Development, Application and Prospect of Dissolving Microneedles

In recent years, as a new transdermal drug delivery method, microneedle transdermal drug delivery technology accelerates the absorption of drugs through micron pores, which has been widely used in the field of medicine and cosmetics. Dissolving microneedles have the characteristics of good biocompatibility and fast dissolution speed, which attract more and more researchers’ attention and research. In this paper, the concept, properties and preparation methods of dissolving microneedles as well as the research status of dissolving microneedles in the field of medicine and cosmetics in recent years were summarized and prospected, so as to enable researchers to have a clearer and comprehensive understanding of dissolving microneedles and prospect the application and development prospects of dissolving microneedles in the industry.

3-喹啉/3-吡啶混合取代阳离子型卟啉化合物的制备和生物活性研究(英文)

目的 :寻找具有阳离子型卟啉结构的强效端粒酶抑制剂。方法 :采用Adler Longo卟啉合成法通过芳香醛和吡咯的缩合反应制得各种组合的 3 喹啉 /3 吡啶基卟啉碱基 ,再经甲基化、离子交换得阳离子型卟啉化合物。测试所合成化合物的端粒酶抑制活性和c Myc抑制活性。结果 :非细胞试验显示所合成的化合物具有强的端粒酶抑制活性 ;而化合物 4显示最强的c Myc抑制活性。