Study on Formation Mechanism of Dumping Piles on Dumping Area Stability

Dumping areas represent a stable hazard. To clarify the formation mechanism of dumping piles on dumping area stability, an investigation in open pit mine was performed. Moreover, experiments with gravel were conducted based on the research site conditions. The geological conditions, dumping operation, and waste particle size distribution were investigated in the Heidaigou open pit mine. Particle size distribution, dumping height, dumping volume, and floor inclination were varied to examine their effects on a single pile formation. The design of blasting can be modified to make the particle size of waste smaller. The volume of the bucket does not have a pronounced effect on dumping pile repose angle, capacity of dumping pile, and dumping area stability. The smaller the floor inclination, the better it is. Two measures are proposed to increase the kinetic force of friction between waste material and floor surface. The interval distance, dumping volume and dumping height were also varied to examine the interaction between the formations of multiple piles. The dumping width should be decided through optimization efficiency of bulldozer and dumping device in bucket wheel excavator-belt-stacker dumping operation and dragline dumping operation. Moreover, the volume of the bucket does not have a pronounced interaction effect. In the dumping operation, the work amount of bulldozer decreases as dumping pile increases. The design of the dumping operation must consider the total efficiency of ground leveling operation and forming dumping the area.

Evaluation of speech function on repairing defects of maxilla and palate with temporalis muscle flap

Objective： To evaluate the speech function on repairing defects of maxilla and palate with temporalis muscle flap after benign or malignant turmor resection. Methods： The lateral cephalogram and speech intelligibility were detected in 19 cases with the operations of repairing defects of maxilla and palate by temporalis muscle flap, and their recovery of the speech function were analyzed. Results： Among the 19 patients, there were 15 cases （78.00%） with complete velopharynx, 3 cases （15.80%） with mafiginal velopharynx, and 1 case （5.26%） with insufficient velopharynx. The average speech intelligibility was 94.3%, close to the normal speech intelligibility. Conclusion： The operation of repairing defects of maxilla and palate with temporalis muscle flap can reconstruct the phonatory structure, preserve the palate function and restore the speech function after operation.

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Epstein–Barr virus(EBV)-associated lymphoproliferative diseases(EBV-LPDs)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been reported.Two patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapses after multiple lines of treatment.After receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete remission.However,with a median time of 38.5 months after CAR-T cell therapy,B-cell-derived EBV-LPDs were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting agents.Collectively,our report suggests that EBV-LPDs may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EBV-positive disorders,and they can be resolved by immune normalization strategy or B-cell depleting therapy.

Micro-sized hydrothermal carbon supporting metal oxide nanoparticles as efficient catalyst for mono-dehydration of sugar alcohol

Most known catalytic dehydration of sugar alcohols such as D-sorbitol and D-mannitol can only produce di-dehydrated forms as major product,but monodehydrated products are also useful chemicals.Moreover,both di-and mono-dehydration demand a high temperature(150℃ or higher),which deserves further attentions.To improve the mono-dehydration efficiency,a series of metal-containing hydrothermal carbonaceous materials(HTC)are prepared as catalyst in this work.Characterization reveals that the composition of preparative solution has a key influence on the morphology of HTC.In transformation of D-sorbitol,all HTC catalysts show low conversions in water regardless of temperature,but much better outputs are obtained in ethanol,especially at a higher temperature.When D-mannitol is selected as substrate,moderate to high conversions are obtained in both water and ethanol.On the other hand,high mono-dehydration selectivity is obtained for both sugar alcohols by using all catalysts.The origin of mono-dehydration selectivity and role of carbon component in catalysis are discussed in association with calculations.This study provides an efficient,mild,eco-friendly,and cost-effective system for mono-dehydration of sugar alcohols,which means a lot to development in new detergents or other fine chemicals.