Effects of the Rainfall-Triggered Lisse Effect on the Stability of Loess Slopes

This paper coupled a water-air two-phase hydrodynamic(WATPH)model with the Iverson’s method to analyze the influence of the Lisse effect on the fast groundwater pressure(P_(w))response and the slope stability.Furthermore,the sensitivities of the driving force and loess soil parameters were investigated.Results showed that the WATPH model simulated the height and rise of the depth to the water table reasonably well.The depth to water table before rainfall(H0)had a significant impact on the Lisse effect and the slope stability.When the H_(0) was less than approximately 1 m,the rainfall triggered a significant Lisse effect and decreased the slope factor of safety(F_(s)).When the rainfall intensity(R_(i))was higher than the saturated hydraulic conductivity(K_(s)),the Lisse effect and the F_(s) slightly changed with the increase of the R_(i),and the slope tended to be unstable with continuous rainfall.With increasing K_(s),the Lisse effect noticeably increased,and the minimum F_(s) quickly decreases.The analysis of the normalized sensitivity coefficient revealed that H_(0) had a dramatic impact on the Lisse effect and loess slope stability.The different R_(i) and K_(s) values had prominent influences on the Lisse effect and slight impacts on F_(s).

Epinephrine promotes tumor progression and M2 polarization of tumor-associated macrophages by regulating the TRIM2-NF-kB pathway in colorectal cancer cells

Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor progression.In the tumor microenvironment,tumor-associated macrophages(TAMs)receive different stimuli and can be polarized into classically activated M1 macrophages and alternatively activated M2 macrophages.Many studies have indicated that the polarization of TAMs is closely related to tumor progression.