with W_(3)N_(4)-WP heterostructures embedded in the carbon matrix(W_(3)N_(4)-WP@NPC).As-made materials exhibit exceptional electrocatalytic performance for the oxygen reduction reaction(ORR),with a diffusion-limiting current density of 6.9 mA·cm^(−2)and a half-wave potential of 0.82 V.As a Zn-air primary cathode,the W_(3)N_(4)-WP@NPC assembled battery can provide a relatively high peak power density(194.2 mW·cm^(−2)).As a Zn-air secondary air-cathode,it has great cycling stability over 500 h.This work provides a simple and efficient method for rationally designing high-performance air cathodes from copolymer-anchored polyoxometalates.
基金This work was financially supported by the National Natural Science Foundation of China(grant nos.31971307 and 32000950)Beijing Institute of Technology Research Fund Program for Young Scholars(XSQD-202213001 and grant no.3320012222215)+6 种基金the State Key Laboratory of Electrical Insulation and Power Equipment,Xi’an Jiaotong University(EIPE22208)the National Postdoctoral Program for Innovative Talents(grant no.BX20200222)the China Postdoctoral Science Foundation(grant no.2020M682878)National Natural Science Foundation of China(grant no.52202284)Zhejiang Natural Science Foundation(grant no.LQ23E020002)Wenzhou Natural Science Foundation(grant no.G20220019)cooperation between industry and education project of Ministry of Education(grant no.220601318235513).
文摘Triple-negative breast cancer(TNBC)is a subtype of breast cancer with high mortality,and the efficacy of monotherapy for TNBC is still disappointing.Here,we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon sphere.This intelligent material contains a superadsorbed silicon dioxide sphere,sufficient loading space,a nanoscale hole on its surface,a robust shell,and an outer bilayer,and it could load both programmed cell death protein 1/programmed cell death ligand 1(PD-1/PD-L1)small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents,protect these small molecules during the systemic circulation,and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation,thereby realizing dual attack of photodynamic therapy and immunotherapy on tumors.Importantly,we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses,further enhancing the therapeutic effect.Thus,a novel combination therapy“PD-1/PD-L1 immune checkpoint blockade+photodynamic therapy+fasting-mimicking diet”was developed with the aid of our materials,which eventually achieved a marked therapeutic effect in 4T1-tumor-bearing mice.The concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future.
基金This study was supported by the National Natural Science Foundation of China(Nos.22008058 and 52074119)the Joint Funds of National Natural Science Foundation of China(No.U20A20280)+3 种基金the program for Innovative Teams of Outstanding Young and Middle-aged Researchers in the Higher Education Institutions of Hubei Province(No.T2021010)the Joint supported by Hubei Provincial Natural Science Foundation and Huangshi of China(No.2022CFD039)the Postgraduate Innovative Research Project of Hubei Normal University(Nos.20220512 and 20220552)College Students innovation and entrepreneurship training program of Hubei Province(No.S202210513055).
文摘The rational design and preparation of promising cathode electrocatalysts with excellent activity and strong stability for metal-air batteries is a huge challenge.In this work,we innovate an approach of combining solvothermal with high-temperature pyrolysis utilizing zeolitic imidazolate framework(ZIF)-8 and ZIF-67 as the template to synthesize a novel hybrid material of hierarchical porous yolk-shell Co-N-C polyhedron nanocatalysts engaged in graphene nanopocket(yolk-shell Co-N-C@GNP).The obtained catalyst exhibits prominent bifunctional electrocatalytic performance for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)in the alkaline condition,in which the half-wave potential is 0.86 V for ORR,and the over-potential for OER is 0.42 V at 10 mA·cm^(-2).The rechargeable aqueous Zn-air battery fabricated with yolk-shell Co-N-C@GNP cathode deliveries an open circuit voltage(OCV)of 1.60 V,a peak power density of 236.2 mW·cm^(-2),and excellent cycling stability over 94 h at 5 mA·cm^(-2).The quasi-solid-state Zn-air battery(ZAB)using yolk-shell Co-N-C@GNP displays a high OCV of 1.40 V and a small voltage gap of 0.88 V in continuous cycling tests at 2 mA·cm^(-2).This work provides a valuable thought to focus attention on the design of high-efficient bifunctional catalysts with hierarchical porous yolk-shell framework and high-density metal active sites for metal-air battery technologies.